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Benzylidene Compounds

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Definition: Compounds containing the PhCH= radical.  = benzals; DF: BENZYLIDENE CPDS   
Examples Stilbenes; Styrenes; Tyrphostins 		Other names Compounds, Benzylidene
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(E)-2-(2-hydroxybenzylideneamino)-3-methylbutanoic acid  0   *Benzylidene Compounds *Butyric Acids. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb;86():231-41
2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone  0   *Benzylidene Compounds *Cyclohexanones. Molecules. 2011;16(11):9728-38.
3,5-bis(2,4-difluorobenzylidene)-4-piperidone  0   *Benzylidene Compounds *Piperidones. Mol Cancer Ther. 2011 Nov;10(11):2146-56.
(E)-N-carbamimidoyl-4-((3,4-dimethoxybenzylidene)amino)benzenesulfonamide  0   *Benzylidene Compounds *Sulfonamides. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Dec 15;84(1):156-63
2,6-bis(4-(3-(dimethylamino)propoxy)benzylidene)cyclohexanone  0   *Benzylidene Compounds *Cyclohexanones. PLoS One. 2011;6(9):e24377.
1,2-bis(3,5-dibenzylidene-4-oxopiperidin-1-yl)ethane-1,2-dione  0   *Benzylidene Compounds *Piperidones. ChemMedChem. 2011 Oct 4;6(10):1892-9.
5-(4-hydroxy-3,5-dimethylbenzylidene)thiazolidine-2,4-dione  0   *Benzylidene Compounds *Thiazolidinediones. Curr Neurovasc Res. 2011 Feb;8(1):25-34.
5-bis(4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone  0   *Benzylidene Compounds *Piperidones. Breast Cancer Res Treat 2011 Jul;128(1):97-107
P-N,N-dimethylaminobenzylidenemalononitrile  0   *Benzylidene Compounds *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Aug;79(3):443-50
(E)-2-(2,6-dichloro-4-hydroxybenzylidene)hydrazinecarboximidamide  0   *Benzylidene Compounds *Hydrazines. Acta Crystallogr C. 2011 Aug;67(Pt 8):o310-4
2-(5-(3-phenoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid  0   *Benzylidene Compounds *Thiazoles. Bioorg Med Chem. 2010 Jul 1;18(13):4630-8
2-(4-chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one  0   *Benzylidene Compounds *Thiazoles Lipoxygenase Inhibitors. J Med Chem 2011 Mar 24;54(6):1943-7
4-hydroxyphenylmethylene hydantoin  0   *Benzylidene Compounds *Hydantoins. Nat Prod Commun 2010 Oct;5(10):1623-6
1,2-(1-(1,1-bis(4-hydroxyphenyl)methylidene)tetramethylene)ferrocene  0   *Benzylidene Compounds *Ferrous Compounds. Dalton Trans 2010 Aug 28;39(32):7444-50
1,2-(1-(1,1-bis(4-hydroxyphenyl)methylidene)trimethylene)ferrocene  0   *Benzylidene Compounds *Ferrous Compounds. Dalton Trans 2010 Aug 28;39(32):7444-50
3-(3',5'-dimethoxy-4'-hydroxy-benzylidene)-2-indolinone  0   *Indoles *Benzylidene Compounds. Eur J Pharm Sci. 2010 May 12;40(2):143-7
benzylidene-3-methylimidazolidinone  0   *Benzylidene Compounds *Imidazoles. J Am Chem Soc. 2010 Feb 10;132(5):1498-9
2-nitrobenzylidene acetal  0   *Acetals *Benzylidene Compounds. J Org Chem. 2009 Nov 20;74(22):8647-58
