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Aspirin

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Definition: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)     
Pharmacological Action Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Platelet Aggregation Inhibitors 		Other names Acetylsalicylic Acid; Acid, Acetylsalicylic; Zorprin; Solupsan; Solprin; Polopiryna; Polopirin; Micristin; Magnecyl; Endosprin; Ecotrin; Easprin; Dispril; Colfarit; Aloxiprimum; Acylpyrin; Acetysal; 2-(Acetyloxy)benzoic AcidDrugs* : AZDONE; 8-HOUR BAYER; MEASURIN; AXOTAL; BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAIN; VICOPRIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate  0   *Disulfides *Nitrates Aspirin/*analogs & derivatives. Biochem Biophys Res Commun. 2012 Mar 16;419(3):523-8.
4-(5-thioxo-5H-1,2-dithiol-3-yl)-phenyl 2-acetoxybenzoate  0   *Thiones Aspirin/*analogs & derivatives. Biochem Pharmacol. 2012 Mar 15;83(6):715-22.
aspirin-phosphatidylcholine  0   *Aspirin *Phosphatidylcholines. Am J Gastroenterol. 2011 Feb;106(2):272-7
O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate  0   *Hydrazines Aspirin/*analogs & derivatives. J Pharmacol Exp Ther 2010 Nov;335(2):443-50
isosorbide-2-aspirinate-5-(3-nitrooxymethyl)benzoate  0   *Nitrates Aspirin/*analogs & derivatives. J Med Chem 2009 Nov 12;52(21):6588-98
isosorbide-2-aspirinate-5-(2-nitroxymethyl)benzoate  0   *Nitrates Aspirin/*analogs & derivatives. J Med Chem 2009 Nov 12;52(21):6588-98
isosorbide-2,5-diaspirinate  0   Aspirin/*analogs & derivatives Isosorbide/*analogs & derivatives. J Med Chem 2008 Dec 25;51(24):7991-9
phosphoaspirin  0   *Phosphoric Acid Esters Aspirin/*analogs & derivatives. Int J Oncol 2008 Jan;32(1):97-100
N-acetyl-2-carboxymethylbenzenesulfonamide  0   *Sulfonamides Aspirin/*analogs & derivatives. Bioorg Med Chem. 2005 Aug 1;13(15):4694-703
NCX 4050  0   *Nitro Compounds Aspirin/*analogs & derivatives. Circulation 2004 Aug 31;110(9):1140-7
NCX 4040  0   *Nitro Compounds Aspirin/*analogs & derivatives. Circulation 2004 Aug 31;110(9):1140-7
N-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester  0   *Nitrates Aspirin/*analogs & derivatives. J Urol 2004 Jul;172(1):338-44
isosorbide diaspirinate  0   Aspirin/*analogs & derivatives Isosorbide/*analogs & derivatives. Eur J Pharm Sci 2002 Sep;16(4-5):297-304
aspirin, succinic acid drug combination  0   *Aspirin *Succinic Acid Drug Combinations. Bull Exp Biol Med 2002 Jan;133(1):48-50
ethyl-2-acetoxyethylbenzoate  0   *Benzoates Aspirin/*analogs & derivatives Acetylation. Neurobiol Dis 2001 Oct;8(5):774-83
2-acetoxymethylbenzoate  0   *Benzoates Aspirin/*analogs & derivatives Acetylation. Neurobiol Dis 2001 Oct;8(5):774-83
valcophen  0   *Aspirin *Caffeine *Phenobarbital Drug Combinations. Fiziol Zh 1998;44(5-6):102-5
bis(3,5-dibromosalicyl)sebacate-crosslinked hemoglobin  0   *Hemoglobins Aspirin/*analogs & derivatives. Am J Physiol 1998 Oct;275(4 Pt 2):H1313-H1321
