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Busulfan

More information in Books or onNLM PubMed
Definition: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.     
Pharmacological Action Alkylating Agents; Antineoplastic Agents, Alkylating; Immunosuppressive Agents; Myeloablative Agonists 		Other names Busulphan; Wellcome, Busulfan; Busulfan Wellcome Brand; Busulfan Orphan Brand; Busulfan GlaxoSmithKline Brand; n-Butane-1,3-di(methylsulfonate); Wellcome Brand of Busulfan; Orphan Brand of Busulfan; Myl+¬ran; Myleran; Mylecytan; Myelosan; Glyzophrol; GlaxoSmithKline Brand of Busulfan; Glaxo Wellcome Brand of Busulfan; Busulfex; Busulfan WellcomeDrugs* : MYLERAN; BUSULFEX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BuCEt protocol  0   *Antineoplastic Combined Chemotherapy Protocols Busulfan Cyclophosphamide Etoposide. Acta Haematol 2000;104(2-3):144-7
BUCY-2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Busulfan Cyclophosphamide. J Clin Oncol 1991;9(10):1881
1,4-butanediol diisethionate  81171-23-5   Busulfan/*analogs & derivatives. Jpn J Cancer Res 1988;79(9):1048
treosulfan  299-75-2 (S-(R*,R*))- 1,2,3,4-butanetetrol, 1,4-dimethanesulfonate  Busulfan/*analogs & derivatives.
Pharma Action Antineoplastic Agents, Alkylating 		Cancer 1980;45(1):19; Lancet 1(8107):106;1979; Lancet 2(8101):1207;1978
4-methanesulfonyloxybutanol  42729-95-3 1,4-Butanediol, monomethanesulfonate  Busulfan/*analogs & derivatives. J Pharm Sci 62(6):1007;1973
dimethylmyleran  55-93-6 2,5-hexanediol dimethanesulfonate  Busulfan/*analogs & derivatives. Can J Biochem 50(10):1074;1972; Eur J Cancer 13(12):1411;1977; Exp Hematol 3(5):19;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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