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Calcifediol

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Definition: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.  deficiency: coordinate CALCIFEDIOL /defic (IM) with VITAMIN D DEFICIENCY (IM)   
Pharmacological Action Bone Density Conservation Agents; Vitamins 		Other names 25-Hydroxyvitamin D 3; 25-Hydroxycholecalciferol; Calcifediol Organon Brand; Calcifediol Faes Brand; Calcifediol Aventis Brand; 25 Hydroxyvitamin D3; 25 Hydroxyvitamin D 3; 25 Hydroxycholecalciferol; Organon Brand of Calcifediol; Hidroferol; Faes Brand of Calcifediol; Dedrogyl; Calderol; Calcifediol, (3 beta,5E,7E)-Isomer; Calcifediol, (3 alpha,5Z,7E)-Isomer; Calcidiol; Aventis Brand of Calcifediol; 25-Hydroxyvitamin D3Drugs* : CALDEROL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-bromoacetoxycalcidiol  0   Calcifediol/*analogs & derivatives. Chem Biol Drug Des 2007 Oct;70(4):302-10
26,26,26,27,27,27-hexadeutero-25-hydroxyvitamin D(3)  0   Calcifediol/*analogs & derivatives. J Org Chem. 2009 Jul 3;74(13):4782-6
1alpha-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxyvitamin D3  0   Calcifediol/*analogs & derivatives. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2)203-11
20-hydroxyvitamin D3  0   Calcifediol/*analogs & derivatives. Proc Natl Acad Sci U S A 2003 Dec 9;100(25):14754-9
25-hydroxyvitamin D3-bromoacetate  0   Calcifediol/*analogs & derivatives. Arch Biochem Biophys 1996 Sep 1;333(1):139-44
3'-O-aminopropyl-25-hydroxyvitamin D3  0   Calcifediol/*analogs & derivatives. Protein Expr Purif 1995 Apr;6(2):185-8
A-homo-3-deoxy-3,3-dimethyl-2,4-dioxa-25-hydroxyvitamin D3  135821-90-8   Calcifediol/*analogs & derivatives. J Steroid Biochem Mol Biol 1991;38(6):775
2-oxa-3-deoxy-25-hydroxyvitamin D3  113490-39-4   Calcifediol/*analogs & derivatives. J Steroid Biochem Mol Biol 1991;38(6):775
2-nor-1,3-seco-1,25-dihydroxyvitamin D3  113490-37-2   Calcifediol/*analogs & derivatives. J Steroid Biochem Mol Biol 1991;38(6):775
25-hydroxyvitamin D3 3'-(N-(4-azido-2-nitrophenyl)amino)propyl ether  133191-08-9   *Azides Calcifediol/*analogs & derivatives. Biochemistry 1991;30(19):4809
24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3  106647-61-4   Calcifediol/*analogs & derivatives. J Med Chem 1990;33(2):480
25-hydroxy-26,27-dimethylvitamin D3  116925-40-7   Calcifediol/*analogs & derivatives. J Steroid Biochem 1988;31(2):147
3-deoxy-3-azido-25-hydroxyvitamin D3  108345-00-2   *Azides Calcifediol/*analogs & derivatives. Biochemistry 1987;26(13):3957
25-hydroxyvitamin D3 3-(N-(4-azido-2-nitrophenyl)glycinate)  101396-04-7   *Azides Calcifediol/*analogs & derivatives. Biochemistry 198625(17):4729
25-hydroxyvitamin D3 3-sulfate ester  99447-30-0   Calcifediol/*analogs & derivatives. FEBS Lett 1985;191(2):171
25-hydroxy-6,19-epoxyvitamin D3  96999-68-7   Calcifediol/*analogs & derivatives. J Med Chem 1985;28(9):1153
19,25-dihydroxy-6,19-dihydro-6,19-epoxyvitamin D3  96999-67-6   Calcifediol/*analogs & derivatives. J Med Chem 1985;28(9):1153
25-hydroxy-6,19-dihydro-6,19-ethanovitamin D3  96616-70-5   Calcifediol/*analogs & derivatives. J Med Chem 1985;28(9):1148
1-25-dihydroxy-23,23-difluorovitamin D3  98040-59-6   Calcifediol/*analogs & derivatives. Arch Biochem Biophys 1985;241(1):173
23,23-difluoro-25-hydroxyvitamin D3  95826-03-2   Calcifediol/*analogs & derivatives. Arch Biochem Biophys 1985;241(1):173
1-fluoro-25-hydroxyvitamin D3  74041-09-1   Calcifediol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1984;32(9):3525
10-keto-25-hydroxyvitamin D3  86852-07-5 19-Nor-9,10-secocholesta-5,7-dien-4-one, 1,25-dihydroxy-, (1alpha,5Z,7E)  Calcifediol/*analogs & derivatives. Arch Biochem Biophys 1985;236(2):555
calcifediol lactol  83136-06-5 9,10-Secocholesta-5,7,10(19)-triene-3,25,26-triol, 23,26-epoxy-, (3beta,5Z,7E,23S,25R)  Calcifediol/*analogs & derivatives. J Biol Chem 1984;259(2):884
19-nor-10-keto-25-hydroxyvitamin D3  85925-90-2   Calcifediol/*analogs & derivatives. Biochemistry 1983;22(15):3636
25-hydroxy-26,26,26,27,27,27-hexafluorovitamin D3  75303-43-4   Calcifediol/*analogs & derivatives. Arch Biochem Biophys 1982;218(1):134
23-dehydro-25-hydroxyvitamin D3  80463-19-0 9,10-Secocholesta-5,7,10(19),23-tetraene-3,25-diol, (3beta,5Z,7E)  Calcifediol/*analogs & derivatives. Biochemistry 1981;20(26):7385
25-hydroxy-24-oxocholecalciferol  74886-61-6 9,10-Secocholesta-5,7,10(19)-trien-24-one, 3,25-dihydroxy-, (3beta,5Z,7E)  Calcifediol/*analogs & derivatives. Biochem Biophys Res Commun 1980;95(1):177
calcifediol lactone  71302-34-6 9,10-Secocholesta-5,7,10(19)-trien-26-oic acid, 3,23,25-trihydroxy-, gamma-lactone, (3beta,5Z,7E)  Calcifediol/*analogs & derivatives. Biochem Biophys Res Commun 1980;95(2):520; Biochem Biophys Res Commun 89(1):286;1979; Biochemistry 1979;18(22):4775
24,24-difluoro-25-hydroxyvitamin D3  71603-41-3 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, 24,24-difluoro-, (3beta,5Z,7E)  Calcifediol/*analogs & derivatives. J Biol Chem 254(15):7163;1979
3-deoxy-25-hydroxyvitamin D3  0   Calcifediol/*analogs & derivatives. FEBS Lett 97(2):241;1979
24-nor-25-hydroxyvitamin D(3)  36415-31-3   Calcifediol/*analogs & derivatives. Biochem Biophys Res Commun 67(2):797;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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