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Aldehyde-Lyases

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Definition: Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.     
Examples Fructose-Bisphosphate Aldolase 		Other names Aldehyde Lyases; Aldolases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cytochrome CYP74B1, flax  EC 4.1.2.-   *Aldehyde-Lyases *Cytochrome P-450 Enzyme System. Dokl Biochem Biophys. 2011 Sep-Oct;440():221-4
At1g27980 protein, Arabidopsis  EC 4.1.2.-   *Aldehyde-Lyases *Arabidopsis Proteins. J Biol Chem 2007 Sep 21;282(38):28195-206
THA2 protein, Arabidopsis  EC 4.1.2.5   *Aldehyde-Lyases *Arabidopsis Proteins. Plant Cell 2006 Dec;18(12):3564-75
THA1 protein, Arabidopsis  EC 4.1.2.5   *Aldehyde-Lyases *Arabidopsis Proteins. Plant Cell 2006 Dec;18(12):3564-75
ALL protein, Arabidopsis  EC 4.1.2.-   *Aldehyde-Lyases *Arabidopsis Proteins. Mol Cells 2005 Jun 30;19(3):342-9
HpaI protein, E coli  EC 4.1.2.-   *Aldehyde-Lyases *Escherichia coli Proteins. Biochemistry 2005 Jul 12;44(27):9447-55
Fol1 protein, S cerevisiae  0   *Aldehyde-Lyases *Dihydropteroate Synthase *Multienzyme Complexes *Diphosphotransferases. Mol Biol Cell 2004 Aug;15(8):3811-28
S-hydroxynitrile lyase, Hevea brasiliensis  EC 4.1.2.37   *Aldehyde-Lyases Plant Proteins. J Biotechnol 2004 Jul 1;111(1):31-9
4-carboxy-4-hydroxy-2-oxoadipate aldolase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 2003 Jan;185(1):41-50
fsaA protein, E coli  EC 4.1.2.-   *Aldehyde-Lyases *Escherichia coli Proteins. J Biol Chem. 2001 Apr 6;276(14):11055-61; J Mol Biol. 2002 May 24;319(1):161-71
2-dehydro-3-deoxygalactarate aldolase  EC 4.1.2.20   *Aldehyde-Lyases. EMBO J 2000 Aug 1;19(15):3849-56
cyclic bisphosphate  0   *Organophosphorus Compounds Aldehyde-Lyases/antagonists & inhibitors. Biochemistry 1998 Nov 17;37(46):16390-9
4-hydroxy-2-ketopentanoic acid aldolase  EC 4.1.2.-   *Aldehyde-Lyases. Appl Environ Microbiol 1998 Oct;9(10):4093-4
2'-carboxybenzalpyruvate hydratase-aldolase  EC 4.-   *Aldehyde-Lyases *Hydro-Lyases *Multienzyme Complexes Bacterial Proteins. J Bacteriol 1998 Feb;180(4):945-9
threonine acetaldehyde-lyase  EC 4.1.2.5   *Aldehyde-Lyases. Eur J Biochem 1997 Sep 1;248(2):385-93
phospho-2-keto-3-deoxy-gluconate aldolase  EC 4.1.2.14   *Aldehyde-Lyases.
