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Benzodiazepinones

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Definition:   do not confuse with BENZODIAZEPINES   
Examples Anthramycin; Bromazepam; Clonazepam; Devazepide; Diazepam; Flumazenil; Flunitrazepam; Flurazepam; Lorazepam; Nitrazepam; Oxazepam; Pirenzepine; Prazepam; Temazepam
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo(e)pyrrolo(1,2-a)(1,4)diazepin-8-yl)oxy)hexyl-1,2-dihydro-1gamma6-naphtho(1,8-cd)isothiazole-1,1-dione  0   *Benzodiazepinones *Benzothiazoles. Bioorg Med Chem. 2012 Jan 15;20(2):789-800.
1-(4-amino-3-chlorophenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. Biochemistry. 2012 Feb 28;51(8):1787-95.
1-(4-aminophenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. Biochemistry. 2012 Feb 28;51(8):1787-95.
3-hydroxy-7-bromo-5-(ortho-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one  0   *Benzodiazepinones. Eksp Klin Farmakol. 1996 May-Jun;59(3):61-3.
XMD 8-92  0   *Benzodiazepinones Mitogen-Activated Protein Kinase 7/antagonists & inhibitors. Clin Cancer Res. 2011 Jun 1;17(11):3527-32.
benzo(1,4)diazepin-2-one  0   *Benzodiazepinones. J Phys Chem B. 2010 Dec 9;114(48):16020-8
SG 2285  0   *Benzodiazepinones *Pyrroles. Cancer Res 2010 Sep 1;70(17):6849-58
4-(2-hydroxyphenyl)-1,5-benzodiazepin-2-one  0   *Benzodiazepinones. C R Biol 2010 Mar;333(3):214-9
circumdatin J  0   *Benzodiazepinones *Quinazolinones. J Org Chem 2008 Jun 6;73(11):4245-7
circumdatin E  0   *Benzodiazepinones *Quinazolinones. J Org Chem 2008 Jun 6;73(11):4245-7
7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one  0   *Benzodiazepinones. Cell 2010 Apr 16;141(2):231-42
sclerotigenin  0   *Benzodiazepinones. Chem Commun (Camb). 2009 Jan 28;(4):445-7
PF 00477736  0   *Benzodiazepinones *Pyrazoles. Mol Cancer Ther 2008 Aug;7(8):2394-404
circumdatin B  0   *Benzodiazepinones. J Org Chem 2008 Jun 6;73(11):4245-7
circumdatin A  0   *Benzodiazepinones. J Org Chem 2008 Jun 6;73(11):4245-7
circumdatin I  0   *Benzodiazepinones. J Antibiot (Tokyo) 2008 Jan;61(1):40-2
2-(((3,5-difluorophenyl)acetyl)amino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)propanamide  0   *Benzodiazepinones Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Biol Chem 2000 Nov 3;275(44):34086-91
Z-360  0   *Benzodiazepinones. Regul Pept 2008 Feb 7;146(1-3):46-57
1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones. Bioorg Med Chem. 2008 Mar 1;16(5):2200-11
2-(3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo(b,e)(1,4)diazepin-8-yl)-N,N-dimethylacetamide  0   *Benzodiazepinones. J Med Chem 2007 Aug 23;50(17):4162-76
2-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-(3-methyl-4-oxo-4,5-dihydro-3H-benzo(d)(1,2)diazepin-5-yl)propanamide  0   *Benzodiazepinones Alanine/*analogs & derivatives Amyloid Precursor Protein Secretases/antagonists & inhibitors. Bioorg Med Chem Lett 2007 Jul 15;17(14):4006-11
1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)urea  0   *Benzodiazepinones *Phenylurea Compounds. J Med Chem 2007 Apr 5;50(7):1685-92
1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones. Chirality 2007 Jan;19(1):16-21
3,5-dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):575-81
TDP 665759  0   *Benzodiazepinones. Mol Cancer Ther 2006 Jan;5(1):160-9
TDP 521252  0   *Benzodiazepinones. Mol Cancer Ther 2006 Jan;5(1):160-9
1-ethyl-2-(3-(1-ethylquinolin-2(1H)-ylidene)prop-1-enyl)-6-((6-oxo-6-((2-(2-(2-(4-(2-oxo-2-(6-oxo-5,6-dihydro-11H-pyrido(2,3-b)(1,4)benzodiazepin-11-yl)ethyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)amino)hexanoyl)amino)quinolinium  0   *Benzodiazepinones *Quinolinium Compounds. J Med Chem 2005 Dec 1;48(24):7847-59
PAT(17)PZ compound  0   *Benzenesulfonates *Benzodiazepinones. J Med Chem 2005 Dec 1;48(24):7847-59
circumdatin H  0   *Benzodiazepinones Electron Transport Complex I/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Jun;58(6):416-9
3-acetylamino-N-(1-(((2-hydroxy-5-oxo-tetrahydrofuran-3-yl)carbamoyl)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)succinamic acid  0   *Benzodiazepinones 4-Butyrolactone/*analogs & derivatives. J Med Chem 2004 Dec 16;47(26):6455-8
