encyclopedia of medical concepts
ψ 

Aldehyde Reductase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.      Other names Aldose Reductase; Reductase, Xylose; Reductase, Erythrose; Reductase, Aldose; Reductase, Aldehyde; Reductase Ib, Aldose; Reductase Ia, Aldose; Xylose Reductase; Erythrose Reductase; Aldose Reductase Ib; Aldose Reductase Ia
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(3beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid  0   *Triterpenes Aldehyde Reductase/antagonists & inhibitors. Bioorg Khim. 2011 Sep-Oct;37(5):637-44
glucodistylin  0   *Glycosides *Flavonols Aldehyde Reductase/antagonists & inhibitors. Arch Pharm Res. 2011 Feb;34(2):181-9
IDD 393  0   *Benzene Derivatives Aldehyde Reductase/antagonists & inhibitors. Biochim Biophys Acta. 2011 Sep;1810(9):879-87
Akr1b7 protein, rat  EC 1.1.1.-   *Aldehyde Reductase. Biol Pharm Bull. 2010;33(11):1886-90
ganoderic acid C2  0   *Triterpenes Aldehyde Reductase/antagonists & inhibitors. Planta Med. 2010 Oct;76(15):1691-3
semilicoisoflavone B  0   *Flavonoids Aldehyde Reductase/antagonists & inhibitors. Biol Pharm Bull 2010;33(5):917-21
2-(3,4-dihydroxyphenyl)-6-hydroxypyrido(1,2-a)pyrimidin-4-one  0   *Pyridines *Pyrimidinones Aldehyde Reductase/antagonists & inhibitors. J Pharm Pharmacol 2010 Jan;62(1):107-13
Akr1b10 protein, rat  EC 1.1.1.-   *Aldehyde Reductase. Arch Biochem Biophys. 2010 Nov 15;503(2); 230-7
(6-methyl-3-(4,5,7-trifluorobenzothiazol-2-ylmethyl)pyrrolo(2,3-b)pyridin-1-yl)acetic acid  0   *Benzothiazoles Aldehyde Reductase/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Apr 1;19(7):2006-8
N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido(3,4-b)indol-1-one  0   *Carbolines Aldehyde Reductase/antagonists & inhibitors. Yakugaku Zasshi 1967 May;87(5):608-10
Akr1b8 protein, rat  EC 1.1.1.-   *Aldehyde Reductase. Chem Biol Interact 2009 Mar 16;178(1-3):151-7
2-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)acetic acid  0   *Acetic Acids *Oxadiazoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2008 Jun 12;51(11):3182-93
YqhD protein, E coli  EC 1.1.1.21   *Aldehyde Reductase *Escherichia coli Proteins. J Biol Chem 2008 Mar 21;283(12):7346-53
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole-8-yl)-acetic acid  0   *Acetic Acids *Indoles Aldehyde Reductase/antagonists & inhibitors. Gen Physiol Biophys. 2006 Dec;25(4):415-25
furfural reductase, E coli  EC 1.1.1.21   *Aldehyde Reductase. J Biotechnol 2006 Jan 24;121(2):154-64
aldehyde reductase AKR1A4, mouse  EC 1.1.1.21   *Aldehyde Reductase. Toxicol Appl Pharmacol 2006 Jan 1;210(1-2):163-70
lidorestat  0   *Indoleacetic Acids *Thiazoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2005 May 5;48(9):3141-52
Idd 594  0   *Acetates *Thioamides Aldehyde Reductase/antagonists & inhibitors. Proteins 2004 Jun 1;55(4):792-804
(3-benzoylpyrrol-1-yl)acetic acid  0   *Acetic Acids *Pyrroles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2004 May 6;47(10):2706-9
(1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl)phenylmethanone  0   *Phenols *Pyrroles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2004 May 6;47(10):2706-9
AKR1B1 protein, human  EC 1.1.1.21   *Aldehyde Reductase.