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, E coli  EC 4.1.2.-   *Aldehyde-Lyases *Escherichia coli Proteins. Gene 1995 Dec 1;166(1):73-6
2-keto-3-deoxy-D-galactonate aldolase  EC 4.1.2.-   *Aldehyde-Lyases. Antonie Van Leeuwenhoek 1995;67(2):211-6
acetone-cyanohydrin lyase  EC 4.1.2.37   *Aldehyde-Lyases. Arch Biochem Biophys 1994 Jun;311(2):496-502
GLY1 protein, S cerevisiae  EC 4.1.2.5   *Aldehyde-Lyases *Saccharomyces cerevisiae Proteins. J Biol Chem 1994 Mar 25;269(12):9155-65
tetracenomycin F2 cyclase, Streptomyces  EC 4.1.2.-   *Aldehyde-Lyases *Bacterial Proteins. Biochemistry 1993 Oct 19;32(41):11149-54
hydroxymandelonitrile lyase  EC 4.1.2.11   *Aldehyde-Lyases. J Chromatogr 1992 Dec 11;584(1):85-92
fructose-6-phosphate phosphoketolase  EC 4.1.2.22   *Aldehyde-Lyases. J Appl Bacteriol 1990;68(6):619
benzaldehyde lyase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 1989;171(5):2401
hydroperoxide lyase  EC 4.1.2.-   *Aldehyde-Lyases *Cytochrome P-450 Enzyme System. Biochem Biophys Res Commun 1987;149(3):1111
alpha-pinene oxide lyase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 1987;169(11):4972
3,4-dihydroxyphenylserine aldolase  EC 4.1.2.-   *Aldehyde-Lyases. Biochem Biophys Res Commun 1987;143(2):482
fucosterol epoxide lyase  EC 4.1.2.-   *Aldehyde-Lyases. Anal Biochem 1985;151(2):315
aldehyde decarbonylase  EC 4.1.2.-   *Aldehyde-Lyases. Proc Natl Acad Sci USA 1984;81(21):6613
4-oxalcitramalate aldolase  EC 4.1.3.-   *Aldehyde-Lyases. J Biochem (Tokyo) 1983;93(2):567
L-fuculosephosphate aldolase  EC 4.1.2.17   *Aldehyde-Lyases. J Bacteriol 1982;152(1):120
beta-hydroxy-trimethyllysine aldolase  EC 4.1.2.-   *Aldehyde-Lyases. Biochim Biophys Acta 1980;630(1):22
2'-hydroxybenzalpyruvate aldolase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 1980;141(3):1052
trimethylamine-oxide aldolase  EC 4.1.2.32   *Aldehyde-Lyases. Biochem J 148:513;1975
tagatose 1,6-diphosphate aldolase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 140(3):1102;1979
sphingosine 1-phosphate lyase (aldolase)  EC 4.1.2.-   *Aldehyde-Lyases. Chem Phys Lipids 13(4):382;1974
rhamnulose-1-phosphate adolase  EC 4.1.2.19   *Aldehyde-Lyases.
phosphoketolase  EC 4.1.2.9   *Aldehyde-Lyases. J Gen Microbiol 102(2):392;1977
6-phospho-2-keto-3-deoxy-galactonate aldolase  EC 4.1.2.21 2-keto-3-deoxygalactonate 6-P aldolase  *Aldehyde-Lyases. J Biol Chem 250(17):6875;1975
neuraminic acid aldolase  EC 4.1.2.-   *Aldehyde-Lyases. Gig Sanit 9:19;1978
mandelonitrile lyase  EC 4.1.2.10   *Aldehyde-Lyases. FEBS Lett 90(2):255;1978; J Biol Chem 254(23):12145;1979
2-keto-3-deoxy-L-pentonate aldolase  EC 4.1.2.18 2-keto-3-deoxy-L-arabonate aldolase  *Aldehyde-Lyases. Biochem Biophys Res Commun 36(5):809;1969; Methods Enzymol 42C:269;1975
2-keto-3-deoxygluconate aldolase  EC 4.1.2.-   *Aldehyde-Lyases. J Bacteriol 124(3):1128;1975
2-keto-3-deoxy-D-glucarate aldolase  EC 4.1.2.20   *Aldehyde-Lyases.
hexose phosphate synthetase  EC 4.1.2.-   *Aldehyde-Lyases. Appl Environ Microbiol 36(1):56;1978; Biochem J 116(4):631;1970; Biochem J 139(1):129;1974; Biochem J 144(3):477;1974; Biochim Biophys Acta 523:236;1978; Biokhimiia 43(5):782;1978; Eur J Biochem 66:591;1976; J Bacteriol 124(2):1028;1975; Mikrobiologiia 45(3):417;1976; Mikrobiologiia 46(1):46;1977; Z Allg Microbiol 17(3):175;1977; Z Allg Mikrobiol 18(9):261;1978; Z Allg Mikrobiol 18(9):691;1978
dihydroneopterin aldolase  EC 4.1.2.25   *Aldehyde-Lyases. Adv Enzymol 35(0):35;1971
deoxyribose-phosphate aldolase  EC 4.1.2.4   *Aldehyde-Lyases. Anal Biochem 87(1):56;1978; Arch Biochem Biophys 177:630;1976; Biochem J 157(3):573;1976; J Mol Biol 1979;133(1):1; Molec Gen Genet 137:289;1975
2-dehydro-3-deoxyphosphooctonate aldolase  EC 4.1.2.16   *Aldehyde-Lyases Arabidopsis Proteins. Eur J Biochem 76:41;1977; J Biol Chem 252(14):4895;1977; J Biol Chem 252(14):4904;1977; Proc Natl Acad Sci USA 69(12):3756;1972

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