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beta-Lactamases

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Definition: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.     
Examples Cephalosporinase; Penicillinase 		Other names beta Lactamases; beta Lactamase; beta-Lactamase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MK-7655  0   *Azabicyclo Compounds beta-Lactamases/antagonists & inhibitors. Org Lett. 2011 Oct 21;13(20):5480-3
MK 8712  0   *Monobactams beta-Lactamases/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Jul 15;21(14):4267-70
beta-lactamase CMY-42, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Microb Drug Resist 2011 Jun;17(2):165-9
ACT-6 beta-lactamases  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. J Antibiot (Tokyo). 2011 Apr;64(4):317-20
beta-lactamase GOB-1, Elizabethkingia meningoseptica  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2000 Jul;44(7):1878-86
(1S,5R)-(((4S)-azepan-4-ylamino)carbonyl)-7-oxo-2,6-diazabicyclo(3.2.0)heptane-6-sulfonic acid  0   *Bicyclo Compounds, Heterocyclic beta-Lactamases/antagonists & inhibitors. J Pharm Sci. 2010 Dec;99(12):4973-81
beta-lactamase NDM-1  EC 3.5.2.6   *beta-Lactamases.
beta-lactamase IMP-15, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Clin Microbiol Infect. 2010 Feb;16(2):126-31
beta-lactamase BEL-2, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2010 Jan;54(1):533-5
beta-lactamase CMY-32, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Biochemistry 2010 Feb 9;49(5):1014-23
beta-lactamase KPC-2, Klebsiella pneumoniae  EC 3.5.2.6   *beta-Lactamases. Euro Surveill 2010 Oct 1;15(1):19457
CTX-M-28 beta-lactamase, Klebsiella pneumoniae  EC 3.5.2.6   *beta-Lactamases. Pathol Biol (Paris) 2009 Jul;57(5):343-8
NXL 104  0   *Azabicyclo Compounds beta-Lactamases/antagonists & inhibitors. J Antimicrob Chemother 2009 Aug;64(2):326-9
beta-lactamase CTX-M-22, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Foodborne Pathog Dis 2009 Apr;6(3):297-304
beta-lactamase VIM-18, Pseudomonas aeruginosa  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. Antimicrob Agents Chemother 2009 Mar;53(3):1225-7
beta-lactamase VIM-11, Pseudomonas aeruginosa  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. Antimicrob Agents Chemother 2009 Mar;53(3):1225-7
beta-lactamase OXA-58, Acinetobacter radioresistens  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2009 Feb;53(2):843-4
beta-lactamase OXA-23, Acinetobacter radioresistens  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2009 Feb;53(2):843-4
beta-lactamase OXA-133, Acinetobacter radioresistens  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2009 Feb;53(2):843-4
BLI-489  0   *Lactams beta-Lactamases/antagonists & inhibitors. Antimicrob Agents Chemother 2009 Feb;53(2):370-84
beta-lactamase TEM-116, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Pathol Biol (Paris) 2008 Nov-Dec;56(7-8):429-34
LN 1-255  0   *Cyclic S-Oxides *Penicillins beta-Lactamases/antagonists & inhibitors. J Biol Chem 2009 Jan 9;284(2):945-53
beta-lactamase OXA-58, Acinetobacter baumannii  EC 3.5.2.6   *beta-Lactamases. Enferm Infecc Microbiol Clin 2008 Oct;26(8):481-4
beta-lactmase VIM-6, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Int J Antimicrob Agents 2008 Nov;32(5):446-9
beta-lactamase IND, Chryseobacterium indologenes  EC 3.5.2.6   *beta-Lactamases Metalloproteins. Int J Antimicrob Agents 2008 Nov;32(5):398-400
metallo-beta-lactamase (VIM-13), Pseudomonas aeruginosa  EC 3.5.2.-   *beta-Lactamases. Antimicrob Agents Chemother. 2008 Oct;52(10):3589-96
carbapenemase-2, Klebsiella pneumoniae  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. Emerg Infect Dis. 2008 Jul;14(7):1178-80
beta-lactamase CTX-M-57, Salmonella typhimurium  EC 3.5.2.6   *beta-Lactamases. Int J Antimicrob Agents 2008 Jan;31(1):85-6
