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Bridged Compounds

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Definition: Cyclic hydrocarbons that contain multiple rings and share one or more atoms.  DF: BRIDGED CPDS   
Examples Adamantane; Bicyclo Compounds 		Other names Compounds, Bridged
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(S)-(2,2)paracyclophane-4-carboxylate  0   *Bridged Compounds *Carboxylic Acids. Chirality. 2011 Oct;23(9):841-9
KNT 42  0   *Bridged Compounds Receptors, Opioid, kappa/agonists. Bioorg Med Chem Lett 2011 Jul 1;21(13):4104-7
KNT 93  0   *Bridged Compounds Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists. Bioorg Med Chem Lett 2011 Jul 1;21(13):4023-6
2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione  0   *Bridged Compounds *Sesquiterpenes. Chem Biol Interact 2011 Sep 30;193(3):204-15
11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene  0   *Bridged Compounds *Pyrimidines fms-Like Tyrosine Kinase 3/antagonists & inhibitors Janus Kinase 2/antagonists & inhibitors. J Med Chem 2011 Jul 14;54(13):4638-58
grandifloracin  0   *Bridged Compounds. Org Lett. 2011 Jun 17;13(12):3150-3
(Mn(3)CaO(4))(6+) cubane  0   *Bridged Compounds *Organometallic Compounds Calcium Manganese. Science. 2011 Aug 5;333(6043):733-6
uprolide D  0   *Bridged Compounds *Lactones. Org Lett. 2010 Oct 1;12(19):4328-31
alpha-santalone  0   *Bridged Compounds *Sesquiterpenes. Phytother Res 2010 Jul;24(7):1084-7
(5.5)(4,4')azobenzeno(1,5)naphthalenophane  0   *Azo Compounds *Bridged Compounds. Inorg Chem 2010 Jun 7;49(11):4765-7
KNT 63  0   *Bridged Compounds *Heterocyclic Compounds with 4 or More Rings. Bioorg Med Chem Lett 2010 Jan 1;20(1):121-4
nanolobatolide  0   *Bridged Compounds. Org Lett. 2009 Nov 5;11(21):5030-2
(2.2.1) hept-2'-en-2'-amino-N-azatricyclo (3.2.1.0(2,4)) octane  0   *Bridged Compounds *Cyclooctanes. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Jan;71(5):1749-55
helminthosporic acid  0   *Bridged Compounds. Molecules. 2009;14(1) (dup#1):160-73
NVP 995  0   *Bridged Compounds *Benzothiazoles. Anal Biochem 2009 Jan 1;384(1):166-9
NVP 231  0   *Bridged Compounds *Benzothiazoles. Anal Biochem 2009 Jan 1;384(1):166-9
deoxypukalide  0   *Bridged Compounds 4-Butyrolactone/*analogs & derivatives. Angew Chem Int Ed Engl 2008;47(38):7314-6
MBC94  0   *Bridged Compounds *Pyrazoles Ligands. Bioconjug Chem. 2008 May;19(5):988-92
longithorone C  0   *Bridged Compounds. Org Lett 2008 Jul 17;10(14):2927-30
isishippuric acid A  0   *Bridged Compounds *Dicarboxylic Acids. Biosci Biotechnol Biochem. 2008 Jun;72(6):1628-9
platensimide A  0   *Aminobutyric Acids *Bridged Compounds. Org Lett 2008 May 1;10(9):1699-702
plagiochin E  0   *Bridged Compounds *Stilbenes. Eur J Pharmacol 2008 Apr 14;584(1):66-71
gymnastatin R  0   *Bridged Compounds. J Nat Prod 2008 Mar;71(3):340-5
gymnastatin Q  0   *Bridged Compounds. J Nat Prod 2008 Mar;71(3):340-5
PF1270B  0   *Bridged Compounds *Heterocyclic Compounds, 3-Ring. J Antibiot (Tokyo). 2007 Nov;60(11):667-73
PF1270C  0   *Bridged Compounds *Heterocyclic Compounds, 3-Ring Ligands. J Antibiot (Tokyo). 2007 Nov;60(11):667-73
PF1270A  0   *Bridged Compounds *Heterocyclic Compounds, 3-Ring Ligands. J Antibiot (Tokyo). 2007 Nov;60(11):667-73
2',4'-BNA(NC)  0   *Bridged Compounds *Nucleotides. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1625-8
