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Adenosine

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Definition: A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.  /biosyn /physiol permitted   
Pharmacological Action Analgesics; Anti-Arrhythmia Agents; Vasodilator Agents
Examples Adenosine-5'-(N-ethylcarboxamide); S-Adenosylhomocysteine; S-Adenosylmethionine; 2-Chloroadenosine; Deoxyadenosines; Isopentenyladenosine; Phenylisopropyladenosine; Puromycin; Vidarabine 		Other names AdenocardDrugs* : ADENOSCAN; ADENOCARD; ADENOSINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-ethylthio-6-phenethylaminoadenosine  0   Adenosine/*analogs & derivatives. Thromb Haemost. 2011 Dec;106(6):1203-14.
2-(6-amino-2-(hex-1-enyl)-9H-purine-9-yl)tetrahydrothiophene-3,4-diol  0   *Thiophenes Adenosine/*analogs & derivatives Adenosine A2 Receptor Agonists Adenosine A3 Receptor Antagonists. J Med Chem. 2012 Jan 12;55(1):342-56
2-(6-amino-2-(hex-1-ynyl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol  0   *Thiophenes Adenosine/*analogs & derivatives Adenosine A2 Receptor Agonists Adenosine A3 Receptor Antagonists. J Med Chem. 2012 Jan 12;55(1):342-56
NGF 1568  0   Adenosine/*analogs & derivatives. Xenobiotica. 2011 Nov;41(11):934-44.
2'-C-methyladenosine  0   Adenosine/*analogs & derivatives Hepacivirus/drug effects. Hepatology. 2011 Dec;54(6):1913-23
2'-fluoro-6'-methylene-carbocyclic adenosine  0   Adenosine/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6328-31
4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro(2.4)heptane-5,6-diol  0   *Spiro Compounds Adenosine/*analogs & derivatives. Bioorg Med Chem Lett 2011 Jul 1;21(13):3982-5
AR C124910XX  0   Adenosine/*analogs & derivatives. Eur J Clin Pharmacol 2010 May;66(5):487-96
O2',O3',O5'-triacetyl-N6-(3-hydroxylaniline)adenosine  0   Adenosine/*analogs & derivatives AMP-Activated Protein Kinases. Lipids Health dis 2011;10:67
(3beta-C-fluoromethyl-beta-D-ribofuranosyl)-N6-methyladenine  0   Adenosine/*analogs & derivatives. Bioorg Med Chem. 2010 Jul 1;18(13):4812-20
(3betaC-fluoromethyl-beta-D-ribofuranosyl)adenine  0   Adenosine/*analogs & derivatives. Bioorg Med Chem. 2010 Jul 1;18(13):4812-20
2'-O-(3-(furan-2-yl)propyl)adenosine  0   *Furans Adenosine/*analogs & derivatives. Chem Commun (Camb). 2011 Mar 14;47(10):2796-8
UK-432097  0   Adenosine/*analogs & derivatives Adenosine A2 Receptor Agonists. Science. 2011 Apr 15;332(6027):322-7
dehydrosinefungin V  0   Adenosine/*analogs & derivatives. J Antibiot (Tokyo) 2010 Nov;63(11):673-9
sinefungin VA  0   Adenosine/*analogs & derivatives. J Antibiot (Tokyo) 2010 Nov;63(11):673-9
2Cl-C.OXT-A  0   Adenosine/*analogs & derivatives. Biochem Biophys Res Commun 2010 Sep 3;399(4):699-704
2-chloro-6-cyclohexylamino-9-(3,4-dihydroxy-5-methyltetrahydrothiophene-2-yl)purine  0   *Thiophenes Adenosine/*analogs & derivatives. Chem Biol Drug Des 2010 Jun;75(6):619-27
2-chloro-6-cyclopentylamino-9-(3,4-dihydroxy-5-methyltetrahydrothiophene-2-yl)purine  0   *Thiophenes Adenosine/*analogs & derivatives. Chem Biol Drug Des 2010 Jun;75(6):619-27
2-(1-ethynylpyrene)adenosine  0   *Pyrenes Adenosine/*analogs & derivatives. Chembiochem 2010 Mar 22;11(5):664-72
N-(9-deazaadenin-9-yl)methyl-1,4-dideoxy-1,4-iminoribitol  0   Adenosine/*analogs & derivatives. Antimicrob Agents Chemother 2010 May;54(5):1900-8
1-(erythrofuranosyl)adenosine  0   Adenosine/*analogs & derivatives. Acta Crystallogr C 2010 Apr;66(Pt 4):e215-8
N6-(2-amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahydrothieno(2,3-c)pyridin-6-yl-9-nonyloxy-4-phenyl)adenosine  0   Adenosine/*analogs & derivatives Ligands. J Med Chem 2010 Apr 22;53(8):3028-37
adenosine 2-aminosuccinic acid-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol  0   Adenosine/*analogs & derivatives. Int J Biochem Cell Biol 2010 Feb;42(2):287-96
4'-(2-chloro-6-(3-iodobenzylamino)purine)-2',3'-O-dihydroxy-bicyclo(3.1.0)hexane  0   Adenosine/*analogs & derivatives Iodine Radioisotopes Receptor, Adenosine A3/agonists. Biochem Pharmacol 2010 Apr 1;79(7):967-73
GW 328267  0   *Triazoles Adenosine/*analogs & derivatives Receptor, Adenosine A2A/agonists. Bioorg Med Chem Lett 2009 Aug 1;19(15):4471-5
8-methyl-5'-((4-aminobut-2-enyl)(methylamino))adenosine  0   Adenosine/*analogs & derivatives. Antimicrob Agents Chemother 2009 Aug;53(8):3269-72