beta-lactamase IMP-18, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2006 Jun;50(6):2272-3
beta-lactamase TEM-158, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Antimicrob Agents Chemother 2007 Nov;51(11):4181-3
benzo(b)thiophene-2-ylboronic acid  0   *Boronic Acids *Thiophenes beta-Lactamases/antagonists & inhibitors. J Med Chem 2007 Nov 15;50(23):5644-54
beta-lactamase VIM-12, Klebsiella pneumoniae  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2005 Dec;49(12):5153-6
beta-lactamase IMP-7 protein, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. J Infect Chemother 2007 Aug;13(4):276-7
beta-lactamase SHV-31, Klebsiella pneumoniae  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2007 Mar;51(3):1082-4
beta-lactamase CTX-M-37, Salmonella enterica  EC 3.5.2.6   *beta-Lactamases. Int J Antimicrob Agents 2006 Oct;28(4):288-91
beta-lactamase CTX-M-2, Klebsiella pneumoniae  EC 3.5.2.-   *beta-Lactamases. Rev Argent Microbiol 2006 Apr-Jun;38(2):84-8
BJP-1 metallo-beta-lactamase, Bradyrhizobium japonicum  EC 3.5.2.   *beta-Lactamases. Antimicrob Agents Chemother 2006 Jun;50(6):1973-81
beta-lactamase PER-2, Enterobacteriaceae  EC 3.5.2.-   *beta-Lactamases. Enferm Infecc Microbiol Clin 2005 Nov;23(9):525-8
beta-lactamase OXA-58, Acinetobacter junii  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2006 Jan;50(1):399-400
beta-lactamase BEL-1, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2005 Sep;49(9):3743-8
beta-lactamase OXA-46, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2005 May;49(5):1973-80
beta-lactamase KPC-3, Enterobacter cloacae  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2005 Feb;49(2):776-8
beta-lactamase SHV-57, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins Drug Resistance, Microbial. Antimicrob Agents Chemother 2005 Feb;49(2):600-5
metallo-beta-lactamase L1, Stenotrophomonas maltophilia  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. Protein Sci 2004 Aug;13(8):2236-43
beta-lactamase Toho-1, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Antimicrob Agents Chemother 1995 Oct;39(10):2269-75
beta-lactamase CTX-M-26, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Antimicrob Agents Chemother 2004 Dec;48(12):4829-34
beta-lactamase CTX-M-25, E coli  EC 3.5.2.6   *beta-Lactamases *Escherichia coli Proteins. Antimicrob Agents Chemother 2004 Dec;48(12):4829-34
beta-lactamase KPC-3, Klebsiella pneumoniae  EC 3.5.2.6   *Bacterial Proteins *beta-Lactamases. Antimicrob Agents Chemother 2004 Dec;48(12):4793-9
beta-lactamase IMP-16, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Dec;48(12):4693-702
beta-lactamase GIM-1, Pseudomonas aeruginosa  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Dec;48(12):4654-61
beta-lactamase TEM-121, Enterobacter aerogenes  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Dec;48(12):4528-31
beta-lactamase DHA-1, Salmonella  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4492
beta-lactamase SHV-49, Klebsiella pneumoniae  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4466-9
beta-lactamase CTX-M-30, Citrobacter freundii  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4435-7
beta-lactamase TEM-131, Salmonella  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4263-70
beta-lactamase OXA-60, Ralstonia pickettii  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4217-25
beta-lactamase MIR-1, Enterobacter cloacae  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4177-82
beta-lactamase CMY-15, Citrobacter freundii  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4136-43
beta-lactamase CMY-14, Citrobacter freundii  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother 2004 Nov;48(11):4136-43
CARB-9 beta-lactamases  EC 3.5.2.6   *beta-Lactamases. Antimicrob Agents Chemother. 2004 Oct;48(10):4042-6
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