1,3-bis(8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxy)propyl diester  0   *Benzodiazepinones *Imidazoles Receptors, GABA-A/antagonists & inhibitors. J Med Chem 2003 Dec 18;46(26):5567-70
8-iodobretazenil  0   *Benzodiazepinones Iodine Radioisotopes Ligands. Nucl Med Biol 2003 Feb;30(2):191-8
GI 0122  0   *Benzodiazepinones. J Med Chem 2003 Jul 31;46(16):3476-82
3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)butyramide  0   *Benzodiazepinones. J Med Chem 2003 Jun 5;46(12):2275-8
8-((6-(1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo(e)indol-3-yl)-6-oxohexyl)oxy)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one  0   *Benzodiazepinones. J Med Chem 2003 May 22;46(11):2132-51
N-hydroxy-2-(7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo(1,2,5-f)thiadiazepine-1,1-dioxide)propanamide  0   *Benzodiazepinones *Hydroxamic Acids. J Med Chem 2003 May 8;46(10):1811-23
N-hydroxy-2-(7-benzyloxy-2,3,4,5-tetrahydrobenzo(1,2,5-f)thiadiazepine-1,1-dioxide)-4-methylpentanamide  0   *Benzodiazepinones *Hydroxamic Acids. J Med Chem 2003 May 8;46(10):1811-23
8-(5-(4-(trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam V  0   *Benzodiazepinones. J Med Chem 2003 Jan 30;46(3):364-73
3-benzyl-1-(4-guanidinylphenyl)-4-phenyl-2H-1,4-benzodiazepin-2-one  0   *Benzodiazepinones *Guanidines Receptors, Bradykinin/antagonists & inhibitors. Peptides 2001 Sep;22(9):1397-402
1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)  0   *Benzodiazepinones *Pyrroles. J Med Chem 2001 Mar 1;44(5):737-48
3-(1-methyl-4-(1-methyl4-(1-methyl-4-(8-(2'-carboxamidoethyloxy)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one)pyrrole-2-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)propionamidine  0   *Benzodiazepinones *Distamycins. Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1219-29
8-chloro-6-phenyl-4H-(1,2,4)-triazolo(4,3-a)(1,5)benzodiazepin-5(6H)-one  0   *Benzodiazepinones. Acta Crystallogr C 2000 Feb;56( Pt 2):258-9
FR 208419  0   *Benzodiazepinones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2000 Jan;48(1):1-15
8-(2,3-epoxypropoxy)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one  0   *Benzodiazepinones *Pyrroles. J Med Chem 1999 Oct 7;42(20):4028-41
SB 223245  0   *Acetic Acids *Benzodiazepinones Receptors, Vitronectin/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jul 5;9(13):1807-12
benzolactam V7  0   *Benzodiazepinones. Bioorg Med Chem Lett 1999 May 17;9(10):1371-4
CFM 2  0   *Benzodiazepinones. Eur J Pharmacol 1999 Mar 5;368(2-3):149-59
CFM 1  0   *Benzodiazepinones. Eur J Pharmacol 1999 Mar 5;368(2-3):149-59
4-methyl-5-ethoxalyl-1H-2,3,4,5-tetrahydro-1,5-benzodiazepin-2-one  0   *Benzodiazepinones. Acta Pol Pharm 1998 Sep-Oct;55(5):397-402
L 768673  0   *Acetamides *Benzodiazepinones Potassium Channels/antagonists & inhibitors. J Med Chem 1997 Nov 21;40(24):3865-8
DU 124884  147512-71-8   *Benzodiazepinones *Indoles. Anal Chem 1997 Jul 1;67(11):1903-6
KC 9048  147436-25-7   *Benzodiazepinones *Indoles. Anal Chem 1997 Jun 1;67(11):1903-6
1-(4-butanoyl-(4-bis(2-chloroethyl)amino)phenylalanine ethyl ester)-7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one  0   *Benzodiazepinones Melphalan/*analogs & derivatives. J Med Chem 1997 May 23;40(11):1726-30
YF 476  0   *Benzodiazepinones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 1997 Jan 31;40(3):331-41
SB 208651  0   *Benzodiazepinones. Bioorg Med Chem 1994 Sep;2(9):897-908
tilivalline  80279-24-9   *Benzodiazepinones. Anticancer Drug Des 1995 Mar;10(2):167-76
YM 26365  0   *Benzodiazepinones Renin/antagonists & inhibitors. Eur J Pharmacol 1994 Dec 27;271(2-3):341-8
7-((4-guanidinophenyl)aminocarbonyl)-3-oxo-4-phenethyl-1,4-benzodiazepine-2-acetic acid  0   *Benzodiazepinones. J Med Chem 1995 Jan 6;38(1):9-12
L 740093  154967-59-6 Urea, N-(5-(3-azabicyclo(3.2.2)non-3-yl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)-, (R)  *Benzodiazepinones *Phenylurea Compounds. Mol Pharmacol 1994 Nov;46(5):943-8
RU 34030  122321-07-7 6H-Imidazo(1,5-a)(1,4)benzodiazepin-6-one, 3-(cyclopropylcarbonyl)-8-fluoro-4,5-dihydro-5-methyl  *Benzodiazepinones. Gen Pharmacol 1994 May;25(3):589-97
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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