4-oxo-4-(4-hydroxyindole)butanoic acid  0   *Butyric Acids *Indoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2003 Dec 18;46(26):5619-27
6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one  0   *Pyridazines *Sulfones Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2003 Jun 5;46(12):2283-6
asperaldin  0   *Naphthoquinones Aldehyde Reductase/antagonists & inhibitors. J Antibiot (Tokyo) 2003 Feb;56(2):173-6
cyano(5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-yl)acetic acid  0   *Indoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2003 Apr 10;46(8):1419-28
minalrestat  129688-50-2   *Imides *Quinolones Aldehyde Reductase/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Mar;304(3):1236-42
(2,4-bis(4-methoxybenzoyl)pyrrol-1-yl)acetic acid  0   *Acetic Acids *Pyrroles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2003 Jan 30;46(3):417-26
renal-specific oxidoreductase, mouse  EC 1.1.1.21   *Aldehyde Reductase. Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9896-901
YUA001  0   Tyramine/*analogs & derivatives Aldehyde Reductase. J Antibiot (Tokyo) 2001 Oct;54(10):827-30
(10-benzyl-(1,2,4)triazino(4,3-a)benzimidazol-3,4(10H)-dion-2-yl)acetic acid  0   *Benzimidazoles *Triazines Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2001 Dec 6;44(25):4359-69
AKR7A1  EC 1.1.1.-   *Aldehyde Reductase. Biochem Pharmacol 2001 Dec 1;62(11):1511-9
1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano(4,3-b)(1)benzopyran-3-acetic acid  0   *Acetic Acids *Benzopyrans Aldehyde Reductase/antagonists & inhibitors. Mol Vis 2001 Jul 18;7:164-71
succinic acid benzyl ester 3-carboxymethyl-1-(4-chlorobenzoyl)-2-methylindol-5-yl ester  0   *Indoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 2001 May 24;44(11):1718-28
androgen-inducible aldehyde reductase  EC 1.2.1.-   *Aldehyde Reductase. Endocrinology 2000 Sep;141(9):3194-9
IDD384  0   *Sulfones Aldehyde Reductase/antagonists & inhibitors. Acta Crystallogr D Biol Crystallogr 2000 May;56 ( Pt 5):536-40
kotalagenin 16-acetate  0   *Triterpenes Aldehyde Reductase/antagonists & inhibitors Glucosidases/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1999 Dec;47(12):1725-9
AKR1B10 protein, human  EC 1.1.1.-   *Aldehyde Reductase. Adv Exp Med Biol 1999;463:427-34; J Biol Chem 1998 May 8;273(19):11429-35
kikkanol C  0   *Sesquiterpenes Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
kikkanol B  0   *Sesquiterpenes Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
kikkanol A  0   *Sesquiterpenes Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
3-methyl-4-(4-chlorophenyl)isoxazolo(3,4-d)pyridazin-7(6H)-one acetic acid  0   *Isoxazoles *Pyridazines Aldehyde Reductase/antagonists & inhibitors. J Med Chem 1999 Jun 3;42(11):1894-900
spirofluorene-9,5'-imidazolidine-2',4'-dione  0   *Spiro Compounds *Imidazolidines Aldehyde Reductase/antagonists & inhibitors. Bioorg Med Chem 1998 Oct;6(10):1811-9
SX 3030  0   *Pyrazines *Spiro Compounds Aldehyde Reductase/antagonists & inhibitors Stereoisomerism. J Med Chem 1998 Oct 8;41(21):4118-29
salvianolic acid K  0   *Cinnamates *Phenylpropionates Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull 1998 Mar;46(3):500-4
lithospermic acid B  121521-90-2   *Benzofurans *Depsides Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull 1998 Mar;46(3):500-4
salviaflaside  178895-25-5   *Glucosides *Phenylpropionates Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull 1998 Mar;46(3):500-4
danshenol B  0   *Diterpenes Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Aug;45(8):1306-11
danshenol A  0   *Diterpenes Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Aug;45(8):1306-11
GP 1447  0   *Phenylacetates *Thiazoles Aldehyde Reductase/antagonists & inhibitors. Jpn J Pharmacol 1997 Feb;73(2):133-44
3-((5-chlorobenzothiazol-2-yl)methyl)-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-1-acetic acid  0   *Pyrimidinones *Thiazoles Aldehyde Reductase/antagonists & inhibitors. J Med Chem 1997 Feb 28;40(5):684-94
ONO 3  0   *Acetic Acids *Thiazoles Aldehyde Reductase/antagonists & inhibitors. Eur J Biochem 1997 Jan 15;243(1-2):274-82
ONO 1  0   *Furans *Thiazoles Aldehyde Reductase/antagonists & inhibitors. Eur J Biochem 1997 Jan 15;243(1-2):274-82
ICI 222155  132414-04-1   *Nitroparaffins *Sulfones Aldehyde Reductase/antagonists & inhibitors. Eur J Pharmacol 1995 Oct 16;285(2):189-97
35-kDa hypertonic stress protein, human  0   *Heat-Shock Proteins Aldehyde Reductase. Cell Biochem Funct 1995 Mar;13(1):1-8
WAY 121-509  0   Aldehyde Reductase/*antagonists & inhibitors. Diabetes Res Clin Pract 1994 Sep;25(2):117-29
matteuorienate B  161161-69-9 Pentanedioic acid, 3-hydroxy-3-methyl-, 6'-ester with 7-(beta-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-6,8-dimethyl-2-phenyl-4H-1-benzopyran-4-one  *Flavonoids Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1994 Aug;42(8):1712-4
matteuorienate A  161161-68-8 Pentanedioic acid, 3-hydroxy-3-methyl-, 6'-ester with 7-(beta-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-6,8-dimethyl-4H-1-benzopyran-4-one  *Flavonoids Aldehyde Reductase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1994 Aug;42(8):1712-4
ZENECA ZD 5522  0   *Acetanilides *Sulfones Aldehyde Reductase/antagonists & inhibitors. Diabetologia 1994 Jul;37(7):651-63
SPR 210  143162-65-6   *Thiazines *Benzothiazoles Aldehyde Reductase/antagonists & inhibitors. Jpn J Pharmacol 1994 Feb;64(2):115-24
aflatoxin B1 aldehyde reductase  EC 1.1.1.-   *Aldehyde Reductase. Cancer Res 1993 Sep 1;53(17):3887-94
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy