Definition: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
pegfilgrastim [ Amgen brand of pegfilgrastim,Neulasta,PEG SD-01,PEG-rmetHuG-CSF,SD-01, polyethylene glycol-conjugated filgrastim,SD-01-filgrastim ] pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection