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Benzodiazepines

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Definition: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.  do not confuse with BENZODIAZEPINONES   
Examples Alprazolam; Benzodiazepinones; Chlordiazepoxide; Clorazepate Dipotassium; Estazolam; Medazepam; Midazolam; Triazolam 		Other names Benzodiazepine Compounds; Benzodiazepine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PF-184563  0   *Benzodiazepines *Triazoles Receptors, Vasopressin/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5684-7.
evacetrapib  0   *Benzodiazepines Cholesterol Ester Transfer Proteins/antagonists & inhibitors. JAMA. 2011 Nov 16;306(19):2099-109.
7-methoxy-8-(5-(4-(1,3-benzothiazol-2-yl)-2-methoxyphenoxy)pentyl)oxy-(11aS)1,2,3,11a-tetra-hydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one  0   *Benzodiazepines *Pyrroles. Bioorg Med Chem. 2010 Jul 1;18(13):4747-61
8-ethynyl-6-(2'-pyridine)-4H-2,5,10b-triazabenzo(e)azulene-3-carboxylic acid ethyl ester  0   *Benzodiazepines *Imidazoles GABA-A Receptor Agonists. Neuropharmacology 2010 Dec;59(7-8):612-8
5-(2-chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazol(3,4b)(1,4)benzodiazepine  0   *Benzodiazepines *Pyrazoles. Cell Cycle 2010 Aug 15;9(16):3364-75
GSK525762A  0   *Benzodiazepines. Nature. 2010 Dec 23;468(7327):1119-23
TKM0150  0   *Benzodiazepines *Pyrazoles Protein-Tyrosine Kinases/antagonists & inhibitors. Arzneimittelforschung. 2010;60(5):282-5
benzopyrano(4,3-c)-1,5-benzodiazepine  0   *Benzodiazepines *Benzopyrans. C R Biol 2010 Mar;333(3):214-9
2-amino-4-(methyl(2-methylphenyl)amino)-11H-pyrimido(4,5-b)(1,5)benzodiazepin-6-ium  0   *Benzodiazepines *Pyrimidines. Acta Crystallogr C 2010 Apr;66(Pt 4):e154-8
2-amino-4-(piperidin-1-yl)-11H-pyrimido(4,5-b)(1,5)benzodiazepin-6-ium  0   *Benzodiazepines *Pyrimidines. Acta Crystallogr C 2010 Apr;66(Pt 4):e154-8
EVT 201  0   *Benzodiazepines. Sleep Med 2010 Jan;11(1):23-30
4-(3,5-dihydroxybenzyl)-N-(2-methyl-4-((1-methyl-4,10-dihydropyrazolo(3,4-b)(1,5)benzodiazepin-5(1H)-yl)carbonyl)benzyl)piperazine-1-carboxamide  0   *Benzodiazepines *Pyrazoles Receptors, Oxytocin/agonists. Neuropharmacology 2010 Jan;58(1):69-77
RO 4882224  0   *Benzodiazepines *Triazoles. Bioorg Med Chem Lett 2009 Oct 15;19(20):5940-4
3-bromo-10-difluoromethyl-9H-imidazo(1,5-a)(1,2,4)triazolo(1,5-d)(1,4)benzodiazepine  0   *Benzodiazepines *Imidazoles. Psychopharmacology (Berl). 2009 Jan;202(1-3):207-23
limazepine D  0   *Benzodiazepines. J Nat Prod 2009 Apr;72(4):690-5
limazepine B1  0   *Benzodiazepines. J Nat Prod 2009 Apr;72(4):690-5
1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)urea  0   *Benzodiazepines *Phenylurea Compounds Receptor, Cholecystokinin A/antagonists & inhibitors Receptor, Cholecystokinin B/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):2138-47
4-cyclohexylmethyl-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione  0   *Benzodiazepines. J Pharm Pharmacol. 2009 Mar;61(3):339-406
7-chloro-4-(cyclohexylmethyl)-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione  0   *Benzodiazepines. J Pharm Pharmacol. 2009 Mar;61(3):399-406
quino(7,8-b)benzodiazepine  0   *Benzodiazepines *Quinolines. Molecules. 2008;13(11) (dup#2):2880-93
PWZ-029  0   *Benzodiazepines. Brain Res 2008 May 7;1208:150-9
ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate  0   *Benzodiazepines *Imidazoles. J Med Chem 2008 Aug 14;51(15):4730-43
2-(5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-(1,2,4)oxadiazol-3-yl)phenyl)acetamide  0   *Benzodiazepines Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):3101-12
GWL 78  0   *Benzodiazepines *Dipeptides. Mol Cancer Ther 2008 May;7(5):1319-26
RS 779  0   *Benzodiazepines *Cyclic S-Oxides. BMC Cancer 2007;7:207
RS 678  0   *Benzodiazepines *Cyclic S-Oxides. BMC Cancer 2007;7:207
4-(2-hydroxyphenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine  0   *Benzodiazepines. Acta Crystallogr C 2007 Jul;63(Pt 7):o426-30
