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Alcohol Oxidoreductases

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Definition: A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).     
Examples Acetoin Dehydrogenase; Alcohol Dehydrogenase; Carbohydrate Dehydrogenases; Choline Dehydrogenase; Galactose Oxidase; Glucose Oxidase; Homoserine Dehydrogenase; 3-Hydroxyacyl CoA Dehydrogenases; Hydroxybutyrate Dehydrogenase; Hydroxyprostaglandin Dehydrogenases; Hydroxypyruvate Reductase; Hydroxysteroid Dehydrogenases; IMP Dehydrogenase; Isocitrate Dehydrogenase; 3-Isopropylmalate Dehydrogenase; Ketol-Acid Reductoisomerase; Lactate Dehydrogenases; Malate Dehydrogenase; Malate Dehydrogenase (NADP+); Xanthine Dehydrogenase; Xanthine Oxidase
Other names Reductases, Ketone; Reductases, Carbonyl; Oxidoreductases, Alcohol; Ketone Reductases; Carbonyl Reductases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PLR1 protein, Arabidopsis  EC 1.1.1.65   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant Mol Biol. 2011 May;76(1-2):157-69
MFE-2 protein, Drosophila  0   *Alcohol Oxidoreductases *Multienzyme Complexes *Carbon-Oxygen Lyases *Drosophila Proteins. Biochem J 2011 May 1;435(3):771-81
D2HGDH protein, human  EC 1.1.99.2   *Alcohol Oxidoreductases Mitochondrial Proteins. Neuropathol Appl Neurobiol. 2011 Apr;37(3):330-2
At2g37770 protein, Arabidopsis  EC 1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. J Biol Chem 2011 Mar 4;286(9):6999-709
Dhrs3 protein, Xenopus  EC 1.1.-   *Alcohol Oxidoreductases *Xenopus Proteins. Int J Dev Biol. 2010;54(8-9):1355-60
carbonyl reductase 1, mouse  EC 1.1.-   *Alcohol Oxidoreductases. Free Radic Biol Med 2010 Nov 30;49(10):1522-33
5-chloro-5-deoxy-D-ribose 1-dehydrogenase, Salinispora tropica  EC 1.1.-   *Alcohol Oxidoreductases. J Biol Chem 2010 Oct 29;285(44):33710-7
U4kpxs protein, Ralstonia solanacearum  0   *Alcohol Oxidoreductases *Carboxy-Lyases *Multienzyme Complexes. J Biol Chem 2010 Mar 19;285(12):9030-40
Dhrs3a protein, zebrafish  EC 1.1.-   *Alcohol Oxidoreductases *Zebrafish Proteins. Dev Biol 2010 Feb 1;338(1):1-14
SDRa protein, Arabidopsis  EC 1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant Mol Biol 2009 Mar;69(5):503-15
4-dihydrotrisporin dehydrogenase, Mucor mucedo  EC 1.1.1.-   *Alcohol Oxidoreductases. Eukaryot Cell 2009 Jan;8(1):88-95
menthone (3S)-neomenthol reductase, Arabidopsis  EC 1.1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant Physiol 2008 Sep;148(1):383-401
CBR3 protein, human  EC 1.1.1.184   *Alcohol Oxidoreductases. Mol Cell Biochem 2008 Aug;315(1-2):113-21
CBR1 protein, human  EC 1.1.1.184   *Alcohol Oxidoreductases. Mol Cell Biochem 2008 Aug;315(1-2):113-21
perakine reductase, Rauvolfia serpentina  EC 1.1.1.-   *Alcohol Oxidoreductases. Plant Mol Biol 2008 Jul;67(5):455-67
geraniol dehydrogenase, Carpoglyphus lactis  EC 1.1.1.1   *Alcohol Oxidoreductases. FEBS J 2008 Jun;275(11):2807-17
retinol dehydrogenase 13, human  EC 1.1.1.105   *Alcohol Oxidoreductases. FEBS J 2008 Jan;275(1):138-47
Rdh8 protein, mouse  EC 1.1.1.105   *Alcohol Oxidoreductases. Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19565-70
LET-767 protein, C elegans  EC 1.1.1.-   *Alcohol Oxidoreductases *Caenorhabditis elegans Proteins. Mol Genet Genomics 2003 Nov;270(2):121-31
GDH protein, Arabidopsis  EC 1.1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. J Exp Bot 2007;58(10):2709-15
BEN1 protein, Arabidopsis  EC 1.1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant J 2007 Jul;51(2):220-33
4-N-trimethylamino-1-butanol dehydrogenase, Pseudomonas  EC 1.1.1.-   *Alcohol Oxidoreductases *Bacterial Proteins. Biosci Biotechnol Biochem 2007 Jun;71(6):1439-46
HCR2 protein, human  EC 1.1.-   *Alcohol Oxidoreductases. Cell Mol Biol Lett 2006;11(2):230-11
CAD4 protein, Arabidopsis  EC 1.1.1.195   *Alcohol Oxidoreductases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2004 Feb 10;101(6):1455-60
CAD5 protein, Arabidopsis  EC 1.1.1.195   *Alcohol Oxidoreductases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2004 Feb 10;101(6):1455-60
MUM4 protein, Arabidopsis  0   *Multienzyme Complexes *Arabidopsis Proteins Alcohol Oxidoreductases Carbohydrate Epimerases Hydro-Lyases. J Biol Chem 2007 Feb 23;282(8):5389-403
alditol oxidase (FAD), Streptomyces coelicolor  EC 1.1.99.-   *Alcohol Oxidoreductases. Acta Crystallograph Sect F Struct Biol Cryst Commun 2006 Dec 1;62(Pt 12):1298-300
SAG13 protein, Arabidopsis  EC 1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant Biol (Stuttg) 2006 Sep;8(5):579-86
dehydroquinate dehydratase-skikimate dehydrogenase, Arabidopsis  0   *Alcohol Oxidoreductases *Hydro-Lyases. Biochemistry 2006 Jun 27;45(25):7787-96
DkgA protein, E coli  EC 1.1.1.184   *Alcohol Oxidoreductases *Escherichia coli Proteins. Proteins 2006 Jan 1;62(1):302-7
L2HGDH protein, human  EC 1.1.99.2   *Alcohol Oxidoreductases Mitochondrial Proteins. Hum Mol Genet 2004 Nov 15;13(22):2803-11
AKR11C1 protein, Bacillus halodurans  EC 1.1.1.184   *Alcohol Oxidoreductases. J Mol Biol. 2005 Nov 25;354(2):304-16
isethionate dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. Arch Microbiol 2005 Aug;183(5):325-30
Cyp2d1 protein, rat  EC 1.14.14.1   *Alcohol Oxidoreductases.
