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Apomorphine

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Definition: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.  apomorphine derivatives   
Pharmacological Action Antiparkinson Agents; Dopamine Agonists 		Other names Hydrochloride, Hemihydrate Apomorphine; Hydrochloride, Anhydrous Apomorphine; Hemihydrate Apomorphine Hydrochloride; Chloride, Apomorphine; ApomorphinTeclapharm; Apomorphin Teclapharm; Anhydrous Apomorphine Hydrochloride; Teclapharm Brand of Apomorphine Hydrochloride; Britannia Brand of Apomorphine Hydrochloride; Britaject; Apomorphine Hydrochloride, Hemihydrate; Apomorphine Hydrochloride, Anhydrous; Apomorphine Chloride; Apomorphin-Teclapharm; Apokinon; Aguettant Brand of Apomorphine HydrochlorideDrugs* : APOKYN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-chloro-N-n-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Carbon Radioisotopes Ligands Receptors, Dopamine D2/agonists. Nucl Med Biol 2010 Jan;37(1):35-40
2,10,11-trihydroxy-N-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Receptors, Dopamine D2/agonists. Eur J Pain 2008 Jul;12(5):535-43
O,O'-diacetylapomorphine  0   Apomorphine/*analogs & derivatives. Biochem Biophys Res Commun 2008 May 9;369(3):824-9
8-oxo-apomorphine-semiquinone  0   *Quinones Apomorphine/*analogs & derivatives. Eur J Pharmacol 2002 May 17;443(1-3):105-111
10,11-dihydroxy-N-n-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Receptors, Dopamine D2/agonists. J Neurochem 2001 Apr;77(2):493-504
isothebaine  568-21-8   Apomorphine/*analogs & derivatives. Methods Find Exp Clin Pharmacol 1998 Nov;19(9):589-97
oxoglaucine  5574-24-3   Apomorphine/*analogs & derivatives. Methods Find Exp Clin Pharmacol 1998 Nov;19(9):579-83
2,10,11-trihydroxy-N-(n-3-fluoropropyl)norapomorphine  146578-67-8   Apomorphine/*analogs & derivatives. Appl Radiat Isot 1993 Apr;44(4):651-8
10,11-dihydroxy-N-(n-3-fluoropropyl)norapomorphine  146578-65-6   Apomorphine/*analogs & derivatives. Appl Radiat Isot 1993 Apr;44(4):651-8
10,11-dihydroxy-N-(n-2-fluoroethyl)norapomorphine  149156-25-2   Apomorphine/*analogs & derivatives. Appl Radiat Isot 1993 Apr;44(4):651-8
10,11-dihydroxy-N-methylnorapomorphine  147353-44-4   Apomorphine/*analogs & derivatives. Nucl Med Biol 1993 Jan;20(1):7-12
2-fluoro-N-n-propylnorapomorphine  130434-40-1   Apomorphine/*analogs & derivatives. J Med Chem 1990;33(12):3122
2-methoxy-N-n-propylnorapomorphine  126874-82-6   Apomorphine/*analogs & derivatives. J Med Chem 1990;33(6):1800
2-methoxyapomorphine  126874-79-1   Apomorphine/*analogs & derivatives. J Med Chem 1990;33(6):1800
2-fluoroapomorphine  119771-41-4   Apomorphine/*analogs & derivatives. J Med Chem 1989;32(6):1198
10,11-dimethoxy-N-n-propylnoraporphine  40285-10-7   Apomorphine/*analogs & derivatives. Biochem Biophys Res Commun 1985;127(2):407
N-n-propylnorisoapocodeine  96158-78-0 4H-Dibenzo(de,g)quinolin-10-ol, 5,6,6a,7-tetrahydro-11-methoxy-6-propyl-, (R)  Apomorphine/*analogs & derivatives. Biochem Biophys Res Commun 1985;127(2):407
isoapocodeine  36507-69-4   Apomorphine/*analogs & derivatives. Biochem Biophys Res Commun 1985;127(2):407
2-hydroxyapomorphine  64781-18-6   Apomorphine/*analogs & derivatives. J Med Chem 1982;25(8):990
10,11-methylenedioxy-N-propylnoraporphine  81264-57-5 6H-Benzo(de)-1,3-benzodioxolo(4,5-g)quinoline, 6a,7,8,9-tetrahydro-7-propyl-, (R)  Apomorphine/*analogs & derivatives. Eur J Pharmacol 1982;77(1):87
apomorphine receptor  0   *Receptors, Opioid *Receptors, Dopamine D2 Apomorphine. Life Sci 1981;29(2):121
dibutyrylapomorphine  42390-72-7 butanoic acid 5,6,6a,7-tetrahydro- 6-methyl-4H-dibenzo(de,g)quinoline-10,11- diyl ester  Apomorphine/*analogs & derivatives. Endocrinology 102(3):837;1978
11,12-dihydroxy-7-methyl-4,5,6,7,7a,8-hexahydrophenanthro(10,1-b,c)azepine  57689-17-5   Apomorphine/*analogs & derivatives. Experientia 31(11):1327;1975
N-n-propylnorapomorphine  58479-52-0   Apomorphine/*analogs & derivatives Carbon Radioisotopes Radioactive Tracers Receptors, Dopamine D2/agonists.
Pharma Action Antiparkinson Agents ; Dopamine Agonists 		Arch Int Pharmacodyn Ther 1979;242(2):241; Arch Neurol 35(12):787;1978; Exp Neurol 55(1):56;1977; Experientia 34(11):1490;1978; J Med Chem 16(11):1223;1973; Lancet 1(7963):786;1976; N Engl J Med 294(11):567;1976; Nature 259(5544):584;1976; Pharmacol Biochem Behav 1979;11(6):653
norapomorphine  478-76-2   Apomorphine/*analogs & derivatives. J Chromatogr 87(1):294;1973; J Pharm Sci 63(1):161;1974
isoapomorphine  34029-43-1 5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo(de,g)quinoline-9,10-diol  Apomorphine/*analogs & derivatives. J Med Chem 16(11):1228;1973
apocodeine  641-36-1   Apomorphine/*analogs & derivatives. Exp Neurol 55(1):56;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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