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Adenosine Deaminase

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Definition: An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.  /defic: consider also SEVERE COMBINED IMMUNODEFICIENCY or SCID    Other names Adenosine Aminohydrolase; Deaminase, Adenosine; Aminohydrolase, Adenosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Adar protein, Drosophila  EC 3.5.4.4   *Adenosine Deaminase *Drosophila Proteins RNA-Binding Proteins. RNA 2000 Jul;6(7):1004-18
ADAR2 protein, human  EC 3.5.4.4   *Adenosine Deaminase *RNA-Binding Proteins. Nucleic Acids Res 2011 Sep 1;39(16):7249-62
Ada protein, rat  EC 3.5.4.4   Membrane Proteins *Adenosine Deaminase.
Ada protein, mouse  EC 3.5.4.4   *Adenosine Deaminase.
ADA protein, human  EC 3.5.4.4   *Adenosine Deaminase.
Severe combined immunodeficiency due to adenosine deaminase deficiency  0   *Agammaglobulinemia *Severe Combined Immunodeficiency Adenosine Deaminase/deficiency.
CECR1 protein, Xenopus  0   *Xenopus Proteins Adenosine Deaminase. J Biol Chem 2008 Jan 25;283(4):2255-64
TadA protein, E coli  EC 3.5.4.4   *Adenosine Deaminase *Escherichia coli Proteins. Biochemistry 2006 May 23;45(20):6407-16
2-(2-hydroxydecyl)-4-aminopyrazolo(3,4-d)pyrimidine  0   *Pyrazoles *Pyrimidines Adenosine Deaminase/antagonists & inhibitors. J Med Chem 2005 Aug 11;48(16):5162-74
adenosine deaminase-complexing protein, Oryctolagus cuniculus  EC 3.4.14.5   *Adenosine Deaminase *Glycoproteins Isoenzymes.
1-(4-(5-(3-(4-chlorophenyl)propoxy)-1-methylindol-3-yl)-1-hydroxy-2-butyl)imidazole-4-carboxamide  0   *Indoles *Imidazoles Adenosine Deaminase/antagonists & inhibitors. J Med Chem 2004 Jul 15;47(15):3730-43
Adr-2 protein, C elegans  EC 3.5.4.4   *Adenosine Deaminase *Caenorhabditis elegans Proteins. EMBO J 2002 Nov 15;21(22):6025-35
Adr-1 protein, C elegans  EC 3.5.4.4   *Adenosine Deaminase *Caenorhabditis elegans Proteins. EMBO J 2002 Nov 15;21(22):6025-35
CECR1 protein, human  EC 3.5.4.4   *Adenosine Deaminase *Intercellular Signaling Peptides and Proteins. Genomics 2000 Mar 15;64(3):277-85
1-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide  0   *Fatty Alcohols *Triazoles Adenosine Deaminase/antagonists & inhibitors. Farmaco 1997 Jun-Jul;52(6-7):429-33
5-(formylamino)imidazole riboside  0   *Imidazoles Ribose/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1997 Oct 10;40(21):3336-45
dsRNA adenosine deaminase  EC 3.5.4.-   *Adenosine Deaminase DNA-Binding Proteins RNA Editing. J Biol Chem 1994 Apr 1;269(13):9933-9
1-(2-hydroxy-3-nonyl)-1,2,4-triazole  152343-82-3   *Triazoles Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1994 Jan 7;37(1):201-5
1-(2-hydroxy-3-nonyl)imidazole-4-carboxamide  130573-54-5   Aminoimidazole Carboxamide/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1991;34(3):1187
1,3-dideaza-9-(2-hydroxy-3-nonyl)adenine  103298-52-8   Adenine/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1988;31(2):390
7-deaza-9-(2-hydroxy-3-nonyl)adenine  103298-51-7   Adenine/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1988;31(2):390
pegademase bovine  EC 3.5.4.-   *Adenosine Deaminase Drug Carriers Severe Combined Immunodeficiency. N Engl J Med 1987;316(10):589ADAGEN
adecypenol  104493-13-2   *Cyclopentanes *Purines Adenosine Deaminase/antagonists & inhibitors. J Antibiot (Tokyo) 1986;39(2):309
9-(1-hydroxy-2-octyl)adenine  20776-39-0   Adenine/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. Ann NY Acad Sci 1985;451:215
(1-hydroxyethyl)-5-methyl-1-beta-ribofuranosylimidazole  98483-26-2   *Ribonucleosides Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1985;28(11):1751
adechlorin  96328-17-5 Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-chloro-2-deoxy-beta-D-ribofuranosyl)-3,4,7,8-tetrahydro-, (R)  Pentostatin/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Antibiot (Tokyo) 1985;38(8):1008
9-(2-hydroxy-3-nonyl)-3-deazaadenine  87871-09-8   Adenine/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1984;27(3):274
9-(2-hydroxy-3-nonyl)-1-deazaadenine  87871-08-7   Adenine/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1984;27(3):274
3,6,7,8-tetrahydro-3-((2-hydroxyethoxy)methyl)imidazo(4,5-d)(1,3)diazepin-8-ol  86646-88-0   Coformycin/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1983;26(10):1478
1,6-dihydro-6-(hydroxymethyl)-9-(2-hydroxy-3-nonyl)purine  81129-37-5 9H-Purine-9-ethanol, beta-hexyl-1,6-dihydro-6-(hydroxymethyl)-alpha-methyl-, (6R*,9(alphaS*,betaR*))-(+-)  *Purines Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1982;25(5):603
thymus-leukemia antigens  0   *Membrane Glycoproteins Adenosine Deaminase Antigens, Neoplasm Antigens, Viral, Tumor T-Lymphocytes Thymus Gland. Biochemistry 1980;19(24):5659; Cancer Res 1982;42(10):4259

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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