N-n-decyl-2-oxo-5-nitro-1-benzylidene-methylamine  0   *Benzylidene Compounds *Cyclohexanones. J Mol Model 2009 Oct;15(10):1281-90
2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one  0   *Benzylidene Compounds *Indenes. Eur J Pharmacol 2009 Jun 24;613(1-3):1-9
1,4-benzylidene-bis(S,S)-4-yl-3,5-bis(1-hydroxyethyl)-1,2,4-triazole  0   *Benzylidene Compounds *Triazoles. Dalton Trans. 2008 Nov 28;(44):6103-5
(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine  0   *Benzylidene Compounds *Guanidines. Bioorg Med Chem. 2009 Apr 1;17(7):2852-8
1-(2-(2,5-dimethoxyphenylthio)benzylidene)semicarbazide  0   *Benzylidene Compounds *Semicarbazides. Bioorg Med Chem. 2009 Apr 1;17(7):2852-8
2,4-(bis-(2,4-dihydroxybenzylidene))-dihydrazinoquinazoline  0   *Quinazolines *Benzylidene Compounds. Anal Chim Acta. 2009 Mar 9;635(2):207-13
UPR1024  0   *Benzylidene Compounds *Hydantoins. Mol Cancer Ther 2008 Feb;7(2):361-70
5-((2-fluoro-3-methylphenyl)methylene)-2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-(1)benzopyrano(3,4-f)quinolin-9-ol  0   *Benzopyrans *Benzylidene Compounds. Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19244-9
9-(2-(4-fluorophenyl)vinyl)-9H-carbazole  0   *Benzylidene Compounds *Carbazoles. Acta Crystallogr C 2007 Dec;63(Pt 12):o754-7
3,5-bis(2-fluorobenzylidene)piperidin-4-one  0   *Benzylidene Compounds *Piperidones. J Biol Chem Sep 28;292(39):28609-18
2-((4-dimethylaminophenyl)methylene)-5-iodo-3(2H)-benzofuranone  0   *Benzofurans *Benzylidene Compounds Iodine Radioisotopes. Biochem Biophys Res Commun 2007 Sep 14;361(1):116-21
5-iodo-2-((4-methylaminophenyl)methylene)-3(2H)-benzofuranone  0   *Benzofurans *Benzylidene Compounds Iodine Radioisotopes. Biochem Biophys Res Commun 2007 Sep 14;361(1):116-21
2-((4-aminophenyl)methylene)-5-iodo-3(2H)-benzofuranone  0   *Benzofurans *Benzylidene Compounds Iodine Radioisotopes. Biochem Biophys Res Commun 2007 Sep 14;361(1):116-21
2,6-bis(3-bromo-4-hydroxybenzylidene)cyclohexanone  0   *Benzylidene Compounds *Cyclohexanones Acetylesterase/antagonists & inhibitors. J Med Chem 2007 Apr 19;50(8):1973-7
N-(3-(3-methoxyphenyl)-3-phenyl-2-propenyl)cyclobutanecarboxamide  0   *Benzylidene Compounds *Cyclobutanes Receptor, Melatonin, MT2/antagonists & inhibitors. J Med Chem 2006 Dec 14;49(25):7393-403
N-(3,3-bis(3-methoxyphenyl)-2-propenyl)acetamide  0   *Acetamides *Benzylidene Compounds Receptor, Melatonin, MT2/agonists. J Med Chem 2006 Dec 14;49(25):7393-403
N-acetyl-4-((2-hydroxybenzylidene)amino)benzenesulfonamide monohydrate  0   *Benzylidene Compounds *Sulfonamides. Acta Crystallogr C. 2005 Jul;61(Pt 7):o460-3
N-acetyl-4-((5-bromo-2-hydroxybenzylidene)amino)benzenesulfonamide monohydrate  0   *Benzylidene Compounds *Sulfonamides. Acta Crystallogr C. 2005 Jul;61(Pt 7):o460-3
7-hydroxy-3-(3',4',5'-trimethoxybenzylidene)chroman-4-one  0   *Benzylidene Compounds *Chromones. Chem Pharm Bull (Tokyo) 2006 Aug;54(8):1193-5
7-methoxy-3-(4'-methoxybenzylidene)chroman-4-one  0   *Benzylidene Compounds *Chromones. Chem Pharm Bull (Tokyo) 2006 Aug;54(8):1193-5
