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Azauridine
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Definition
: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Pharmacological Action
Antimetabolites, Antineoplastic
;
Dermatologic Agents
Other names
6 Azauridine; 6-
Azauridine; 2-
beta-
D-
Ribofuranosyl-
1,2,4-
triazine-
3,5(2H,4H)-
d
Substance
CAS Registry & name
Categories
Source
Drugs
*
azaribine
2169-64-4
Azauridine/*analogs & derivatives.
J Am Acad Dermatol 1985;13(4):567
6-
azauridine 5'-
triphosphate
6198-30-7
Azauridine/*analogs & derivatives
Uridine Triphosphate/*analogs & derivatives.
J Biol Chem 1980;255(18):8402
3-
deaza-
6-
azauridine
56707-91-6 3(2H)-
Pyridazinone, 5-
hydroxy-
2-
beta-
D-
ribofuranosyl
Azauridine/*analogs & derivatives.
Biochim Biophys Acta 520(1):229;1978
2-
thio-
6-
azauridine
27089-56-1
Azauridine/*analogs & derivatives
Thiouridine/*analogs & derivatives.
Cancer Chemother Rep 58(3):345;1974