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Lysine Carboxypeptidase

More information in Books or onNLM PubMed
Definition: A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with preference shown for lysine over arginine. It is a plasma zinc enzyme that inactivates bradykinin and anaphylatoxins.      Other names Kininase I; Carboxypeptidase N; Inactivator, Anaphylatoxin; Carboxypeptidase, Lysine; Bradykininase; Anaphylatoxin Inactivator
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
histargin  93361-66-1 L-Histidine, N-(2-((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)ethyl)-, (S)  *Guanidines *Imidazoles Lysine Carboxypeptidase/antagonists & inhibitors. J Antibiot (Tokyo) 1984;37(9):984
2-mercaptomethyl-3-guanidinoethylthiopropionic acid  77102-28-4 Propanoic acid, 3-((2-((aminoiminomethyl)amino)ethyl)thio)-2-(mercaptomethyl)-, (+-)  3-Mercaptopropionic Acid/*analogs & derivatives Lysine Carboxypeptidase/antagonists & inhibitors.
Pharma Action Protease Inhibitors 		Biochem Biophys Res Commun 1981;98(2):448
2-mercaptomethyl-5-guanidinopentanoic acid  69734-02-7   3-Mercaptopropionic Acid/*analogs & derivatives Lysine Carboxypeptidase/antagonists & inhibitors Carboxypeptidases/antagonists & inhibitors. Biochemistry 18(8):1427;1979
Clostridium kininase  EC 3.4.12.-   *Lysine Carboxypeptidase. Zentrlbl Bakt Hyg (Org A) 233(2):253;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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