Definition: A ubiquitous membrane transport protein found in the plasma membrane of diverse cell types and tissues, and in nuclear, mitochondrial, and Golgi membranes. It is the major integral transmembrane protein of the erythrocyte plasma membrane, comprising 25% of the total membrane protein. It exists as a dimer and performs the important function of allowing the efficient transport of bicarbonate across erythrocyte cell membranes in exchange for chloride ion.
Other names Erythrocyte Membrane Band 3 Protein; Erythrocyte Anion Transport Protein; Band 3 Protein; Anion Transport Protein, Erythrocyte; Protein, Band III; Protein, Band 3; Chloride-Bicarbonate Exchanger, AE1; Anion Exchanger, Erythrocyte; AE1 Cl HCO3 Exchanger; AE1 Chloride Bicarbonate Exchanger; Protein Band 3; Erythrocyte Membrane Anion Transport Protein; Erythrocyte Anion Exchanger; Capnophorin; Band III Protein; AE1 Gene Product; AE1 Cl- HCO3- Exchanger; AE1 Chloride-Bicarbonate Exchanger; AE1 Anion Exchanger
