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Bombesin

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Definition: A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.     
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Bombesin 		Other names Dihydrochloride, Bombesin; Bombesin Dihydrochloride; Bombesin 14
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BAY 86-4367  0   Bombesin/*analogs & derivatives Fluorine Radioisotopes. J Nucl Med 2011 Feb;52(2):270-8
technetium 99m HYNIC-bombesin (7-14)  0   *Peptide Fragments *Organotechnetium Compounds Bombesin. Bioorg Med Chem Lett 2010 Nov 1;20(21):6182-4
bombesin (6-14), Tyr(6)-Apa(11)-4-Cl-Phe(13)-Nle(14)  0   *Bombesin *Peptide Fragments. Peptides 2010 Aug;31(8):1569-78
bombesin(6-14), Tyr(6)-Apa(11)-Phe(13)-Nle(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives Receptors, Bombesin/agonists. J Pharmacol Exp Ther 2010 Apr;333(1):51-9
DTPA(1)-Lys(3),Tyr(4)bombesin  0   *Pentetic Acid Bombesin/*analogs & derivatives Indium Radioisotopes. Cancer Biother Radiopharm. 2009 Aug;24(4):435-43
(99m)Tc-N(2)S(2)-Tat(49-57)-Lys(3)-bombesin  0   *Organotechnetium Compounds Bombesin/*analogs & derivatives. Int J Pharm. 2009 Jun 22;375(1-2):75-83
(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)  0   *Bombesin *Organometallic Compounds Copper Radiopharmaceuticals. Nucl Med Biol 2009 Feb;36(2):171-81
bomproamide  0   *Organometallic Compounds Bombesin/*analogs & derivatives. Bioconjug Chem 2008 Oct;19(10):2040-8
technetium 99m HYNIC-bombesin  0   *Organotechnetium Compounds Bombesin/*analogs & derivatives. Nucl Med Biol 2008 May;35(4):401-11
(18)F-FB-BBN-RGD  0   *Oligopeptides Bombesin/*analogs & derivatives. J Nucl Med.2008 Mar;49(3):453-61
DOTA-PEG(4)-bombesin (7-14)  0   *Heterocyclic Compounds, 1-Ring Bombesin/*analogs & derivatives. Eur J Nucl Med Mol Imaging 2007 Aug;34(8):1198-208
64Cu-1,4,7-triazacyclononane-1,4,7-triacetic acid-8-aminooctanoic acid-bombesin(7-14)amide  0   *Heterocyclic Compounds, 1-Ring *Peptide Fragments Bombesin Copper Radioisotopes. Proc Natl Acad Sci U S A 2007 Jul 24;104(30):12462-7
64Cu-DOTA-bombesin(1-14), Pro(1)-Tyr(4)  0   *Organometallic Compounds Bombesin/*analogs & derivatives Copper Radioisotopes. Bioconjug Chem 2007 May-Jun;18(3):724-30
86Y-DOTA-bombesin(1-14), Pro(1)-Tyr(4)  0   *Organometallic Compounds Bombesin/*analogs & derivatives Yttrium Radioisotopes. Bioconjug Chem 2007 May-Jun;18(3):724-30
99mTc-EDDA-HYNIC-(Lys 3)bombesin  0   *Organotechnetium Compounds Bombesin/*analogs & derivatives. Nucl Med Commun 2006 Apr;27(4):371-6
bombestatin, Bombina maxima  0   *Bombesin *Amphibian Proteins. Regul Pept 2005 Dec 15;132(1-3):102-6
Cu-DOTA-(Lys3)bombesin  0   *Organometallic Compounds Bombesin/*analogs & derivatives Copper. J Nucl Med 2004 Aug;45(8):1390-7
177Lu-DOTA-8-aminooctanoylbombesin (7-14)-amide  0   *Bombesin *Peptide Fragments Lutetium. Nucl Med Biol 2003 Feb;30(2):101-9
technetium 99m demobesin 1  0   *Organotechnetium Compounds Bombesin/*analogs & derivatives. Eur J Nucl Med Mol Imaging 2003 Feb;30(2):247-58
technetium Tc 99m bombesin, Leu(13)  0   *Organotechnetium Compounds Bombesin/*analogs & derivatives. Anticancer Res 2003 May-Jun;23(3A):2139-42
