ACTH (4-10) (definition)

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ACTH (4-10)

under Adrenocorticotropic Hormone

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Definition: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).

Other names ACTH; Corticotropin; Adrenocorticotropin; Hormone, Adrenocorticotropic; Hormone, Adrenocorticotrophic; Corticotropin (1-39); Corticotrophin (1-39); Corticotrophin; Adrenocorticotrophic Hormone; ACTH (1-39); 1-39 ACTH

Drugs: ACTHAR ACTH; PURIFIED CORTROPHIN GEL; H.P. ACTHAR GEL; CORTICOTROPIN; ACTHAR GEL-SYNTHETIC;

Substance	CAS Registry & name	Categories	Source	Drugs*
ACTH (4-10) [ 4-10-SEMAX,ACTH (4-10), (D-Arg)-isomer,ACTH (4-10), (D-Met)-isomer,ACTH (4-10), (D-alpha Glu)-isomer,ACTH (4-10), zinc phosphate (1:1) salt,ACTH(4-10),ACTH-MSH (4-10),MSH-ACTH (4-10),Met-Glu-His-Phe-Arg-Trp-Gly ] part of ACTH molecule containing amino acids 4-10 of total 39 amino acid chain; heptapeptide common to MSH & ACTH; RN given refers to glycine cpd	4037-01-8 N-(N-(N(2)-(N-(N-(N-L-methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycine	Adrenocorticotropic Hormone Peptide Fragments Melanocyte-Stimulating Hormones Pharma Action Nootropic Agents	Ann Neurol 1(3):270;1977; Dokl Akad Nauk SSSR 240(5):1245;1978; Eur J Pharmacol 1979:57(4):353; Frontiers Hormone Res 4:129;1976; J Neurochem 32(4):977;1978; Prog Brain Res 42:163;1975; Prog Brain Res 42:187;1975; Prog Brain Res 42:209;1975; Prog Brain Res 42:275;1975; Psychopharmacology (Berlin) 61(2):161;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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