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Adenosine Kinase

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Definition: An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a salvage mechanism for returning adenosine to nucleic acids. EC 2.7.1.20.      Other names Kinase, Adenosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-ethyl-6-(4-((phenylthio)methyl)phenyl)-6,7-dihydrobenzo(b)pyrrolo(1,2-d)(1,4)oxazepin-7-one  0   *Oxazepines *Pyrroles Adenosine Kinase/antagonists & inhibitors. J Med Chem 2011 Mar 10;54(5):1401-20
5-iodo-5'-deoxytubercidin  0   Tubercidin/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2006 Nov 16;49(23):6726-31
5-(4-(dimethylamino)phenyl)-6-(6-morpholin-4-ylpyridin-3-ylethynyl)pyrimidin-4-ylamine  0   *Morpholines *Pyrimidines Adenosine Kinase/antagonists & inhibitors. J Med Chem 2006 Nov 16;49(23):6726-31
4-N-(N-cyclopropylcarbamoylmethyl)amino-5-phenyl-7-(5-deoxyribofuranosyl)pyrrolo(2,3-d)pyrimidine  0   *Nucleosides Adenosine Kinase/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7808-20
4-N-(4-fluorophenyl)amino-5-phenyl-7-furanosylpyrrolo(2,3-d)pyrimidine  0   Adenosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2005 Oct 6;48(20):6430-41
8-anilin-N-yl-6-indolin-N-yl-9-ribofuranosylpurine  0   *Indoles *Purine Nucleosides Adenosine Kinase/antagonists & inhibitors. J Med Chem 2005 May 5;48(9):3389-99
6-(2,4-dichlorobenzylthio)-9-ribofuranosylpurine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
6-(4-cyanobenzylthio)-9-ribofuranosylpurine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
6-benzylthioinosine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
5-phenyl-4-N-phenylamino-7-lyxofuranosylpyrrolo(2,3-d)pyrimidine  0   *Nucleosides Adenosine Kinase/antagonists & inhibitors. J Med Chem 2003 Oct 23;46(22):4750-60
5'-deoxy-5'-amino-clitocine  0   *Pyrimidine Nucleosides Adenosine Kinase. Bioorg Med Chem Lett 2001 Sep 17;11(18):2419-22
A 134974  0   *Nucleosides Adenosine Kinase/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Feb;296(2):501-9
GP 515  0   *Formycins Adenosine Kinase/antagonists & inhibitors. Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2116-23
ABT 702  0   *Morpholines *Pyrimidines Adenosine Kinase/antagonists & inhibitors. J Pharmacol Exp Ther 2000 Dec;295(3):1156-64
GP 683  0   *Pyrimidines Adenosine Kinase/antagonists & inhibitors. Anesth Analg 1997 Sep;85(3):675-80
GP 1-515  144928-48-3   *Ribonucleosides Adenosine Kinase/antagonists & inhibitors. J Immunol 1994 Jun 15;152(12):5853-9
5'-amino-5'-deoxyadenosine  14365-44-7   *Deoxyadenosines Adenosine Kinase/antagonists & inhibitors. J Cell Physiol 1988;137(3):565
5'-deoxy-5-iodotubercidin  0   Tubercidin/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. Biochem Pharmacol 1984;33(3):347
4-amino-5-bromopyrrolo(2,3-d)pyrimidine  0   Adenine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. Biochem Pharmacol 1984;33(3):347
5-iodotubercidin  24386-93-4   Tubercidin/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem J 1981;200(2):399

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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