Re(H2O)(CO)3-diaminopropionic acid-SSS-bombesin(7-14)NH2  0   *Organometallic Compounds Bombesin/*analogs & derivatives. Anticancer Res 2003 Jan-Feb;23(1A):63-70
bombesin (6-14), Trp(6)-Leu(13)-psi(CH2NH)-Phe(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. J Pept Res 2001 May;57(5):383-9
AN 215  0   Bombesin/*analogs & derivatives Doxorubicin/*analogs & derivatives. Int J Cancer 2000 Nov 15;88(4):652-7
JMV 1458  0   *Bombesin. Eur J Pharmacol. 2000 Sep 1;403(1-2):17-25
DTPA-Pro(1),Tyr(4)bombesin  0   *Pentetic Acid Bombesin/*analogs & derivatives Indium Radioisotopes. Int J Cancer 1999 Nov 26;83(5):657-63
(phenylalanyl(6)-alanyl(11)-phenylalanyl(13)-Nle(14))Bn(6-14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Biochemistry 1999 Jun 1;38(22):7307-20
bombesin (7-14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Bioconjug Chem 1999 Mar-Apr;10(2):254-60
bombesin, Lys(3)  0   Bombesin/*analogs & derivatives. Bioconj Chem 1998 Mar-Apr;9(2):218-25
bombesin(8-13)-NH2, N-(3-iodobenzoyl)glutamyl-des-Met(14)  0   *Bombesin *Peptide Fragments Iodine Radioisotopes. J Nucl Med 1997 Aug;38(8):1221-9
acetyl-bombesin (7-14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Int J Pept Protein Res 1996 Dec;48(6):522-31
bombesin(6-14), Hca(6)-Leu(13)-psi(CH2N)-Tac(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives Bombesin/antagonists & inhibitors. Int J Cancer 1995 Oct 9;63(2):257-62
bombesin (6-14)-NH2, Phe(6)-Gln(7)-psi(CHCH)Leu(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Pancreas 1995 Apr;10(3):301-5
bombesin (6-14), Phe(6)-Leu(13)-psi(CH2NH)-Leu(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Regul Pept 1994 Oct 21;53(3):165-73
BIM 26226  0   *Peptide Fragments Bombesin/*analogs & derivatives. Regul Pept 1994 Oct 21;53(3):165-73
bombesin (6-13)-ethylamide, Phe(6)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Brain Res 1994 Aug 8;653(1-2):119-24
bombesin(6-14), Tpi(6)-Leu(13)-psi(CH2N)-Tpi(14)  142824-94-0 L-Histidinamide, N2-((2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indol-3-yl)carbonyl)-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-N-(1-((3-(aminocarbonyl)-1,3,4,9-tetrahydro-2H-pyrido(3,4-b)indol-2-yl)methyl)-3-methylbutyl)-, (1(S),6(S-(R*,R*)))  *Peptide Fragments Bombesin/*analogs & derivatives. Acta Oncol 1994;33(6):693-701
phyllolitorin, des-Trp-3,Leu-8  0   *Oligopeptides Pyrrolidonecarboxylic Acid/*analogs & derivatives Bombesin. Brain Res 1994 Feb 21;637(1-2):331-4
bombesin (6-14)-ethylamide, Phe(6)-des-Met(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Peptides 1993 Nov-Dec;14(6):1231-5
bombesin (6-13), Tyr(6) methyl ester  149440-24-4   *Peptide Fragments Bombesin/*analogs & derivatives. Mol Pharmacol 1993 May;43(5):762-74
gastrin releasing peptide (1-16)  0   *Peptide Fragments *Gastrin-Releasing Peptide Bombesin Gastrointestinal Hormones. Am J Physiol 1993 Apr;264(4 Pt 1):L345-50
gastrin releasing peptide (21-27)  55749-98-9 Ranatensin, 1-de(5-oxo-L-proline)-2-de-L-valine-3-de-L-proline-4-de-L-glutamine-10-L-leucine  *Oligopeptides *Peptide Fragments Bombesin Gastrointestinal Hormones. Am J Physiol 1993 Apr;264(4 Pt 1):L345-50
