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Azocines

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Definition:      
Examples Cyclazocine; Oxazocines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(2-(1-azacyclooctanyl)-5-(trifluoromethyl))phenyl-3-nicotinoylthiourea  0   *Azocines Thiourea/*analogs & derivatives. PLoS One. 2011;6(8):e23246.
2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo(1,2,3-fg-3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid hexyl ester  0   *Azocines Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Neurotox Res 2011 Jul;20(1):40-50
N,N'-((1,1'-(oxybis(pentane-5,1-diyl))bis(1H-1,2,3-triazole-4,1-diyl))bis(phenylmethylene))bis(6-(2-(methylamino)propanamido)-5-oxodecahydropyrrolo(1,2-a)azocine-3-carboxamide)  0   *Azocines *Dipeptides. J Med Chem 2011 May 12;54(9):3306-18
N-benzhydryl-5-(2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo(1,2-a)(1,5)diazocine-8-carboxamide  0   *Azocines *Benzhydryl Compounds. J Med Chem 2011 Apr 28;54(8):2714-26
azocino(4,3-b)indole  0   *Azocines *Indoles. J Org Chem. 2011 Jan 7;76(1):335-8
13-cyclohexyl-6-(-1-isopropylpyrrolidin-3-yl)-5,6,7,8-tetrahydrothieno(2,3-4,5)pyrrolo(2,1-a)(2,5)benzodiazocine-11-carboxylic acid  0   *Azocines. ChemMedChem 2009 Oct;4(10):1695-713
3-iodocytisine  0   *Alkaloids *Azocines *Quinolizines. Neuropharmacology. 2009 Sep;57(3):259-67
N-benzyl-N-(6,7,8,9,10,11-hexahydro-13H-azocino(2,1-b)quinazolin-13-ylidene)amine  0   *Azocines *Quinazolines. Pflugers Arch 2008 Feb;455(5):895-901
N,N'-(6H,12H-5,11-methanodibenzo(b,f)(1,5)diazocine-2,8-diyldi-2,1-ethanediyl)-bis(N-(3-(4-dimethylaminopyridinium)propyl)phenethylamine)dichloride  0   *Azocines *Pyridines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Neurochem Int. 2007 Jan;50(2):443-9
9-(2-fluoropyridinyl)cytisine  0   *Azocines *Pyridines Alkaloids. Bioorg Med Chem. 2003 Dec 1;11(24):5333-43
N-4-fluorobenzyl cytisine  0   *Azocines *Quinolizines. Eur J Pharmacol. 2003 Jun 20;471(2):85-96
N-3-oxobutylcytisine  0   *Azocines *Quinolizines. Eur J Pharmacol. 2003 Jun 20;471(2):85-96
1,2-bis-N-cytisinylethane  0   *Azocines *Quinolizines Alkaloids. Eur J Pharmacol. 2003 Jun 20;471(2):85-96
N-hydroxybenzazocine  0   *Azocines. Angew Chem Int Ed Engl. 2002 Dec 16;41(24):4686-8
buflavine  0   *Azocines *Amaryllidaceae Alkaloids. J Org Chem 2002 Aug 9;67(16):5846-9
2,9-dimethoxy-11,12-dihydrodibenzo(e,g)(1,2)diazocine 5,6-dioxide  0   *Azocines *Cyclic N-Oxides. J Med Chem 2001 Dec 6;44(25):4313-24
dibenzodiazocine-2,6-dione  0   *Azocines. Chemosphere 2001 Apr;43(1):75-81
SMP-300  0   *Azocines *Pyrroles. Jpn J Pharmacol 2000 Oct;84(2):196-205
okaramine B  0   *Azetidines *Azocines *Indole Alkaloids. Biosci Biotechnol Biochem 2000 Jul;64(7):1519-21
cyanosafracin B  0   *Azocines *Quinones. Org Lett 2000 Aug 10;2(16):2545-8
N-((1-(6-amidinobutylhexylcarbamoyl)-3-methyl-1-butylcarbamoyl)methyl)-1-phenyl-2-((8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methanobenzazocin-3-yl)methyl)cyclopropanecarboxamide  0   *Azocines *Cyclopropanes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Aug 10;43(16):2992-3004
N-((1-(5-amidinobutylpentylcarbamoyl)-3-methyl-1-butylcarbamoyl)methyl)-1-phenyl-2-((8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methanobenzazocin-3-yl)methyl)cyclopropanecarboxamide  0   *Azocines *Cyclopropanes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Aug 10;43(16):2992-3004
5,6-dehydrolupanine  0   *Azocines *Sparteine. Arch Pharm Res 1994 Dec;17(6):393-7
rhombifoline  529-78-2   *Azocines Quinolizines. Arch Pharm Res 1994 Dec;17(6):393-7
AL 05741  0   *Azocines. J Ocul Pharmacol Ther 1998 Oct;14(5):437-45
N-(1-ethyloctahydroazocin-3-yl)-6-methoxy-1H-benzotriazole-5-carboxamide  0   *Azocines *Triazoles. Bioorg Med Chem Lett 1998 Aug 4;8(15):1973-8
KAA 276  0   *Azocines *Benzimidazoles. Biol Pharm Bull 1998 Apr;21(4):350-355
8-carbamoyl-1,2,3,6,7,8,9,10a-octahydro-5H,10H-pyrrolo(1,2-a)(1,4)diazocin-5,10-dione  0   *Azocines *Pyrroles. Bioorg Med Chem 1997 Nov;5(11):2029-40
