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Aldehyde Dehydrogenase

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Definition: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.     
Examples omega-Crystallins 		Other names D-Glucuronolactone Dehydrogenase; Dehydrogenase, D-Glucuronolactone; Dehydrogenase, Aldehyde; D Glucuronolactone Dehydrogenase; Aldehyde NAD Oxidoreductase; Aldehyde-NAD Oxidoreductase; Aldehyde Dehydrogenase E2; Aldehyde Dehydrogenase E1; Aldehyde Dehydrogenase (NAD(+))
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALDH3-1 protein, soybean  EC 1.1.1.70   *Soybean Proteins *Aldehyde Dehydrogenase. Yi Chuan. 2010 May;32(5); 492-7
ALDH16A1 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase. Neurogenetics. 2009 Jul;10(3):217-28
ALDH1L1 protein, human  EC 1.5.1.6   *Aldehyde Dehydrogenase. J Neuropathol Exp Neurol 2008 Dec;67(12):1194-204
ALDH1B1 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase. Stem Cells 2007 Oct;25(10):2628-37
ALDH7B4 protein, Arabidopsis  EC 1.2.1.3   *Aldehyde Dehydrogenase *Arabidopsis Proteins. Plant Mol Biol 2005 Feb;57(3):315-32
ALDH3I1 protein, Arabidopsis  EC 1.2.1.3   *Aldehyde Dehydrogenase *Arabidopsis Proteins. Plant Mol Biol 2005 Feb;57(3):315-32
aldehyde dehydrogenase 2, mouse  EC 1.2.1.3   *Aldehyde Dehydrogenase. Alcohol Clin Exp Res 2006 Oct;30(10):1659-69
aldehyde dehydrogenase 1A1, mouse  EC 1.2.1.3   *Aldehyde Dehydrogenase. Alcohol Clin Exp Res 2006 Oct;30(10):1659-69
gamma-trimethylaminobutyraldehyde dehydrogenase, mouse  EC 1.2.1.3   *Aldehyde Dehydrogenase. Anal Biochem. 2006 Jul 1;354(1):132-9
Aldh1a2 protein, mouse  EC 1.14.13.-   *Aldehyde Dehydrogenase. J Cell Biol 2006 Jul 3;174(1):101-13
ALDH1A1 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase. Acta Pol Pharm 2005 Nov-Dec;62(6):427-33
nicotinoprotein aldehyde dehydrogenase, Sphingomonas macrogoltabidus  EC 1.2.1.-   *Aldehyde Dehydrogenase. Appl Microbiol Biotechnol 2005 Sep;68(5):639-46
Aldh2 protein, rat  EC 1.2.1.3   *Aldehyde Dehydrogenase *Mitochondrial Proteins. Pharmacogenetics 2003 Aug;13(8):509-15
AASDH protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase *Neoplasm Proteins. Mol Biol Rep. 2005 Mar;32(1):47-53
aspartyl semialdehyde dehydrogenase, Helicobacter pylori  EC 1.2.1.3   *Aldehyde Dehydrogenase *Bacterial Proteins. J Nat Prod 2005 May;68(5):804-6
8S benzo(a)pyrene-binding protein, mouse  0   *Aldehyde Dehydrogenase *Carrier Proteins.
4S benzo(a)pyrene-binding protein, rat  EC 1.2.1.-   *Aldehyde Dehydrogenase *Carrier Proteins.
reduced epidermal fluorescence1 protein, Arabidopsis  EC 1.2.1.3.   *Aldehyde Dehydrogenase. Plant Cell 2004 Feb;16(2);544-54
Aldh7a1 protein, mouse  EC 1.2.1.3   *Aldehyde Dehydrogenase.
DNR-BP54 protein, mouse  EC 1.2.1.-   *Aldehyde Dehydrogenase.
