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Arylsulfatases

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Definition: Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.     
Examples N-Acetylgalactosamine-4-Sulfatase; Cerebroside-Sulfatase; Steryl-Sulfatase 		Other names Arylsulfate Sulfohydrolases; Pseudo Arylsulfatase A; Arylsulphatases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ARSK protein, human  EC 3.1.6.1   *Arylsulfatases. Hum Mol Genet 2005 Nov 1;14(21):3203-17
ARSJ protein, human  EC 3.1.6.1   *Arylsulfatases. Gene 2006 May 10;372:110-7
ARSI protein, human  EC 3.1.6.1   *Arylsulfatases. Hum Mol Genet 2005 Nov 1;14(21):3203-17
arylsulfatase G, human  EC 3.1.6.-   *Arylsulfatases. Eur J Hum Genet. 2002 Dec;10(12):813-8
AtsA protein, Klebsiella pneumoniae  0   *Arylsulfatases. J Bacteriol 1990 Apr;172(4):2131-40
cholesterol sulfate sulfohydrolase  EC 3.1.6.-   *Arylsulfatases. J Steroid Biochem Mol Biol 2002 Jul;81(3):263-71
ARSE protein, human  EC 3.1.6.-   *Arylsulfatases. Cell 1995 Apr 7;81(1):15-25
bile acid 3alpha-sulfate sulfohydrolase  EC 3.1.6.-   *Arylsulfatases. Dig Dis Sci 1996 Aug;41(8):1564-70
pregnenolone-3-O-methylthiophosphonate  155538-87-7   Pregnenolone/*analogs & derivatives Arylsulfatases/antagonists & inhibitors. J Steroid Biochem Mol Biol 1994 Apr;48(5-6):523-7
2-hydroxydopamine  4228-71-1 1,2,3-Benzenetriol, 4-(2-aminoethyl)  *Hydroxydopamines Arylsulfatases/antagonists & inhibitors Neurotoxins. Ann N Y Acad Sci 1992 May 11;648:256-9
methylumbelliferone sulfatase  EC 3.1.6.-   *Arylsulfatases. New Zealand Med J 85(587):369;1977
L-ascorbate-2-sulfate sulfohydrolase  EC 3.1.6.-   *Arylsulfatases. Anal Biochem 79(1-2):23;1977; Biochem Biophys Res Comm 68(3):949;1976; J Biochem(Tokyo) 77(2):353;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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