Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
/antag permitted but consider also DIPHTHERIA ANTITOXIN
Other names Corynebacterium Diphtheriae Toxin; Toxin, Corynebacterium Diphtheriae
insulin crosslinked to the catalytic fragment A of diphtheria toxin [ insulin-diphtheria toxin A chimeric peptide ] Insulin crosslinked to the catalytic fragment A of diphtheria toxin; chimeric insulin is cytotoxic to cells with functioning insulin receptor