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Azacitidine

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Definition: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.     
Pharmacological Action Antimetabolites, Antineoplastic; Enzyme Inhibitors 		Other names Azacytidine; NSC102816; NSC 102816; 5 Azacytidine; Vidaza; Pharmion Brand of Azacitidine; NSC-102816; 5-AzacytidineDrugs* : VIDAZA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2'-deoxy-5,6-dihydro-5-azacytidine  0   Azacitidine/*analogs & derivatives. Epigenetics. 2011 Jun;6(6):769-76
S110 compound  0   *Oligonucleotides Azacitidine/*analogs & derivatives. Mol Cancer Ther 2010 May;9(5):1443-50
CP 4200  0   Azacitidine/*analogs & derivatives. Mol Cancer Ther 2010 May;9(5):1256-64
2'-deoxy-N4-(2-(4-nitrophenyl)ethoxycarbonyl)-5-azacytidine  0   Azacitidine/*analogs & derivatives. Cancer Lett 2008 Aug 8;266(2):238-48
2'-beta-deoxy-6-azacytidine  0   Azacitidine/*analogs & derivatives. J Phys Chem B 2007 Jun 7;111(22):6263-71
POG-8498 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Etoposide Methotrexate Prednisone Thioguanine Vincristine 6-Mercaptopurine. Pediatr Blood Cancer 2007 Mar;48(3):262-7
D-ZAPO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Prednisolone Vincristine. Cancer 1989;63(8):1457
MAZE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Amsacrine Azacitidine Etoposide. Hamatol Bluttransfus 1987;30:35
N(4),N(4)-dimethyl-5-azacytidine  27826-77-3   Azacitidine/*analogs & derivatives. Neoplasma 1985;32(3):293
N(4)-methyl-5-azacytidine  27826-76-2   Azacitidine/*analogs & derivatives. Neoplasma 1985;32(3):293
5-aza-2'-deoxycytidine-5'-monophosphate  66642-55-5   Azacitidine/*analogs & derivatives. Mol Pharmacol 1984;25(3):436
6-azacytidine  3131-60-0   Azacitidine/*analogs & derivatives. JNCI 1984;72(4):833
5-aza-2'-deoxycytidine-5'-triphosphate  72052-96-1 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)  Azacitidine/*analogs & derivatives Cytidine Triphosphate/*analogs & derivatives. Mol Pharmacol 1983;24(1):109
2'-deoxy-6-methyl-5-azacytidine  80646-65-7 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methyl  Azacitidine/*analogs & derivatives. Nucleic Acids Symp Ser 1981;9:21
fazarabine  65886-71-7   Azacitidine/*analogs & derivatives Stereoisomerism.
Pharma Action Antineoplastic Agents 		J Med Chem 22(10):1230;1979
decitabine  2353-33-5   Azacitidine/*analogs & derivatives Myelodysplastic Syndromes DNA Modification Methylases/antagonists & inhibitors.
Pharma Action Antimetabolites, Antineoplastic ; Enzyme Inhibitors ; Teratogens 		Biochem Pharmacol 28(8):1443;1979; Cancer Res 1979;39(10):3822; Cancer Res 37:1636;1977; Cancer Res 38(9):2673;1978; FEBS Lett 78(2):244;1977; JNCI 1979;63(4):1035; Neoplasma 25(4):385;1978DACOGEN
5,6-dihydro-5-azacytidine  62488-57-7 4-amino-5,6-dihydro-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one  Azacitidine/*analogs & derivatives.
Pharma Action Antimetabolites, Antineoplastic 		Cancer Res 37:1956;1977; Cancer Treat Rep 60(11):1671;1976; J Med Chem 20(6):806;1977
5'-azacytidine 5'-triphosphate  2226-74-6   Azacitidine/*analogs & derivatives Cytidine Triphosphate/*analogs & derivatives. Anal Biochem 71(1):60;1976; Med Ped Oncol 2(3):265;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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