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Acetyl-CoA Carboxylase

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Definition: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.      Other names Acetyl Coenzyme A Carboxylase; Carboxylase, Acetyl-CoA; Acetyl CoA Carboxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2'-(tert-butyl)-1-(1H-indazole-5-carbonyl)-2'H-spiro(piperidine-4,5'-pyrano(3,2-c)pyrazol)-7'(6'H)-one  0   *Indazoles *Spiro Compounds Acetyl-CoA Carboxylase. J Med Chem. 2012 Jan 26;55(2):935-42.
BCCP2 protein, Arabidopsis  EC 6.4.1.2   *Acetyl-CoA Carboxylase *Arabidopsis Proteins Protein Subunits. Plant Physiol 2011 Jan;155(1):293-314
accD protein, E coli  EC 6.4.1.2   *Acetyl-CoA Carboxylase *Escherichia coli Proteins Fatty Acid Synthetase Complex, Type II.
accC protein, E coli  EC 6.4.1.2   *Acetyl-CoA Carboxylase *Escherichia coli Proteins Fatty Acid Synthetase Complex, Type II.
accA protein, E coli  EC 6.4.1.2   *Acetyl-CoA Carboxylase *Escherichia coli Proteins Fatty Acid Synthetase Complex, Type II.
N-(3-(4-(6-isopropoxypyridin-3-yloxy)phenyl)-1-methylpropyl)acetamide  0   *Acetamides *Pyridines Acetyl-CoA Carboxylase/antagonists & inhibitors. J Med Chem 2010 Dec 23;53(24):8679-87
tepraloxydim  0   *Oximes *Cyclohexanones Acetyl-CoA Carboxylase. Proc Natl Acad Sci U S A 2009 Dec 8;106(49):20723-7
2-(2-chlorobenzylamino)-1-(cyclohexylmethyl)-1H-benzo(d)imidazole-5-carboxamide  0   *Benzimidazoles Acetyl-CoA Carboxylase/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 1;19(23):6507-14
2-(2-chlorobenzylamino)-1-(2,3-dihydro-1H-inden-1-yl)-1H-imidazo(4,5-b)pyridine-5-carboxamide  0   *Imidazoles *Nicotinic Acids Acetyl-CoA Carboxylase/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 1;19(23):6507-14
benzofuranyl alpha-pyrone  0   *Benzofurans *Pyrones Acetyl-CoA Carboxylase/antagonists & inhibitors. Arch Biochem Biophys 2007 Dec 1;468(1):44-8
ACACB protein, human  EC 6.4.1.2   *Acetyl-CoA Carboxylase. J Biol Chem 1997 Apr 18;272(16):10669-77
Acacb protein, mouse  EC 6.4.1.2   *Acetyl-CoA Carboxylase. Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1384-9
tralkoxydim  0   *Cyclohexanones *Imines Acetyl-CoA Carboxylase/antagonists & inhibitors. J Agric Food Chem 1999 Jan;47(1):299-304
2-(1-(allyloxyimino)propyl)-3-hydroxy-5-(1-(2,3-dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl))cyclohex-2-en-1-one  0   *Benzofurans *Cyclohexanones Acetyl-CoA Carboxylase/antagonists & inhibitors. Pest Manag Sci 2004 Sep;60(9):909-13
moiramide B  0   *Amides *Succinimides Acetyl-CoA Carboxylase/antagonists & inhibitors. J Biol Chem 2004 Jun 18;279(25):26066-73
2,4-dihydroxyheptadec-16-ynyl acetate  0   *Fatty Acids, Unsaturated Acetyl-CoA Carboxylase/antagonists & inhibitors. Biosci Biotechnol Biochem 2001 Jul;65(7):1656-8
2,4-dihydroxyheptadec-16-enyl acetate  0   *Fatty Acids, Unsaturated Acetyl-CoA Carboxylase/antagonists & inhibitors. Biosci Biotechnol Biochem 2001 Jul;65(7):1656-8
2-hydroxy-4-oxoheneicosa-5,12,15-trienyl acetate  0   *Fatty Acids, Unsaturated Acetyl-CoA Carboxylase/antagonists & inhibitors. Biosci Biotechnol Biochem 2001 Jul;65(7):1656-8
clodinafop  0   *Propionates *Pyridines Acetyl-CoA Carboxylase/antagonists & inhibitors. Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13387-92
biotin carboxyl carrier protein (70-156)  0   *Carrier Proteins *Peptide Fragments Acetyl-CoA Carboxylase. J Biol Chem 1997 Oct 10;272(41):26017-22
Se-Met-BCCPsc protein, recombinant  0   *Acetyl-CoA Carboxylase *Peptide Fragments *Recombinant Proteins. Structure 1995 Dec 15;3(12):1407-19
BCCPsc protein, recombinant  0   *Acetyl-CoA Carboxylase *Peptide Fragments *Recombinant Proteins Carrier Proteins. Structure 1995 Dec 15;3(12):1407-19
HFA1 protein, S cerevisiae  EC 6.4.1.2   *Acetyl-CoA Carboxylase *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins. DNA Seq 1993;4(1):69-70
biotin carboxyl carrier protein  EC 6.4.1.2   *Acetyl-CoA Carboxylase Fatty Acid Synthetase Complex, Type II. Biotechniques 1993 Feb;14(2):209-12
tetradecanylglutarate  41240-22-6   *Glutarates Acetyl-CoA Carboxylase/antagonists & inhibitors. J Antibiot (Tokyo) 1986;39(2):275
5'-adenylyl (beta,gamma-bromomethylene)diphosphonate  0   Adenosine Triphosphate/*analogs & derivatives Acetyl-CoA Carboxylase/antagonists & inhibitors. Bioorg Khim 1985;11(5):598
5'-adenylyl (alpha,beta-bromomethylene)diphosphonate  97474-27-6   Adenosine Triphosphate/*analogs & derivatives Acetyl-CoA Carboxylase/antagonists & inhibitors. Bioorg Khim 1985;11(5):598

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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