ALDH3A1 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase Eye Proteins. Biochem J 2003 Dec 15;376(Pt 3):615-23
zRalDH protein, Taeniopygia guttata  EC 1.2.1.-   *Aldehyde Dehydrogenase *Nerve Tissue Proteins. Neuron. 2000 Aug;27(2)
N-(ethoxycarbonyl)-O-(diethylcarbamoyl)benzenesulfohydroxamic acid  0   *Hydroxamic Acids *Sulfonamides Aldehyde Dehydrogenase/antagonists & inhibitors. J Med Chem 1999 Oct 7;42(20):4016-20
N-(N,N-diethylcarbamoyl)-O-methylbenzenesulfohydroxamic acid  0   *Hydroxamic Acids *Sulfonamides Aldehyde Dehydrogenase/antagonists & inhibitors. J Med Chem 1999 Oct 7;42(20):4016-20
resorufin dimethylcarbamate  0   *Carbamates *Oxazines Aldehyde Dehydrogenase. Adv Exp Med Biol 1999;463:89-96
NPI 2  0   *Carbamates *Sulfonamides Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1998 Feb 15;55(4):465-74
API 2  0   Chlorpropamide/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1998 Feb 15;55(4):465-74
S-isobutylisothiourea  44744-73-2   Thiourea/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1870-5
S-n-butylisothiourea  2986-22-3   Thiourea/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1870-5
Aldh3a1protein, mouse  EC 1.2.1.3   *Aldehyde Dehydrogenase. Adv Exp Med Biol 1997;414:37-46
indole-3-acetaldehyde dehydrogenase, Ustilago maydis  EC 1.2.1.-   *Aldehyde Dehydrogenase *Fungal Proteins. Eur J Biochem 1996 Dec 15;242(3):648-56
4-sulfobenzaldehyde dehydrogenase  EC 1.2.1.-   *Aldehyde Dehydrogenase. J Bacteriol 1997 Feb;179(3):919-27
GbsA protein, Bacillus subtilis  EC 1.2.1.-   *Aldehyde Dehydrogenase *Bacterial Proteins. J Bacteriol 1996 Sep;178(17):5121-9
ALDH2 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase. Adv Exp Med Biol 1995;372:131-6
FIS1 protein, Linum usitatissimum  EC 1.2.1.3   *Plant Proteins Aldehyde Dehydrogenase. Plant J 1995 Jul;8(1):1-8
4-(N,N-dipropylamino)benzaldehyde  613-28-5   *Benzaldehydes Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1995 Jul 31;50(3):399-406
btg-26 protein, Brassica napus  EC 1.1.1.-   *Plant Proteins Aldehyde Dehydrogenase. Plant Mol Biol 1995 Feb;27(3):541-51
ALDH7A1 protein, human  EC 1.2.1.3   *Aldehyde Dehydrogenase. Genomics 1994 May 15;21(2):371-8
S-methyl-N,N-diethylthiolcarbamate sulfone  0   Ditiocarb/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1994 Apr 20;47(8):1465-7
S-methyl N,N-diethylthiolcarbamate sulfoxide  140703-15-7   Ditiocarb/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1992 Feb 4;43(3):403-6
azoxy procarbazine oxidase  EC 1.2.1.-   *Aldehyde Dehydrogenase. Drug Metab Dispos 1991;19(4):795
dioxiram  59547-11-4 Thioperoxydicarbonic diamide (((H2N)C(O))2S2), tetraethyl  *Carbamates *Disulfides Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem J 1991;278(Pt 1):189
S-methyl diethylthiocarbamate  37174-63-3   *Thiocarbamates Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem J 1991;278(Pt 1):189
1-methyl-5-(methyldithio)-1H-tetrazole  101554-56-7   *Tetrazoles Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem J 1989;261(1):281
4-amino-4-methyl-2-pentyne-1-al  121188-32-7   *Aldehydes Aldehyde Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1989;38(8):1335
phenethyl isothiocyanate  2257-09-2   *Isothiocyanates Aldehyde Dehydrogenase/antagonists & inhibitors.
Pharma Action Carcinogens ; Enzyme Inhibitors ; Anticarcinogenic Agents 		Cancer Res 1989;49(3):549
N(1)-ethylchlorpropamide  117048-15-4   Chlorpropamide/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. Alcoholism (NY) 1988;12(4):563
thyroid hormone-binding proteins  0   *Carrier Proteins *Membrane Proteins *Thyroid Hormones Aldehyde Dehydrogenase Neoplasm Proteins Triiodothyronine Xenopus Proteins. J Histochem Cytochem 1987;35(10):1043
5,5'-dithiobis(1-methyltetrazole)  62671-38-9   *Tetrazoles Alcohol Oxidoreductases/antagonists & inhibitors Aldehyde Dehydrogenase/antagonists & inhibitors Mixed Function Oxygenases. Alcoholism 1986;10(1):27
diethyldithiocarbamic acid methanethiol  22158-12-9 Carbamo(dithioperoxo)thioic acid, diethyl-, (S)  Ditiocarb/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors. FEBS Lett 1985;179(1):77
daunorubicin-binding protein, rat  EC 1.2.1.-   *Aldehyde Dehydrogenase *Carrier Proteins Daunorubicin. Mol Pharmacol 1983;24(2):336
corneal protein 54, bovine  0   *Aldehyde Dehydrogenase Eye Proteins Isoenzymes.
Pharma Action Antioxidants 		Exp Eye Res 1981;32(2):205
methyl diethyldithiocarbamate  686-07-7   Ditiocarb/*analogs & derivatives Aldehyde Dehydrogenase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Aviat Space Environ Med 49(5):665;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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