IEM 1913  0   *Bridged Compounds Putrescine/*analogs & derivatives Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors Receptors, AMPA/antagonists & inhibitors. Eksp Klin Farmakol 2007 Jul-Aug;70(4):15-9
bisbenzotetracyclo(6.2.2.2(3,6).0(2,7))tetradeca-4,9,11,13-tetraene  0   *Bridged Compounds *Naphthacenes. J Mol Model 2007 Dec;13(12):1215-20
decamethylcucurbit(5)uril  0   *Bridged Compounds *Imidazoles. Molecules 2007;12(7):1325-33
cucurbit(5)uril  0   *Bridged Compounds *Imidazoles. Molecules 2007;12(7):1325-33
8-phenylthiopaeonimetabolin I  0   *Bridged Compounds. Phytomedicine 2007 Aug;14(7-8):452-9
walsuronoid C  0   *Bridged Compounds *Limonins. Org Lett 2007 Jun 7;9(12):2353-6
walsuronoid B  0   *Bridged Compounds *Limonins. Org Lett 2007 Jun 7;9(12):2353-6
walsuronoid A  0   *Bridged Compounds *Limonins. Org Lett 2007 Jun 7;9(12):2353-6
stella-2,6-dione  0   *Bridged Compounds. J Comput Chem 2006 Nov 15;27(14):1703-22
stella-2,6-diene  0   *Bridged Compounds. J Comput Chem 2006 Nov 15;27(14):1703-22
EDP 420  0   *Bridged Compounds *Macrolides. Antimicrob Agents Chemother 2007 May;51(5):1666-70
1,3-dehydrotricyclo(3.3.0.0(3,7))octane  0   *Bridged Compounds. Chemistry 2007;13(5):1522-32
1,3-diiodotricyclo(3.3.0.0(3,7))octane  0   *Bridged Compounds. Chemistry 2007;13(5):1522-32
2,5-methano-bridged (2.2.1)propellane  0   *Bridged Compounds. Chemistry 2007;13(5):1522-32
triquinane  0   *Bridged Compounds *Sesquiterpenes. J Org Chem. 2006 Jun 9;71(12):4411-7
1-epi-pathylactone A  0   *Bridged Compounds *Lactones. Org Lett. 2007 Mar 29;9(7):1351-4
parvineostemonine  0   *Bridged Compounds *Spiro Compounds. Org Lett. 2007 Mar 29;9(7):1275-8
3-azabicyclo(3.3.1)nonane-2,4-dione  0   *Aza Compounds *Bridged Compounds. J Am Chem Soc. 2007 Mar 28;129(12):3649-57
octahedrane  0   *Aza Compounds *Bridged Compounds. J Am Chem Soc. 2006 Dec 27;128(51):16508-9
2,11-diaza(3.3)paracyclophane  0   *Aza Compounds *Bridged Compounds. J Am Chem Soc. 2006 Dec 27;128(51):16508-9
11-O-debenzoyltashironin  0   *Bridged Compounds. J Am Chem Soc. 2006 Dec 27;128(51):16440-1
macarangioside C  0   *Bridged Compounds *Glucosides. Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1403-7
macarangioside B  0   *Bridged Compounds *Glucosides. Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1403-7
gymnastatin G  0   *Bridged Compounds. J Nat Prod 2006 Oct;69(10):1384-8
gymnastatin F  0   *Bridged Compounds. J Nat Prod 2006 Oct;69(10):1384-8
quadricyclane  0   *Bridged Compounds. Angew Chem Int Ed Engl. 2005 May 20;44(21):3275-9
9-hydroxymethylanthrance  0   *Anthracenes *Bridged Compounds. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2005 Dec 22;109(50):24203-10
modhephene  0   *Bridged Compounds *Sesquiterpenes. Org Biomol Chem. 2005 Jan 21;3(2):340-7
gambogin  0   *Alkenes *Bridged Compounds. Angew Chem Int Ed Engl. 2005 Jan 21;44(5):756-61
4-amino-(D3)-trishomocubane-4-carboxylic acid  0   *Amino Acids *Bridged Compounds. Biopolymers 2006 Apr 5;81(5):339-49
paeoniflorin-4-ethyl ether  0   *Glucosides *Bridged Compounds *Benzoic Acids. Zhongguo Zhong Yao Za Zhi 2005 May;30(10):759-61
2-methylresorcinarene-5,11,17,23-C-tetraethylsulfonate  0   *Bridged Compounds *Sulfonic Acids. Electrophoresis 2006 Feb;27(4):842-51
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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