Rdh11 protein, zebrafish  EC 1.1.1.105   *Alcohol Oxidoreductases *Zebrafish Proteins. J Biol Chem 2005 Aug 26;280(34):30490-5
phthiodiolone ketoreductase  EC 1.1.-   *Alcohol Oxidoreductases. J Bacteriol 2005 Jul;187(14):4760-6
Hao2 protein, rat  EC 1.1.3.15   *Alcohol Oxidoreductases. Biochemistry 2005 Feb 8;44(5):1521-31
YDL124W protein, S cerevisiae  EC 1.1.1.-   *Alcohol Oxidoreductases *Saccharomyces cerevisiae Proteins. Biosci Biotechnol Biochem 2004 Nov;68(11):2306-12
FVT-1 protein, mouse  0   *Alcohol Oxidoreductases. J Biol Chem 2004 Nov 19;279(47):49243-50
gluconolactone oxidase  EC 1.1.3.-   *Alcohol Oxidoreductases. Appl Environ Microbiol 2004 Sep;70(9):5503-10
RDH12 protein, human  EC 1.1.1.105   *Alcohol Oxidoreductases. Nat Genet 2004 Aug;36(8):850-4
pyridoxine 4-oxidase  EC 1.1.3.12   *Alcohol Oxidoreductases. FEMS Microbiol Lett 2004 May 15;234(2):225-30
sniffer protein, Drosophila  EC 1.1. -   *Alcohol Oxidoreductases *Drosophila Proteins. Curr Biol. 2004 May 4;14(9):782-6
D-galacturonic acid reductase  EC 1.1.1.-   *Alcohol Oxidoreductases. Nat Biotechnol 2003 Feb;21(2):177-81
salicyl alcohol oxidase  EC 1.1.3.7   *Alcohol Oxidoreductases. Insect Biochem Mol Biol 2002 Nov;32(11):1517-23
dihydroxyacetamido dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. Bioorg Med Chem 1002 May;1095):1221-7
Ilv5 protein, S cerevisiae  EC 1.1.1.86   *Alcohol Oxidoreductases *Mitochondrial Proteins. J Biol Chem 2002 Dec 6;277(49):47946-53
pancreas protein 2, human  EC 1.1.1.71   *Alcohol Oxidoreductases. FEBS Lett 2002 Nov 20;531(3):489-93
ABA2 protein, Arabidopsis  EC 1.1.-   *Alcohol Oxidoreductases *Arabidopsis Proteins. Plant Cell 2002 Aug;14(8):1833-46
YfcX protein, E coli  0   *Multienzyme Complexes *Escherichia coli Proteins Alcohol Oxidoreductases Enoyl-CoA Hydratase. J Bacteriol 2002 Oct;184(20):5696-705
YPR1protein, S cerevisiae  EC 1.1.1.-   *Alcohol Oxidoreductases *Saccharomyces cerevisiae Proteins. Yeast 2002 Sep 15;19(12):1087-96
citral dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. Appl Microbiol Biotechnol 2001 Dec;57(5-6):731-7
citrol dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. Appl Microbiol Biotechnol 2001 Dec;57(5-6):731-7
Rv2002 protein, Mycobacterium tuberculosis  EC 1.1.1.100   *Alcohol Oxidoreductases *Bacterial Proteins. Acta Crystallogr D Biol Crystallogr 2002 Feb;58( Pt 2):303-5
2-hydroxypropylthioethanesulfonate dehydrogenase, Xanthobacter  EC 1.1.1.-   *Alcohol Oxidoreductases. Biochemistry 2002 Feb 26;41(8):2727-40
3beta-brassinosteroid dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. Phytochemistry 2001 Dec;58(7):989-94
benzil reductase  EC 1.1.1.-   *Alcohol Oxidoreductases. Biotechnol Bioeng 2001 Dec 20;75(6):630-3
tetrahydrofurfuryl alcohol dehydrogenase  EC 1.1.1.-   *Alcohol Oxidoreductases. J Bacteriol 2001 Dec;183(24):7408-11
NDP-4-keto-rhamnose 4'-ketoreductase  EC 1.1.1.-   *Alcohol Oxidoreductases *Bacterial Proteins. J Bacteriol 2001 Oct;183(19):5632-8
sinapyl alcohol dehydrogenase  0   *Alcohol Oxidoreductases. Plant Cell 2001 Jul;13(7):1567-86
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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