Definition: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
leflunomide [ Arava,Aventis Behring Brand of Leflunomide,Aventis Brand of Leflunomide,Aventis Pharma Brand of Leflunomide,HWA 486,HWA-486,Hoechst Brand of Leflunomide,N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide,SU101 ] inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway; antagonizes growth-factor mediated smooth muscle cell proliferation in vitro; structure given in first
