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Barbiturates

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Definition: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.  GEN or unspecified; prefer specifics   
See Also Anesthetics, Intravenous; Anticonvulsants; Hypnotics and Sedatives
Examples Amobarbital; Barbital; Hexobarbital; Mephobarbital; Methohexital; Murexide; Pentobarbital; Phenobarbital; Secobarbital; Thiobarbiturates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-ethyl-5-(piperidin-1-yl)barbituric acid  0   *Barbiturates *Piperidines. Acta Crystallogr C. 2012 Feb;68(Pt 2):o65-70
5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)trione  0   *Barbiturates *Indoles. Clin Cancer Res. 2011 Oct 15;17(20):6490-9.
1,5-di(but-2-enyl)-5-ethylbarbituric acid  0   *Barbiturates. Acta Crystallogr C. 2010 Jan;66(Pt 1):o55-8
5-allyl-5-isopropyl-1-methylbarbituric acid  0   *Barbiturates. Acta Crystallogr C. 2010 Jan;66(Pt 1):o55-8
6-hydroxyuridine 5'-monophosphate  0   *Barbiturates Uridine Monophosphate/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2008;(52):297-8
N-(4-(methanesulfonylpiperazin-1-yl)-2,4,6-trioxopyrimidin-4-ylmethyl)-4-((2-methylquinolin-4-yl)methoxy)benzamide  0   *Barbiturates *Benzamides. Bioorg Med Chem Lett 2007 Jan 1;17(1):266-71
thiazolidinonyl 2-thiobarbituric acid  0   *Barbiturates *Thiazolidines. Eur J Med Chem. 2006 Oct;41(10):1223-9
thiazolidinonyl 2-oxobarbituric acid  0   *Barbiturates *Thiazolidines. Eur J Med Chem. 2006 Oct;41(10):1223-9
5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione  0   *Barbiturates *Benzopyrans. J Biol Chem 2006 Apr 14;281(15):10066-72
bis-(1,3-diethylthiobarbiturate) trimethine oxonol  0   *Barbiturates *Isoxazoles. Am J Physiol Cell Physiol. 2005 Jul;289(1):C224-9
5-(4-(2-hydroxyethyl)piperazin-1-yl)-5-(4-(4-iodophenoxy)phenyl)pyrimidine-2,4,6-trione  0   *Barbiturates *Piperazines. J Med Chem 2005 May 5;48(9):3400-9
5-ethyl-1-phenyl-5-(3,4,5,6-tetrafluorophthalimido)barbituric acid  0   *Barbiturates *Phthalimides. Eur J Pharmacol. 2002 Oct 25;453(2-3):325-34
2,2'-pyridil into 5,5'-(2-pyrilidine)bisbarbituric acid  0   *Barbiturates. Org Lett 2002 Mar 7;4(5):811-3
talbutal  115-44-6   *Barbiturates. LOTUSATE
1,3-dimethyl-5-(4-dimethylaminophenyl)-methylene-2,4,6(1H, 3H)-pyrimidinetrione  0   *Barbiturates. Spectrochim Acta A Mol Biomol Spectrosc 2001 May;57(6):1183-90
1,3-dimethyl-5-(4,4'-bis(dimethylaminophenyl)methylene)-2,4,6-(1H,3H)-pyrimidine-trione  0   *Barbiturates. Spectrochim Acta A Mol Biomol Spectrosc 2001 May;57(6):1183-90
5-ethyl-5-isobutylbarbituric acid  1135-61-1   *Barbiturates. Eur J Med Chem 2000 Jan;35(1):97-105
1,3-dimethoxymethyl-5,5-diphenylbarbituric acid  0   *Barbiturates. J Chromatogr B Biomed Sci Appl 1998 Jun 12;710(1-2):149-55
5-ethyl-5-(4-fluorobenzoylpropyl)barbituric acid  0   *Barbiturates. Yao Hsueh Hsueh Pao 1995;30(8):610-4
bis(1,3-dibutylbarbituric acid)pentamethine oxonol  0   *Barbiturates *Isoxazoles. Am J Physiol 1995 Oct;269(4 Pt 1):C1063-72
Pyridium Plus  0   *Atropine *Barbiturates *Phenazopyridine Drug Combinations. Pediatr Emerg Care 1995 Apr;11(2):103-6
violuric acid  87-39-8   *Barbiturates. Eksp Klin Farmakol 1995 Jan-Feb;58(1):49-52
spasmoplus  0   *Codeine *Aminopyrine *Barbiturates *Diphenylacetic Acids Drug Combinations. Landarzt 1967 Oct 20;43(29):1436-9; Med Welt 1966 Jan 8;2:115-7
secbutabarbital  125-40-6   *Barbiturates.
Pharma Action Hypnotics and Sedatives 		BUTABARB; SODIUM BUTABARBITAL; SARISOL NO. 1; SARISOL NO. 2; BUTICAPS; BUTISOL SODIUM; BUTABARBITAL SODIUM; SARISOL; BUTALAN; BUTABARBITAL
allobarbital  52-43-7 2,4,6(1H,3H,5H)-Pyrimidinetrione , 5,5-di-2-propenyl  *Barbiturates.
metharbital  50-11-3 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-1-methyl  *Barbiturates. GEMONIL
bucolome  841-73-6 2,4,6(1H,3H,5H)-Pyrimidnetrione, 5-butyl-1-cyclohexyl  *Barbiturates.
heptabarbital  509-86-4 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohepten-1-yl)-5-ethyl  *Barbiturates.
cyclobarbital  52-31-3 2,4,6-(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-5-ethyl  *Barbiturates.
proxibarbal  2537-29-3 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)  *Barbiturates.
