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Asialoglycoproteins

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Definition: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.     
See Also Asialoglycoprotein Receptor 		Other names Glycoproteins, Desialylated; Desialylated Glycoproteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
asialoglycophorin AM  0   *Asialoglycoproteins. Org Lett 2005 Aug 4;7(16):3589-92
asialoerythropoietin  0   *Asialoglycoproteins Erythropoietin/*analogs & derivatives. J Neurochem 2004 Nov;91(4):900-10
Mgl1 protein, rat  0   *Membrane Proteins *Lectins, C-Type Asialoglycoproteins.
asialo-galactosyl-acetylgalactosamine  0   *Asialoglycoproteins Acetylgalactosamine/*analogs & derivatives. J Am Soc Nephrol 1996 Jun;7(6):955-60
asialoglycoprotein-polylysine conjugate  0   *Asialoglycoproteins Polylysine/*analogs & derivatives. Am J Med Sci 1994 Feb;307(2):138-43
asialofetuin 69-28 peptide  0   *alpha-Fetoproteins *Asialoglycoproteins *Peptide Fragments. Arch Oral Biol 1993 Nov;38(11):979-84
asialofetuin 21-45 peptide  0   *alpha-Fetoproteins *Asialoglycoproteins *Peptide Fragments. Arch Oral Biol 1993 Nov;38(11):979-84
asialofetuin 12 peptide  0   *alpha-Fetoproteins *Asialoglycoproteins *Peptide Fragments. Arch Oral Biol 1993 Nov;38(11):979-84
asialofibrin  0   *Asialoglycoproteins Fibrin/*analogs & derivatives. Biol Pharm Bull 1993 May;16(5):448-52
polyethylene glycol-asialofetuin complex  0   *alpha-Fetoproteins *Asialoglycoproteins *Polyethylene Glycols. J Biol Chem 1992 Nov 15;267(32):22987-93
asialoagalacto-human chorionic gonadotropin  0   *Asialoglycoproteins *Chorionic Gonadotropin. J Clin Invest 1991;88(6):1947
Mgl1 protein, mouse  0   *Asialoglycoproteins *Membrane Proteins *Lectins, C-Type. J Biol Chem 1990;265(19):11295; J Biol Chem 2002 Aug 9;277(32):28892-901
asialofetuin-polylysine-5'-uridine monophosphate conjugate  0   *alpha-Fetoproteins *Asialoglycoproteins Polylysine/*analogs & derivatives Uridine Monophosphate/*analogs & derivatives. Cancer Chemother Pharmacol 1990;26(2):93
asialogalactochoriongonadotropin  0   *Asialoglycoproteins *Chorionic Gonadotropin. Horm Metab Res 1990;22(3):196
asialoorosomucoid-polylysine conjugate  0   *Asialoglycoproteins Orosomucoid/*analogs & derivatives Polylysine/*analogs & derivatives DNA Drug Carriers. J Biol Chem 1988;263(29):14621
asialo-orosomucoid-horseradish peroxidase conjugate  0   *Asialoglycoproteins *Horseradish Peroxidase. Biochem J 1988;252(3):739
asialoorosomucoid-polylysine-UMP conjugate  0   *Asialoglycoproteins Orosomucoid/*analogs & derivatives Polylysine/*analogs & derivatives Uridine Monophosphate/*analogs & derivatives. J Biol Chem 1988;263(10):4719
asialohemopexin  0   *Asialoglycoproteins Hemopexin/*analogs & derivatives. Biochem J 1985;231(3):663
asialogalactoorosomucoid  0   *Asialoglycoproteins Orosomucoid/*analogs & derivatives. Biochemistry 1984;23(26):6437
asialo-von Willebrand Factor  0   *Asialoglycoproteins von Willebrand Factor/*analogs & derivatives. J Clin Invest 1985;75(1):19
Ep 459-asialofetuin conjugate  0   *alpha-Fetoproteins *Asialoglycoproteins Leucine/*analogs & derivatives. Exp Cell Res 1985;156(1):15
asialoagalactothyroglobulin  0   *Asialoglycoproteins *Thyroglobulin Autoantigens. Clin Exp Immunol 1984;56(1):129
asialoovomucoid  0   *Asialoglycoproteins Ovomucin. Carbohydr Res 1983;112(2):261
luteinizing hormone, desialylated  0   *Asialoglycoproteins Luteinizing Hormone/*analogs & derivatives. Biochim Biophys Acta 1982;720(2):193
asialofibrinogen  0   *Asialoglycoproteins *Fibrinogen. Biochim Biophys Acta 1981;677(3-4):381
asialo-Factor VIII  0   *Asialoglycoproteins Factor VIII. J Clin Invest 1981;68(2):321
asialohaptoglobin  0   *Asialoglycoproteins *Haptoglobins. C R Acad Sci (D) (Paris) 1981;292(17):983
asialo-carcinoembryonic antigen  0   *Asialoglycoproteins *Carcinoembryonic Antigen. Biochem J 1980;192(3):837
asialofetuin-DTPA complex  0   *alpha-Fetoproteins *Asialoglycoproteins Pentetic Acid/*analogs & derivatives. Health Phys 1981;40(2):228
asialoglycophorin  0   *Asialoglycoproteins. Biochim Biophys Acta 1979;587(3):373
asialoglycoprotein-binding protein, rat  0   *Receptors, Cell Surface *Lectins Asialoglycoproteins. Arch Physiol Biochim 1979;87(4):804; J Biol Chem 1980;255(7):3008
asialotranscortin  0 asialo-human transcortin  *Asialoglycoproteins Transcortin/*analogs & derivatives. Biochim Biophys Acta 585(4):543;1979
asialo-human chorionic gonadotropin  0   *Asialoglycoproteins *Chorionic Gonadotropin. J Endocrinol 80(2):46P;1979
asialothyroglobulin  0   *Asialoglycoproteins *Thyroglobulin. Biochim Biophys Acta 583(4):504;1979
asialotransferrins  0   *Asialoglycoproteins Transferrin/*analogs & derivatives. Biochem J 174(1):171;1978; Biochem J 1979;184(2):399; CR Acad Sci (D)(Paris) 288(5):523;1979; Int J Peptide Protein Res 12(1):27;1978
asialoorosomucoid  0   *Asialoglycoproteins Orosomucoid/*analogs & derivatives. Biochim Biophys Acta 541:372;1978; J Biol Chem 1980;255(7):3008; Life Sci 25(10):827;1979
asialofetuin  0   *Asialoglycoproteins *Fetuins. Acta Biol Med Ger 36(11-12):1753;1977; BBA 541:372;1978
asialoceruloplasmin  0   *Asialoglycoproteins Ceruloplasmin/*analogs & derivatives. Biochem J 174(1):309;1978; Exp Cell Res 117(1):165;1978; Gastroenterology 64(5):1049;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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