3-(4-chloro-3-nitrobenzylidene)pentane-2,4-dione  0   *Benzylidene Compounds *Ketones. Mol Pharmacol 2006 Jun;69(6):1861-70
4'-hydroxybenzylidene-2-methyl-imidazolin-5-one-3-acetate  0   *Benzylidene Compounds *Imidazoles. J Comput Chem 2005 Nov 15;26(14):1487-96
bis(4-nitrobenzylidenamino)guanidine  0   *Benzylidene Compounds *Guanidines. Dokl Biochem Biophys 2004 Nov-Dec;399:376-9
bis(4-(dimethylamino)benzylidenamino)guanidine  0   *Benzylidene Compounds *Guanidines. Dokl Biochem Biophys 2004 Nov-Dec;399:376-9
N-(4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy)benzylidene)-N-tert-butylamine N-oxide  0   *Benzylidene Compounds. Arch Biochem Biophys 2005 Mar 15;435(2):336-46
2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone  0   *Benzylidene Compounds *Pentanones DNA Topoisomerases, Type I/antagonists & inhibitors. Biochem Pharmacol 2004 Jul 15;68(2):293-303
2,3-di-O-benzyl-4,6-O-benzylidene mannopyranosyl phosphite  0   *Benzylidene Compounds Mannose/*analogs & derivatives. Carbohydr Res. 2003 Jul 22;338(15):1531-4
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide  0   *Benzylidene Compounds *Pyridines. Cancer Res. 2003 Oct 15;63(20):6942-7
2-hydroxyarylidene-4-cyclopentene-1,3-dione  0   *Benzylidene Compounds *Cyclopentanes. Bioorg Med Chem. 2002 Oct;10(10):3257-65
4-(2-(p-hydroxybenzoyl)vinyl)phenyl nicotinate  0   *Benzylidene Compounds *Nicotinic Acids. Leuk Res 2003 Jan;27(1):57-64
GW 4869  0   *Aniline Compounds *Benzylidene Compounds. J Biol Chem 2002 Oct 25;277(43):41128-39
6-hydroxy-2-(phenylmethylene)-3(2H)-benzofuranone  0   *Benzofurans *Benzylidene Compounds. Planta Med 1999 May;65(4):316-9
XR 9051  0   *Benzylidene Compounds *Tetrahydroisoquinolines. Br J Cancer 1999 Apr;79(11-12):1672-8
AT 760  0   *Benzylidene Compounds *Pyrroles. Bioorg Med Chem Lett 1998 Aug 4;8(15):2003-4
7-(4-methylbenzylidene)naltrexone  0   *Benzylidene Compounds Naltrexone/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4177-80
7-(2-methoxybenzylidene)naltrexone  0   *Benzylidene Compounds Naltrexone/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4177-80
ZK 805412  0   *Amidines *Benzylidene Compounds Stereoisomerism Factor Xa/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3551-6
3-benzylidene-1-ethynyl-1-phenyl-1,3-dihydroisobenzofuran  0   *Benzofurans *Benzylidene Compounds. Acta Crystallogr C 1998 Jan 15;54( Pt 1):109-11
RB25 compound  0   *Benzylidene Compounds Glycine/*analogs & derivatives Neprilysin/antagonists & inhibitors. Adv Exp Med Biol 1997;421:93-9
dryocrassin  12777-70-7   *Benzylidene Compounds *Cyclohexanones. Chung Kuo Chung Yao Tsa Chih 1996 Apr;21(4):206-7
T 686  152815-51-5   *Benzylidene Compounds *Succinimides. J Biochem (Tokyo) 1996 Dec;120(6):1203-8
XR 330  0   *Benzylidene Compounds *Piperazines. J Antibiot (Tokyo) 1996 Oct;49(10):1014-21
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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