acetaminophen, aspirin, caffeine drug combination  0   *Acetaminophen *Aspirin *Caffeine Drug Combinations.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		J Pharm Pharmacol 1997 Dec;49(12):1260EXCEDRIN (MIGRAINE); ACETAMINOPHEN, ASPIRIN AND CAFFEINE; CODEINE, ASPIRIN, APAP FORMULA NO. 3; ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE; CODEINE, ASPIRIN, APAP FORMULA NO. 4; CODEINE, ASPIRIN, APAP FORMULA NO. 2
bis(3,5-dibromosalicyl)fumarate-crosslinked hemoglobin A(0)  0   *Hemoglobin A Aspirin/*analogs & derivatives Blood Substitutes. Artif Cells Blood Substit Immobil Biotechnol 1996 Sep;24(5):533-51
nitroaspirin  175033-36-0   Aspirin/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors ; Cysteine Proteinase Inhibitors 		Blood Coagul Fibrinolysis 1996 Apr;7(2):206-9
NCX 4215  0   Aspirin/*analogs & derivatives. J Clin Invest 1995 Dec;96(6):2711
nitroxy-butyl-acetylsalicylic acid  0   Aspirin/*analogs & derivatives. Thromb Res 1995 Dec 1;80(5):367
bromoaspirin  77382-69-5   Aspirin/*analogs & derivatives. Nat Struct Biol 1995 Aug;2(8):637-43
aspalatone  0   Aspirin/*analogs & derivatives. Arzneimittelforschung 1994 Oct;44(10):1122-6
Trisok  0   *Aspirin *Chlortetracycline *Dibucaine *Tetracaine Drug Combinations. Oral Surg Oral Med Oral Pathol 1994 Apr;77(4):331-4
diaspirin-cross-linked cyanomethemoglobin  0   Aspirin/*analogs & derivatives Methemoglobin/*analogs & derivatives. J Lab Clin Med 1993 Sep;122(3):301-8
diaspirin-cross-linked hemoglobin  0   *Hemoglobins Aspirin/*analogs & derivatives Blood Substitutes. J Lab Clin Med 1993 Sep;122(3):301-8
acetylsalicylate, glycine, lysine drug combination  0   *Glycine Aspirin/*analogs & derivatives Drug Combinations Lysine/*analogs & derivatives Air Pollutants, Occupational Wound Healing. Klin Khir 1992;(2):24-6
poly(beta-(acetylsalicylyloxy)ethylmethacrylate)  80044-26-4   *Polymethacrylic Acids Aspirin/*analogs & derivatives. J Biomater Sci Polym Ed 1991;2(1):1
guaiacol salicylate  87-16-1   Aspirin/*analogs & derivatives Guaiacol/*analogs & derivatives. Yao Hsueh Hsueh Pao 1990;25(9):664
aspirin, codeine drug combination  130320-48-8   *Aspirin *Codeine Drug Combinations. Lancet 1990;335(8683):224
mono(3,5-dibromosalicyl)fumarate  93705-06-7 2-Butenedioic acid (E)-, mono((3,5-dibromo-2-hydroxyphenyl)methyl) ester  Aspirin/*analogs & derivatives. J Biol Chem 1989;264(11):6191
hemoglobin XL99alpha  0   *Hemoglobins Aspirin/*analogs & derivatives Blood Substitutes. Proc Natl Acad Sci USA 1987;84(20):7280
3,5-diiodoaspirin  36415-60-8   Aspirin/*analogs & derivatives. Acta Pharm Suec 1986;23(5):295
bis(2,3-dibromosalicyl)fumarate  106044-07-9   Aspirin/*analogs & derivatives. Biochim Biophys Acta 1986;874(1):76
aspirin, caffeine, codeine drug combination  0   *Aspirin *Caffeine *Codeine Drug Combinations. Can Dent Assoc J 1986;52(4):325SYNALGOS-DC
aspirin, dipyridamole drug combination  0   *Aspirin *Dipyridamole Drug Combinations.
