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Adrenergic alpha-Antagonists

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Definition: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.  GEN or unspecified; prefer specifics; do not confuse with ADRENERGIC ALPHA-AGONISTS; DF: ADREN ALPHA ANTAG   
Examples Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists 		Other names alpha-Blockers, Adrenergic; alpha-Adrenergic Receptor Blockaders; alpha-Adrenergic Blocking Agents; Adrenergic alpha-Receptor Blockaders; alpha-Receptor Blockaders, Adrenergic; alpha-Antagonists, Adrenergic; alpha Blockers, Adrenergic; alpha Adrenergic Receptor Blockaders; alpha Adrenergic Blocking Agents; alpha Adrenergic Blockers; Receptor Blockaders, alpha-Adrenergic; Blocking Agents, alpha-Adrenergic; Blockers, alpha-Adrenergic; Blockaders, alpha-Adrenergic Receptor; Blockaders, Adrenergic alpha-Receptor; Agents, alpha-Adrenergic Blocking; Adrenergic alpha Receptor Blockaders; Adrenergic alpha Blockers; Adrenergic alpha Antagonists; alpha-Adrenergic Blockers
Substances having this pharmacologic action: BE 2254; (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; ifenprodil; arotinolol; medroxalol; benextramine; phenylpiperazine; midaglizole; amosulalol; AR-C239; mirtazapine; K 351; 1-(2-pyrimidinyl)piperazine; benalfocin; proroxan; EEDQ; Piperoxan; Dibenzylchlorethamine; Nicergoline; Quinidine; Moxisylyte; Tolazoline; Dihydroergotoxine; Ergoloid Mesylates; Mianserin; Phenoxybenzamine; Phentolamine; 1-benzylimidazole; monatepil; BRL 44408; efaroxan; naftopidil; dapiprazole; BMY 7378; L 657743; SK&F 104078; 5-methylurapidil; 2-methoxyidazoxan; 2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone; 7,8-(methylenedioxy)-14-hydroxyberbane; benoxathian; chlorethylclonidine; YM 12617
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(4-amino-6,7-dimethoxy-2--quinazolyl)-4-(4-(bis-2-chloroethylamino)benzoyl)piperazine  0   Prazosin/*analogs & derivatives Adrenergic alpha-Antagonists. Bioorg Med Chem 1995 Feb;3(2):173-8
emakor  0   Organic Chemicals Adrenergic alpha-Antagonists. Ter Arkh 1992;64(1):44-6
buflomedil  55837-25-7 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone  *Pyrrolidines Adrenergic alpha-Antagonists Platelet Aggregation Inhibitors.
Pharma Action Vasodilator Agents 		Sem Hop Paris 1980;56(9-10):490; Therapie 30(2):207;1975; Therapie 30(2):259;1975; Therapie 33(3):321;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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