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fulvestrant

under Estradiol
More information in Books or onNLM PubMed
More on Estradiol Definition: Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.      Other names Oestradiol; Estradiol-17 beta; 17 beta-Estradiol; Estradiol Orion Brand; Estradiol 17beta; Estradiol 17 beta; Estradiol 17 alpha; 17 beta Oestradiol; 17 beta Estradiol; Vivelle; Ovocyclin; Orion Brand of Estradiol; Novartis Pharmaceuticals Brand of Estradiol; Estradiol-17beta; Estradiol, Sodium Salt; Estradiol, Monosodium Salt; Estradiol, (9 beta,17 beta)-Isomer; Estradiol, (9 beta,17 alpha)-Isomer; Estradiol, (8 alpha,17 beta)-Isomer; Estradiol, (8 alpha,17 beta)-(+-)-Isomer Drugs: ESTRINGESTRADIOL AND NORGESTIMATE; CLIMARA; PREFEST; ESTRASORB; INNOFEM; ALORA; ESTRACE; ESTRADERM; FEMRING; VIVELLE; GYNODIOL; FEMPATCH; ESTRADIOL; ESTROGEL; ELESTRIN; VIVELLE-DOT; MENOSTAR; EVAMIST; DIVIGEL;
SubstanceCAS Registry & nameCategoriesSourceDrugs*
fulvestrant [ 7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol,AstraZeneca brand of fulvestrant,Faslodex,ICI 182,780,ICI 182780,ICI-182780,ZM 182780,ZM-182780 ]
  structure give in first source; RN given refers to the (7alpha,17beta)-isomer 		129453-61-8   Estradiol/*analogs & derivatives Estrogen Receptor Modulators
Pharma Action Antineoplastic Agents; Estrogen Antagonists; Antineoplastic Agents, Hormonal 		J Cancer Res 1991;51(15):3867 FASLODEX

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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