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Botulinum Toxins

More information in Books or onNLM PubMed
Definition: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.  /antag permitted but consider also BOTULINUM ANTITOXIN   
Pharmacological Action Anti-Dyskinesia Agents; Poisons
See Also Botulism
Examples Botulinum Toxins, Type A 		Other names Clostridium botulinum Toxins; Botulin; Toxins, Clostridium botulinum; Toxins, Botulinum; Toxin, Botulinum; Botulinum Toxin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CNBTX-A  0   *Botulinum Toxins. J Am Acad Dermatol 2008 Mar;58(3):517-8
botulinum toxin type G  0   *Botulinum Toxins. J Biol Chem 2004 Jul 16;279(29):30865-70
Clostridium botulinum LL toxin  0   *Botulinum Toxins Hemagglutinins. J Protein Chem 1999 Oct;18(7):753-60
Clostridium botulinum L toxin  0   *Botulinum Toxins Lectins Hemagglutinins. J Protein Chem 1999 Oct;18(7):735-40
hemagglutinin 33 protein, Clostridium botulinum  0   *Botulinum Toxins Hemagglutinins Botulinum Toxins, Type A. J Protein Chem 1998 Jan;17(1):53-60
botulinum toxin type E  0   *Botulinum Toxins.
botulinum toxin type D  0   *Botulinum Toxins.
botulinum toxin type C  0   *Botulinum Toxins Poly(ADP-ribose) Polymerases. Electrophoresis 1996 Nov;17(11):1776-80
rimabotulinumtoxinB  EC 3.4.24.69   *Botulinum Toxins. MYOBLOC
botulinum toxin type F  0   *Botulinum Toxins.
NTNH protein, Clostridium botulinum  0   *Botulinum Toxins Neurotoxins. Curr Microbiol 1994 Aug;29(2):69-77
Clostridium botulinum M toxin  0   *Botulinum Toxins Neurotoxins. J Gen Microbiol 1993 Jan;139(Pt 1):79-86
exoenzyme C3, Clostridium botulinum  EC 2.4.2.-   *Botulinum Toxins *ADP Ribose Transferases Clostridium botulinum Recombinant Proteins. Biochem Biophys Res Commun 1990;166(3):1398
Clostridium botulinum toxoid  0   *Toxoids Botulinum Toxins Clostridium botulinum/immunology. Avian Dis 1982;26(2):340

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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