bombesin (6-14)-NH2, Phe(6)-Cpa(14)-psi(13-14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Am J Physiol 1993 Jan;264(1 Pt 1):L80-6
bombesin (6-14), D-Trp(6)-Leu(13)-psi(CH2NH)-Leu(14)  140163-54-8 Ranatensin, 1-de(5-oxo-L-proline)-2-de-L-valine-3-D-tryptophan-10-(N2-(2-amino-4-methylpentyl)-L-leucinamide)-11-de-L-methioninamide-, (S)  *Peptide Fragments Bombesin/*analogs & derivatives. Eur J Pharmacol 1992 Apr 22;214(2-3):239-45
bombesin (6-14), D-Phe(6)-Leu(13)-psi(CH2NH)-Phe(14)  123769-98-2 L-Histidinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-N-(1-(((2-amino-2-oxo-1-(phenylmethyl)ethyl)amino)methyl)-3-methylbutyl)-, (S-(R*,R*))  *Peptide Fragments Bombesin/*analogs & derivatives. Eur J Pharmacol 1992 Apr 22;214(2-3):239-45
BIM 189  142062-55-3 Ranatensin, 1-de(5-oxo-L-proline)-2-de-L-valine-3-D-phenylalanine-10-L-leucine-11-(4-chloro-L-phenylalaninamide)  *Peptide Fragments Bombesin/*analogs & derivatives. Eur J Pharmacol 1992 Apr 29;215(1):23-8
bombesin (6-13), Phe(6)-propylamide  0   *Peptide Fragments Bombesin/*analogs & derivatives. Cell Growth Differ 1992 Feb;3(2):111-8
bombesin (6-14), Thr(6)-Leu(13)-psi(CH2NH)-Met(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives. Biopolymers 1991 Oct 15;21(12):1397-1408
bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)  138147-78-1 L-Histidinamide, N2-((2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indol-3-yl)carbonyl)-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-N-(1-(((1-(aminocarbonyl)-3-methylbutyl)amino)methyl)-3-methylbutyl)-, (1(S),6(S-(R*,R*)))  *Peptide Fragments Bombesin/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Anticarcinogenic Agents 		Cancer Res 1991;51(21):5980
bombesin (6-13), Phe(6) methyl ester  130800-38-3   *Peptide Fragments Bombesin/*analogs & derivatives. Peptides 1991;12(3):493
bombesin (6-14), Nal(6)-Psi(13,14)-Phe(14)  123770-00-3   Bombesin/*analogs & derivatives. Cancer Res 1991;51(7):1798
bombesin, Psi(13,14)-Leu(14)  123809-85-8   Bombesin/*analogs & derivatives. Cancer Res 1991;51(7):1798
neuromedin C, Leu(9)-psi-(CH2NH)-Leu(10)  135467-88-8   *Peptide Fragments Bombesin/*analogs & derivatives. Pancreas 1990;5(4):408
neuromedin C, Ala(1)-Leu(9)-psi-(CH2NH)-Leu(10)  135467-89-9   *Peptide Fragments Bombesin/*analogs & derivatives. Pancreas 1990;5(4):408
bombesin, Leu(13)-psi-CH2NH-Leu(14)  115136-07-7   Bombesin/*analogs & derivatives. Biochem Biophys Res Commun 1988;156(3):1383
human probombesin C-terminal peptide  0   *Bombesin *Peptide Fragments *Protein Precursors Antigens, Neoplasm. Virchows Arch (A) 1987;411(2):185
bombesin, Phe(12), Leu(14)  108437-88-3   Bombesin/*analogs & derivatives. Am J Physiol 1987;252(3 Pt 1):G439
bombesin, Tyr(4), Phe(12)  108437-89-4   Bombesin/*analogs & derivatives. Am J Physiol 1987;252(3 Pt 1):G439
bombesin, Phe(12)  108437-87-2   Bombesin/*analogs & derivatives. Am J Physiol 1987;252(3 Pt 1):G439
neuromedin C  81608-30-2 Neuromedin C  *Bombesin *Peptide Fragments. Biochem Biophys Res Commun 1984;119(1):14
bombesin, Tyr(4)  67338-70-9 Bombesin, 4-L-tyrosine  Bombesin/*analogs & derivatives. J Biol Chem 1982;257(20):12024
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