S-adenosyl-N-decyl-aminoethyl  0   Adenosine/*analogs & derivatives. J Biol Chem 2009 Jul 17;284(29):19321-30
5''-iodoneplanocin A  0   Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2008;(52):653-4
9-(5-deoxyseptanosyl)adenine  0   Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2008;(52):611-2
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester  0   Adenosine/*analogs & derivatives. Drug Metab Dispos 2009 Mar;37(3):560-13
ARC 1034  0   *Dipeptides Adenosine/*analogs & derivatives Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. J Med Chem 2009 Jan 22;52(2):308-21
4'-methylcyclopentanyl 9-deazaadenosine  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2008 Oct;27(10):1144-52
4'-selenoadenosine  0   *Organoselenium Compounds Adenosine/*analogs & derivatives. Carbohydr Res 2008 Jul 21;343(10-11):1790-800
CF 502  0   Adenosine/*analogs & derivatives Receptor, Adenosine A3/agonists. Biochem Pharmacol 2008 Aug 15;76(4):482-94
ARC 341  0   *Oligopeptides Adenosine/*analogs & derivatives. FEBS J 2008 Jul;275(14):3608-24
3',4'-epoxynoraristeromycin  0   Adenosine/*analogs & derivatives. Bioorg Med Chem. 2008 Jul 1;16(13):6575-9
8-bromo-2-aminoadenosine  0   Adenosine/*analogs & derivatives. J Phys Chem B 2008 Apr 24;112(16):5209-17
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G  0   *Pyrrolidines Adenosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2008 Feb 26;47(8):2559-64
5'-(tributyltin)-2',3'-O-isopropylidene-4'-trityladenosine  0   *Organotin Compounds Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2007;(51):145-6
N6-(2-hydroxyethyl)adenosine  0   Adenosine/*analogs & derivatives. Luminscence 2007 Nov-Dec;22(6):
kinetin riboside  0   *Adenosine *Kinetin. Cancer Lett 2008 Mar 8;261(1):37-45
ABEA-X-BY630  0   *Boron Compounds Adenosine/*analogs & derivatives Receptor, Adenosine A3/agonists. FASEB J 2008 Mar;22(3):850-60
2'-O-carbomoylmethyladenosine 3'-(thymidine 5'-phosphate)  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1495-9
2',3',5'-tri-O-acetyl-2-amino(-N6-cyclopentyl)-1-deazaadenosine  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1439-42
2',3',5'-tri-O-acetyl-2-amino-1-deazaadenosine  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1439-42
1'-C-fluoromethyladenosine  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1431-4
5'-O-(N-(salicyl)sulfamoyl)adenosine  0   Adenosine/*analogs & derivatives. J Med Chem 2007 Nov 29;50(24):6080-94
homo-apioneplanocin A  0   Adenosine/*analogs & derivatives Adenosylhomocysteinase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2007;26(6-7):729-32
3'-ethynyladenosine  0   Adenosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2007;26(6-7):691-4
5-((bis-(3-aminopropyl)amino)acetamido-1-propynyl)adenosine  0   Adenosine/*analogs & derivatives. Bioorg Med Chem. 2007 Dec 1;15(23):7426-33
aspartycin  0   Adenosine/*analogs & derivatives Aspartic Acid/*analogs & derivatives. Biochemistry 2007 Nov 13;46(45):13190-8
4'-azidoadenosine  0   *Azides Adenosine/*analogs & derivatives. J Med Chem 2007 Nov 1;50(22):5463-70
N(6)-(4-(2-(1,1,3,3-tetramethylisoindolin-2-yloxyl-5-amido)ethyl)phenyl)adenosine  0   *Isoindoles Adenosine/*analogs & derivatives. Bioorg Med Chem Lett 2007 Oct 1;17(19):5437-41
N(6)-(2,2,5,5-tetramethylpyrrolidin-1-yloxyl-3-ylmethyl)adenosine  0   *Pyrrolidines Adenosine/*analogs & derivatives. Bioorg Med Chem Lett 2007 Oct 1;17(19):5437-41
selodenoson  0   Adenosine/*analogs & derivatives Receptor, Adenosine A1/agonists. Expert Rev Cardiovasc Ther 2007 Jul;5(4):707-14
7,9-dideaza-7-oxa-2'-C-methyladenosine  0   Adenosine/*analogs & derivatives. Bioorg Med Chem 2007 Aug 1;15(15):5219-29
2'-(4,5',8-trimethylpsoralen-4-yl)adenosine  0   *Psoralens Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2006;(50):301-2
N-(phenylcarboxamido)adenosine  0   *Phenylurea Compounds Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2006;(50):201-2
N-(5-(6-(2-(4-methylpyridin-2-yl)pyridin-4-yl)hexanamido)pentyl)adenosine  0   Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2006;(50):129-30
4'-(2,2-difluorospirocyclopropane) adenosine  0   *Hydrocarbons, Fluorinated *Spiro Compounds Adenosine/*analogs & derivatives. J Org Chem 2007 Feb 2;72(3):8876-83
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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