Pharma Action Platelet Aggregation Inhibitors 		ROFO 1985;143(6):718ASPIRIN AND DIPYRIDAMOLE; AGGRENOX
pharodoran  138230-31-6   *Aspirin Drug Combinations. Prakt Zubn Lek 1985;33(2):54
Triaminicin  138331-08-5   *Aspirin *Chlorpheniramine *Phenylpropanolamine Drug Combinations. JAMA 1985;253(18):2646
aspirin, metoclopramide drug combination  0   *Aspirin *Metoclopramide Drug Combinations. Cephalalgia 1984;4(2):107
godamed  0   *Aspirin *Glycine Drug Combinations. Urologie (Ausg A) 1984;23(3):178
Robaxisal  8058-35-3   *Aspirin *Methocarbamol Drug Combinations. Br J Clin Prac 1984;38(3):107ROBAXISAL; METHOCARBAMOL AND ASPIRIN
Norgesic forte  88566-80-7 Benzoic acid, 2-(acetyloxy)-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione and N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)ethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)  *Aspirin *Caffeine *Orphenadrine Drug Combinations. Ther Drug Monit 1983;5(4):401INVAGESIC FORTE; ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE; ORPHENGESIC; INVAGESIC; NORGESIC FORTE; NORGESIC; ORPHENGESIC FORTE
aspirin, codeine, phenacetin, phenobarbital drug combination  52453-04-0   *Aspirin *Codeine *Phenacetin *Phenobarbital Drug Combinations. Eksp Med Morfol 1983;22(1):39
DP-neuralgen  86290-92-8 Benzoic acid, 2-(acetyloxy)-, mixt. with (S-(R*,S*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate 2-naphthalenesulfonate and N-(4-ethoxyphenyl)acetamide  *Aspirin *Phenacetin Drug Combinations Dextropropoxyphene/*analogs & derivatives. Cas Lek Cesk 1983;122(3):83
bis(3,5-dibromosalicyl)adipate  75848-76-9   Aspirin/*analogs & derivatives. Biochemistry 1982;21(23):5901
bis(3,5-dibromosalicyl)glutarate  75848-75-8   Aspirin/*analogs & derivatives. Biochemistry 1982;21(23):5901
Midol  83514-22-1 Benzoic acid, 2-(acetyloxy)-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, N-(4-ethoxyphenyl)acetamide and alpha-(1-(methyl(3-phenyl-2-propenyl)amino)ethyl)benzenemethanol hydrochloride  *Aspirin *Caffeine *Phenacetin Drug Combinations Ephedrine/*analogs & derivatives. Arch Intern Med 1982;142(8):1583MIDOL
dibromoacetylsalicylic acid  0   Aspirin/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1982;37(1):139
2-guaiacolethanol acetylsalicylate  82273-25-4 Benzoic acid, 2-(acetyloxy)-, 2-(2-methoxyphenoxy)ethyl ester  Aspirin/*analogs & derivatives Guaiacol/*analogs & derivatives. Bell Chim Farm 1982;120(12):730
Kominek's mixture  81424-60-4 Benzoic acid, 2-(acetyloxy)-, mixt. with 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 2-methyl-2-propyl-1,3-propanediyl dicarbamate and N,N,alpha-trimethyl-10H-phenothiazone-10-ethanamine mono  *Aspirin *Chlorpromazine *Meprobamate *Phenobarbital *Promethazine Drug Combinations. Stomalologiia (Mosk) 1981;60(6):24
methylsulfinylmethyl 2-acetoxybenzoate  76432-33-2 Benzoic acid, 2-(acetyloxy)-, (methylsulfinyl)methyl ester  Aspirin/*analogs & derivatives. J Pharm Sci 1981;70(7):750
succinylamino aspirin  80434-80-6 Benzoic acid, 2-(acetyloxy)-5-((3-carboxy-1-oxopropyl)amino)  Aspirin/*analogs & derivatives. Biochem Biophys Res Commun 1981;101(1):258
aspirin phenylalanine ethyl ester  76748-72-6 L-Phenylalanine, N-(2-(acetyloxy)benzoyl)-, ethyl ester  Aspirin/*analogs & derivatives. J Theor Biol 1980;87(4):757
succinyldisalicylic acid  578-19-8   Aspirin/*analogs & derivatives. J Biol Chem 1981;256(13):7046
safapryn  51900-85-7   *Acetaminophen *Aspirin Drug Combinations Delayed-Action Preparations. Lancet 1981;1(8223):777
methyl acetylsalicylic acid  580-02-9   Aspirin/*analogs & derivatives. Agents Actions 1980;10(5):457
aspirin, aluminum hydroxide, magnesium hydroxide drug combination  0   *Aluminum Hydroxide *Aspirin *Magnesium Hydroxide Drug Combinations.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		J Allergy Clin Immunol 1981;67(3):247
dimethylaminoethyl acetylsalicylate  52461-48-0 benzoic acid, 2-(acetyloxy)-, 2-(dimethylamino)ethyl ester  Aspirin/*analogs & derivatives. Boll Chim Farm 1980;119(6):331
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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