Definition: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
lurtotecan [ GG-211,7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin,GG211,GI 147211,GI-147211,GI147211,Gl 147211C,Gl-147211C,Gl147211C,NX 211,NX-211,NX211 cpd,OSI 211,OSI-211,OSI211 ] NX-211 is the low-clearance liposomal formulation; structure in first source