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xylamine

under Nitrogen Mustard Compounds
More information in Books or onNLM PubMed
More on Nitrogen Mustard Compounds Definition: A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.  alkyating antineoplastics; do not confuse with NITROGEN MUSTARD, a specific chemical; DF: NITROGEN MUSTARD CPDS    Other names Mustard Compounds, Nitrogen; Compounds, Nitrogen Mustard
SubstanceCAS Registry & nameCategoriesSourceDrugs*
xylamine [ N-2-chloroethyl-N-ethyl-2-methylbenzylamine ]
  irreversibly inhibits norepinephrine accumulation by rabbit aortic rings in vitro; UD & journal source given agree on structure of cpd; Negwer calls it the bis(2-chloroethyl) cpd 		78686-02-9 Benzenemethanamine, N-(2-chloroethyl)-N-ethyl-2-methyl  *Nitrogen Mustard Compounds Neurotoxins
Pharma Action Sympathomimetics 		J Pharmacol Exp Ther 1980;214(2):324

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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