Definition: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Other names ddC (Antiviral); Dideoxycytidine; 2',3'-Dideoxycytidine; NSC 606170; 2',3' Dideoxycytidine; Roche Brand of Zalcitabine; NSC-606170; HIVID Roche; Hoffman-La Roche Brand of Zalcitabine; NSC606170; Hivid
2',3'-dideoxy-5-fluoro-3'-thiacytidine [ 1-(2-(hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine,2',3',5-FTC,2',3'-dideoxy-5-fluoro-3'-thiacytidine, (2S-cis)-isomer,5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine,524W91,BW 524W91,BW-524W91,BW524W91,Racivir ] RN given refers to (2R-cis)-isomer; RN for cpd without isomeric designation not available 2/93