CNS 7056  0   *Benzodiazepines GABA-A Receptor Agonists. Anesthesiology 2007 Jul;107(1):60-6
DRH-417  0   *Benzodiazepines *Pyrroles. J Chemother 2007 Feb;19(1):66-78
2-hydroxymethylolanzapine  0   *Benzodiazepines. Clin Pharmacokinet 1999 Sep;37(3):177-93
RO0281501  0   *Benzodiazepines. Mol Cancer Ther 2006 Aug;5(8):1950-7
alpha5IA-II  0   *Benzodiazepines *Pyridines. Eur J Pharmacol. 2005 Dec 5;526(1-3):240-50
5,11-dihydro-pyrido(2,3-b)(1,5)benzodiazepine  0   *Benzodiazepines. Bioorg Med Chem Lett 2006 Feb 15;16(4):954-9
RWJ-351647  0   *Benzodiazepines. Br J Pharmacol 2005 Nov;146(5):654-61
6-fluoro-10-(3-(2-methoxyethyl)-4-methylpiperazin-1-yl)-2-methyl-4H-3-thia-4,9-diazabenzo(f)azulene  0   *Benzodiazepines *Thiophenes. J Pharmacol Exp Ther 2005 Dec;315(3):1265-77
RY 023  0   *Benzodiazepines. Alcohol Clin Exp Res 2005 Aug;29(8):1390-401
EGIS-8332  0   *Benzodiazepines Excitatory Amino Acids/antagonists & inhibitors. Eur J Pharmacol. 2005 Sep 5;519(1-2):58-67
EGIS-10608  0   *Benzodiazepines Excitatory Amino Acids/antagonists & inhibitors. Eur J Pharmacol. 2005 Sep 5;519(1-2):58-67
2,3-dimethyl-6-phenyl-12H-(1,3)dioxolo(4,5-h)imidazo(1,2-c)(2,3)benzodiazepine  0   *Benzodiazepines *Dioxoles Receptors, AMPA/antagonists & inhibitors. J Med Chem 2005 Jul 14;48(14):4618-27
fluoroquinolone-pyrrolo(2,1-c)(1,4)benzodiazepine  0   *Benzodiazepines *Fluoroquinolones. Bioorg Med Chem. 2005 Mar 15;13(6):2021-9
mmy-SJG compound  0   *Benzodiazepines *Pyrroles. Nucleic Acids Res 2005;33(10):3283-91
desmethylclobazam  0   *Benzodiazepines. Forensic Sci Int 2004 Jul 16;143(2-3):205-9
olanzapine-fluoxetine combination  0   *Benzodiazepines *Fluoxetine Drug Combinations. Med Lett Drugs Ther 2004 Mar 15;46(1178):23-4SYMBYAX; OLANZAPINE; FLUOXETINE HYDROCHLORIDE
GI 181771X  0   *Benzodiazepines Receptor, Cholecystokinin A/agonists. Am J Physiol Gastrointest Liver Physiol 2004 Aug;287(2):G363-9
BMS225975  0   *Benzodiazepines *Imidazoles. Cancer Res 2004 Jun 1;64(11):3974-80
2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-4-(2-biphenylylcarbonyl)-1H-1,4-benzodiazepine  0   *Benzodiazepines *Imidazoles. Yao Xue Xue Bao 2001 Jun;36(6):423-6
1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one  0   *Benzodiazepines Azulenes Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Cancer Res 2003 Sep 15;63(18):6008-15
8,9-dimethoxy-6-(4-bromophenyl)-11H-(1,2,4)triazolo(4,5-c)(2,3)benzodiazepin-3(2H)-one  0   *Benzodiazepines *Triazoles. J Med Chem 2003 Aug 14;46(17):3758-61
4,5,6,7-tetrahydroimidazo-(4,5,1- jk)(1,4)benzodiazepin-2 (1 H)-one  0   *Benzodiazepines *Imidazoles. J Mol Model (Online) 2002 Aug;8(8);258-65
(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one  0   *Benzodiazepines *Organophosphorus Compounds. Kaohsiung J Med Sci. 2003 Jan;19(1):6-12
5-phenyl-3-ureido-1,5-benzodiazepine  0   *Benzodiazepines. Bioorg Med Chem 2002 Nov;10(11):3571-81
indiplon  0   *Benzodiazepines *Thiophenes.
Pharma Action Hypnotics and Sedatives ; GABA Modulators 		Drugs R D 2002;3(3):197-9
8-chloro-6-(4-phenethyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine  0   *Benzodiazepines *Piperazines. J Med Chem 2002 Nov 7;45(23):5136-49
Bz-423  0   *Benzodiazepines. J Clin Invest 2002 Oct;110(8):1123-32
1-methyl-6-phenyl-4H-s-triazo-(4,3-alpha)(1,4)benzodiazepinone  0   *Benzodiazepines. J Pharm Sci 2002 May;91(5):1274-86
3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1-acetic acid methyl ester  0   *Benzodiazepines. Bioorg Med Chem Lett 2002 Apr 22;12(8):1225-7
RY 024  0   *Benzodiazepines. Neurobiol Learn Mem 2002 Jul;78(1):1-10
BD-1158  0   *Benzodiazepines. Ann Univ Mariae Curie Sklodowska [Med] 2001;56():275-9
pyrrolo(2,1-c)(1,4)benzodiazepine  0   *Benzodiazepines *Pyrroles. J Org Chem 2001 Apr 20;66(8):2881-3
circumdatin C  0   *Alkaloids *Benzodiazepines Aspergillus ochraceus. J Org Chem 2001 Apr 20;66(8):2784-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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