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Acyclovir

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Definition: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.     
Pharmacological Action Antiviral Agents
Examples Ganciclovir 		Other names Acycloguanosine; Milavir; Menarini Brand of Aciclovir Sodium Salt; Menarini Brand of Aciclovir; Maynar; Mapox; Mann Brand of Aciclovir; Liomont Brand of Aciclovir; Lichtenstein Brand of Aciclovir; Laciken; Kendrick Brand of Aciclovir; Isis Brand of Aciclovir; Isavir; Hexal Brand of Aciclovir Sodium Salt; Hexal Brand of Aciclovir; Herpoviric; Herpotern; Herpofug; Herpetad; Gr++nenthal Brand of Aciclovir Sodium SaltDrugs* : ACYCLOVIR; ZOVIRAX; ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE; ACYCLOVIR SODIUM; XERESE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ME 609  0   *Acyclovir *Hydrocortisone Drug Combinations. J Am Acad Dermatol 2011 Apr;64(4):696.e1-11
acycloguanosine H-phosphonate  0   *Phosphonic Acids Acyclovir/*analogs & derivatives. Vopr Virusol. 2010 Jan-Feb;55(1):31-4
tyrosylacyclovir  0   Acyclovir/*analogs & derivatives Tyrosine/*analogs & derivatives. Curr Eye Res 2004 Aug-Sep;29(2-3):153-66
gamma-glutamylacyclovir  0   Acyclovir/*analogs & derivatives Glutamic Acid/*analogs & derivatives. Curr Eye Res 2004 Aug-Sep;29(2-3):153-66
val-valacyclovir  0   Acyclovir/*analogs & derivatives Valine/*analogs & derivatives. Curr Eye Res 2002 Oct;25(4):243-52
8-fluoropenciclovir  0   Acyclovir/*analogs & derivatives. J Nucl Med. 2001 Jan;42(1):96-105
1-O-hexadecylpropanediol-3-phosphoacyclovir  0   Acyclovir/*analogs & derivatives. Antimicrob Agents Chemother 2000 Jul;44(7):1964-9
acyclovir-5'-(phenyl methoxy alaninyl)phosphate  0   Acyclovir/*analogs & derivatives. Bioorg Med Chem Lett 2000 Apr 3;10(7):645-7
1-O-hexadecylpropanediol-3-p-acyclovir  0   Acyclovir/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2000 Jan-Feb;19(1-2):471-9
3-methyl-cyclosal-PCVMP  0   Acyclovir. Nucleosides Nucleotides 1999 Apr-May;18(4-5):943-4
guanin-9-yl methyloxy-2-ethyl bis(S-pivaloyl-2-thioethyl) phosphate  0   *Phosphonic Acids Acyclovir/*analogs & derivatives. Antiviral Res 1999 Jan;40(3):167-782
guanin-9-yl methyloxy-2-ethyl bis(S-acetyl-2-thioethyl) phosphate  0   *Phosphonic Acids Acyclovir. Antiviral Res 1999 Jan;40(3):167-78
acyclovir beta-glucoside  0   *Glucosides Acyclovir/*analogs & derivatives. Pharm Res 1999 Jan;16(1):69-73
9-(2'-(9''-octadecenoyloxy)ethoxymethyl)guanine  0   *Oleic Acids Acyclovir/*analogs & derivatives. Antimicrob Agents Chemother 1999 Jan;43(1):53-61
diamminechloro(9-(2-hydroxyethoxymethyl)guan-7-yl)platinum(II)  0   *Organoplatinum Compounds Acyclovir/*analogs & derivatives. Mol Pharmacol 1998 May;53(5):801-7
acyclovir fluorophosphate  0   Acyclovir/*analogs & derivatives. Bioorg Khim 1997 Nov;23(11):906-9
acyclovir phosphite  0   Acyclovir/*analogs & derivatives. Bioorg Khim 1997 Nov;23(11):906-9
6-deoxypenciclovir  0   Acyclovir/*analogs & derivatives. Drug Metab Dispos 1997 Jul;25(7):805-13
1-O-octadecyl-sn-glycero-3-phospho-acyclovir  0   Acyclovir/*analogs & derivatives. Biochem Pharmacol 1997 Jun 15;53(12):1815-22
3,9-dihydro-3-((2-hydroxyethoxy)methyl)-6-ethyl-9-oxo-5H-imidazo(1,2-a)purine  0   Acyclovir/*analogs & derivatives. J Biomol NMR 1996 Oct;8(3):261-72
penciclovir triphosphate  0   Acyclovir/*analogs & derivatives DNA-Directed DNA Polymerase/antagonists & inhibitors. Biochemistry 1995 Feb 28;34(8):2504-10
acyclovir diphosphate dimyristoylglycerol  139701-81-8   *Phosphatidylglycerols Acyclovir/*analogs & derivatives. Proc Natl Acad Sci U S A 1993 Dec 15;90(24):11835-9
valacyclovir  124832-27-5   Acyclovir/*analogs & derivatives Valine/*analogs & derivatives Prodrugs.