Pharma Action Hypnotics and Sedatives
5-(3-benzyloxy)benzyl-1-((2-hydroxyethoxy)methyl)barbituric acid  138660-09-0   *Barbiturates Uridine Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1993 Oct 5;46(7):1273-83
5,5-dimethylbarbituric acid  24448-94-0   *Barbiturates. Arch Toxicol 1992;66(6):413-22
N(1),N(3)-diethyl-5-(5'-(N(1''),N(3'')-diethyl-2,4,6-trioxo-1,2,3,4,5,6-hexahydropyrimidin-5''-ylidene)-penta-1'3'-diene-1'-yl)barbituric acid  0   *Barbiturates. Biochim Biophys Acta 1991;1059(3):265
halonal  106602-54-4   *Barbiturates. Zh Nevropatol Psikhiatr 1989;89(10):69
Pabialgin P  34356-64-4   *Barbiturates Antipyrine/*analogs & derivatives Drug Combinations. Acta Pol Pharm 1989;46(3):248
2-hydroxylamino-5-ethyl-5-propylbarbituric acid  102902-43-2   *Barbiturates. Acta Physiol Pharmacol Bulg 1988;14(2):56
5-ethyl-5-(1,3-dimethylbutyl)-5-barbituric acid  2964-06-9   *Barbiturates. Life Sci 1988;43(6):477
acetaminophen, butalbital, caffeine drug combination  0   *Acetaminophen *Barbiturates *Caffeine Drug Combinations.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		Clin Ther 1987;10(1):69ESGIC; FIORICET W/ CODEINE; TRIAD; ANOQUAN; BUTALIBITAL, ACETAMINOPHEN AND CAFFEINE; FIORICET; FEMCET; PHRENILIN WITH CAFFEINE AND CODEINE; BUTALBITAL, ACETAMINOPHEN AND CAFFEINE; BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE; MEDIGESIC PLUS; ESGIC-PLUS
bis(1,3-dibutylbarbiturate)trimethine oxonol  110425-49-5   *Barbiturates *Isoxazoles.
Pharma Action Fluorescent Dyes 		J Cell Physiol 1987;131(3):434
1,5,5-triallylbarbituric acid  66843-15-0   *Barbiturates. Yakugaku Zasshi 1986;106(6):504
5-aminomethylene-1,3-dibutylbarbituric acid  99108-12-0   *Barbiturates. Arch Pharm (Weinheim) 1985;318(9):821
5-allyl-beta-oxypropylmalonylurea  0   *Barbiturates. Med Clin (Barc) 1985;85(10):431
propallylonal  545-93-7   *Barbiturates. Arzneimittelforschung 1985;35(8):1334
bucolome N-glucuronide  98641-06-6   *Barbiturates. Xenobiotica 1985;15(7):615
spasmo-eunalgit  138230-24-7   *Aminopyrine *Barbiturates *Papaverine *Plant Extracts Drug Combinations. Cesk Patol 1984;20(4):215
5-ethyl-5-(1,3-dimethyl-1-butenyl)barbituric acid  72961-79-6   *Barbiturates. J Pharmacol Exp Ther 1984;230(1):82
5-(1,3-dimethylbutyl)-5-barbituric acid  78092-58-7   *Barbiturates. Eur J Pharmacol 1983;94(3-4):319
4'-hydroxybutobarbitone  82168-60-3   *Barbiturates. Xenobiotica 1983;13(3):179
1,5-dimethylbarbituric acid  7391-67-5   *Barbiturates. Br J Clin Pharmacol 1983;15(4):459
neo-secatropin  8056-06-2   *Barbiturates *Belladonna Alkaloids *Ergotamines *Succinates Drug Combinations. Z Urol Nephrol 1981;74(12):873
ajmaline phenylbarbiturate  81424-61-5 Ajmalan-17,21-diol, (17R,21alpha)-, mixt. with 5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione  *Ajmaline *Barbiturates Drug Combinations. Clin Ter 1981;99(2):155
Beuthanasia Special  8024-20-2 Beuthanasia  *Barbiturates. Clin Toxicol 1981;18(8):965
barbituric acid  67-52-7   *Barbiturates. Z Med Lab Diag 1981;22(3):129
isouramil  3914-34-9   *Barbiturates. Prog Clin Biol Res 1981;55:725
barbiturate receptor  0   *Receptors, GABA-A Barbiturates. J Neurochem 1981;37(1):1
1',2'-epoxyvinylbital  75319-56-1 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylbutyl)-5-oxiranyl  *Barbiturates. Xenobiotica 1980;10(3):159
butobarbital  77-28-1   *Barbiturates.
Pharma Action Hypnotics and Sedatives 		Postgrad Med J 1980;56(655):363
1,3-dimethylbarbital  714-59-0   *Barbiturates. Anal Biochem 1980;106(2):351
5-(2-cyclohexylidene-ethyl)-5-ethylbarbiturate  22173-64-4 5-(2-cyclohexylideneethyl)-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione  *Barbiturates.
Pharma Action Anticonvulsants ; Convulsants 		J Pharmacol Exp Ther 1980;213(2):332
reladorm  71789-18-9 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-5-ethyl-, calcium salt (2:1), mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one  *Barbiturates *Diazepam Drug Combinations. Mater Med Pol 11(2):173;1979
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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