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Atractyloside

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Definition: A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.     
Pharmacological Action Enzyme Inhibitors 		Other names Atractylic Acid; Acid, Atractylic; Atractylate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
atractyligenine  0   Atractyloside/*analogs & derivatives. Pharmazie 2002 Jun;57(6):374-6
6'-O-dansyl-gamma-aminobutyryl atractyloside  84872-88-8   *Dansyl Compounds Atractyloside/*analogs & derivatives. Biochem Biophys Res Commun 1986;134(1):266
6'-O-4-azidobenzoylatractyloside  83579-68-4 19-Norkaur-16-en-18-oic acid, 2-((6-O-(4-azidobenzoyl)-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl)oxy)-15-hydroxy-, dipotassium salt, labeled with carbon-14, (2beta,4alpha,15alpha)  *Azides Atractyloside/*analogs & derivatives. FEBS Lett 1982;143(2):268
arylazidoatractyloside  65792-55-4 19-Norkaur-16-en-18-oic acid, 2-((6-O-(4-((4-azido-2-nitrophenyl)amino)-1-oxobutyl)-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl)oxy)-15-hydroxy-, dipotassium salt, (2beta,4alpha,15alpha)  *Azides Atractyloside/*analogs & derivatives. Biochim Biophys Acta 548(1):30;1979
carboxyatractyloside  35988-42-2   Atractyloside/*analogs & derivatives. Biochem J 172(2):333;1978; Biochemistry 12(8):1508;1973; Biochemistry 1979;18(19):4209; Biochemistry 1980;19(3):548; Biochim Biophys Acta 503(2):193;1978; FEBS Lett 56(2):194;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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