baptifoline  732-50-3 7,14-Methano-4H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocin-4-one, 7,7a,8,9,10,11,13,14-octahydro-9-hydroxy-, (7R-(7alpha,7abeta,9alpha,14alpha))  *Alkaloids Azocines Pyridines Quinolizines. J Pharm Biomed Anal 1997 Mar;15(6):839-43
1-((5-((4-(2-methoxy-phenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azocinone  0   *Azocines *Furans. J Med Chem 1995 Oct 13;38(21):4198-210
BA 41899  166020-57-1   *Azocines. J Med Chem 1995 Jul 21;38(15):2946-54
methyl-(2,5-dioxo-3-(3-(tosylguanidino)propyl)-octahydro-1,4-diazocin-1-yl)acetate  0   *Azocines. FEBS Lett 1994 Nov 2;354(2):143-8
methyl (2,5-dioxo-3-(3-(tosylguanidino)propyl)-4-methyl-octahydro-1,4-diazocin-1-yl)acetate  0   *Azocines. FEBS Lett 1994 Nov 7;354(2):143-8
2,8-bis(3'-pyridylmethyl)-6H,12H-5,11-methanodibenzo(b,f)(1,5)diazocine  0   *Azocines *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Oct 15;36(21):3202-6
Troeger's base  529-81-7   *Azocines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem Oct 15;36(21):3202-6
SA 3443  128620-82-6   *Azocines *Disulfides. Jpn J Pharmacol 1991;55(2):275
1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuro(2,3-c)azocin-10-ol  100448-10-0   *Azocines *Benzofurans. J Med Chem 1986;29(5):748
apogalanthamine  26955-02-2   *Azocines *Galantamine. J Pharmacobiodyn 1985;8(11):917
4-(cyclopropylmethyl)-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocin-9-amine  80770-03-2   *Azocines. J Med Chem 1985;28(6):728
zenazocine  77272-67-4   *Azocines. Neuropeptides 1985;5(4-6):375
tonazocine  71461-18-2   *Azocines. Neuropeptides 1985;5(4-6):375
asocainol  77400-65-8   *Azocines. Naunyn Schmiedebergs Arch Pharmacol 1984;326(2):155
3-(mercaptomethyl)-3,4,5,6-tetrahydro-2-oxo-1H-1-benzazocine-1-acetic acid  89177-63-9   *Azocines. J Med Chem 1984;27(6):816
5-(2',5'-dimethylphenyl)-6-oxa-1-azabicyclo(3.3.0)octane  92473-68-2 2H-Furo(2,3-b)pyrrole, 2-(2,5-dimethylphenyl)hexahydro  *Azocines. Pharm Acta Helv 1983;58(9-10):256
6-phenyl-1,3,4,6-tetrahydro-2H-5,1-benzothiazocin-2-one-1-carboxylic acid  85099-00-9 2H-5,1-Benzothiazocine-1(6H)-carboxylic acid, 3,4-dihydro-2-oxo-6-phenyl  *Azocines. Acta Pol Pharm 1982;39(1-3):27
quadazocine  69924-29-4   *Azocines.
Pharma Action Narcotic Antagonists 		Eur J Pharmacol 1982;78(3):307; Eur J Pharmacol 1982;84(1-2):17
1,5-diazacyclooctane-N-monoacetic acid  61040-13-9 1,5-Diazocine-1(2H)-acetic acid, hexahydro-, hydrobromide (2:3)  *Azocines Ligands. J Am Chem Soc 98(22):6944;1976
anagyrine  486-89-5 7,7a,8,9,10,11,13,14-octahydro-7,14-memethano-4H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocin-4-one  *Alkaloids *Azocines Quinolizines. J Toxicol Env Health 1(6):887-899;1976
6-(beta-bromoethyl)-10,11-methylenedioxy-5,6,7,8- tetrahydrodibenz(c,e)azocine  58532-43-7   *Azocines. Chem Pharm Bull 23(11):3036;1975; Jap J Pharmacol 26:607;1976
origen  14368-24-2   *Azocines. Ther Hung 23(1):21;1975; Zh Nevropatol Psikhiatr 74(5):912;1974
octogen  2691-41-0   *Azocines.
Pharma Action Explosive Agents 		Bull Environ Contam Toxicol 10(5):302;1973; Gig Sanit 11:17;1975; Rapid Commun Mass Spectrom 1997;11(1):63-70
heptamethyleneimine  1121-92-2   *Azocines. Nature 244(412):176;1973
dibenzothioazocines  0   *Azocines. J Pharm Soc Jpn 93(8):991;1973; J Pharm Soc Jpn 97(1):24-31;1977
3-chlorodibenzoxazocine  0   *Azocines. J Pharm Soc Jap 93(8):1003;1973
N-benzyl-6-dimethyl-8-hydroxy-9-methoxybenzazocine succinate  0   *Azocines. Jap J Pharmacol (Suppl)24:86;1974
compound 15219  25684-28-0 2H-1,5-benzoxazocin-3-ol, 3,4-dihydro-6-methyl-, (+/-)  *Azocines. Res Commun Chem Pathol Pharmacol 4(1):25;1972
cytisine  485-35-8 1,2,3,4,5,6-hexahydro-1,5-methano-8H- pyrido(1,2-a)(1,5)diazocin-8-one  *Alkaloids Azocines Quinolizines Nicotine/antagonists & inhibitors. Acta Polon Pharm 29(5):490;1972; Biokhimiia 43(7):1150;1978
FLA 69  77242-25-2 1,5-Diazocine-1(2H)-carbodithioic acid, hexahydro-5-methyl  *Azocines. J Neurochem 18(12):2491;1971
Gr 858  37642-31-2 cyclopenta(b)pyrrol-6-ol, octahydro-1,2-dimethyl-, hydriodide  *Azocines. Arch Int Pharmacodyn Ther 199(1):144;1972
2-azacyclooctanone  673-66-5   *Azocines. J. Pharm Sci 60(7):1058;1971
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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