Pharma Action Antiviral Agents 		J Med Virol 1993;Suppl 1:139-45VALACYCLOVIR HYDROCHLORIDE; VALTREX
BRL 42359  104227-86-3 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)  Acyclovir/*analogs & derivatives. Drug Metab Dispos Biol Fate Chem 1993 Jan-Feb;21)1):18-23
bis(2-(guanin-9-ylmethoxy)ethoxy)-4-(methylsulfonyl)phenyl phosphate  125440-27-9   Acyclovir/*analogs & derivatives. J Med Chem 1990;33(5):1400
acyclovir monophosphate-lactosaminated serum albumin conjugate  0   *Serum Albumin Acyclovir/*analogs & derivatives. Naturwissenschaften 1989;76(2):74
bucyclovir triphosphate  108491-46-9   Acyclovir/*analogs & derivatives. Antimicrob Agents Chemother 1988;32(8):1137
9-(4-hydroxy-2-(hydroxymethyl)butyl)-guanine triphosphate  117191-32-9   Acyclovir/*analogs & derivatives. Antimicrob Agents Chemother 1988;32(8):1137
BIOLF 143  92519-15-8 Methanimidamide, N'-(6,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-oxo-1H-purin-2-yl)-N,N-dimethyl  Acyclovir/*analogs & derivatives. Fundam Appl Toxicol 1988;10(2):313
penciclovir  39809-25-1   Acyclovir/*analogs & derivatives Reverse Transcriptase Inhibitors.
Pharma Action Antiviral Agents 		Antimicrob Agents Chemother 1987;31(8):1238DENAVIR
9-((1,3-dihydroxy-2-propylthio)methyl)guanine  97151-23-0   Acyclovir/*analogs & derivatives. J Med Chem 1985;28(9):1242
desciclovir  84408-37-7 Ethanol, 2-((2-amino-9H-purin-9-yl)methoxy)  Acyclovir/*analogs & derivatives Prodrugs.
Pharma Action Antiviral Agents 		Natl Proc Acad Sci USA 1984;81(10):3209
2'-O-glycyl acyclovir  84499-62-7   Acyclovir/*analogs & derivatives. Arch Ophthalmol 1984;102(1):140
9-(4-hydroxybutyl)guanine  23169-37-1   Acyclovir/*analogs & derivatives. Antiviral Res 1983;3(2):77
2,6-diamino-9-(2-hydroxyethoxymethyl)purine  59277-86-0 Ethanol, 2-((2,6-diamino-9H-purin-9-yl)methoxy)  Acyclovir/*analogs & derivatives. Biochem Pharmacol 1983;32(17):2463
9-(3,4-dihydroxybutyl)guanine  83470-64-8 6H-Purin-6-one, 2-amino-9-(3,4-dihydroxybutyl)-1,9-dihydro  Acyclovir/*analogs & derivatives. Antimicrob Agents Chemother 1983;23(5):664
acyclovir monophosphate  66341-16-0   Acyclovir/*analogs & derivatives. J Biol Chem 11980;255(15):7204
acyclovir triphosphate  66341-18-2 triphosphoric acid, P-(2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl) ester  Acyclovir/*analogs & derivatives DNA Polymerase II/antagonists & inhibitors.
Pharma Action Antiviral Agents ; Enzyme Inhibitors 		J Biol Chem 1980;255(11):5120
9-((2-aminoethoxy)methyl)guanine  79353-04-1 6H-Purin-6-one, 2-amino-9-((2-aminoethoxy)methyl)-1,9-dihydro  Acyclovir/*analogs & derivatives. J Med Chem 1981;24(12):1528

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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