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Calcitriol

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Definition: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.  deficiency: coordinate CALCITRIOL /defic (IM) with VITAMIN D DEFICIENCY (IM)   
Pharmacological Action Bone Density Conservation Agents; Calcium Channel Agonists; Vitamins
See Also Receptors, Calcitriol 		Other names 1,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol; 1 alpha,25-Dihydroxyvitamin D3; 1 alpha,25-Dihydroxycholecalciferol; alpha,25-Dihydroxyvitamin D3, 1; MC 1288; KyraMed, Calcitriol; Hoffmann La Roche Brand of Calcitriol; D3, 1,25-dihydroxy-20-epi-Vitamin; D3, 1,25-Dihydroxyvitamin; D3, 1 alpha,25-Dihydroxyvitamin; CalcitriolNefro; Calcitriol Roche Brand; Calcitriol RenaCare Brand; Calcitriol Nefro; Calcitriol Medice Brand; Calcitriol Leo Brand; Calcitriol KyraMed Brand; Calcitriol Jenapharm Brand; Calcitriol Gry BrandDrugs* : VECTICAL; CALCIJEX; ROCALTROL; CALCITRIOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol  0   Calcitriol/*analogs & derivatives. Br J Pharmacol. 2011 Sep;164(2b):551-60.
2-methyl-19-nor-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. Clin Exp Immunol. 2011 Dec;166(3):325-32.
1alpha-hydroxy-3-deoxyvitamin D3  0   Calcitriol/*analogs & derivatives. J Org Chem. 2010 Oct 15;75(20):6820-9
19-nor-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. J Med Chem 2010 Dec 23;53(24):8642-9
N-(2-aminophenyl)-6-(4-(2-(3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-4-methylhepta-2,4-dienamide  0   *Anilides Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7461-5
1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol  0   Calcitriol/*analogs & derivatives. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):408-12
22-butyl-1,24-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):146-50
25-hydroxy-2-methylene-19-norvitamin D3  0   Calcitriol/*analogs & derivatives. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):51-5
1,25-dihydroxy-6-methylvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):29-33
24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-24-chloro-1,3-diol  0   Calcitriol/*analogs & derivatives. Anticancer Drugs 2010 Jul;21(6):609-18
2-methyl-20,23-epoxymethano-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. J Med Chem 2010 Feb 11;53(3):1159-71
1,25-dihydroxyvitamin D3-11-hydroxy-(2)-bromoacetate  0   Calcitriol/*analogs & derivatives. Bioorg Chem 2009 Apr;37(2):57-63
1,25-dihydroxyvitamin D3-1-(2)-bromoacetate  0   Calcitriol/*analogs & derivatives. Bioorg Chem 2009 Apr;37(2):57-63
1,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3  0   Calcitriol/*analogs & derivatives. J Med Chem 2009 Apr 23;52(8):2204-13
1,25-dihydroxy-16-ene-20-cyclopropylvitamin D3  0   Calcitriol/*analogs & derivatives. J Med Chem 2009 Apr 23;52(8):2204-13
1,25-(dihydroxy-21-(3-hydorxy-3-methyl-butyl)-nor-cholecalciferol)  0   Calcitriol/*analogs & derivatives. Regul Toxicol Pharmacol 2008 Dec;52(3):332-41
triciferol  0   Calcitriol/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8250-5
(25S)-26-adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3  0   Adamantane/*analogs & derivatives Calcitriol/*analogs & derivatives. Arch Biochem Biophys 2007 Apr 15;460(2):240-53
2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. Bone 2007 Feb;40(2):293-304
22-butyl-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Med Chem 2007 Mar 8;50(5):932-9
22-ethyl-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Med Chem 2007 Mar 8;50(5):932-9
Maxmarvil  0   *Calcitriol *Alendronate Drug Combinations. Osteoporos Int 2006 Dec;17(12):1801-7
KSP-BCS-1alpha-CHF2-20-epi-22-oxa-bishomo-26-OH compound  0   Calcitriol/*analogs & derivatives. J Med Chem 2006 Dec 14;49(25):7513-7
KSP-BCS-1alphaCHF2-1624F2-2 compound  0   Calcitriol/*analogs & derivatives. J Med Chem 2006 Dec 14;49(25):7513-7
betamethasone dipropionate, calcipotriol drug combination  0   Betamethasone/*analogs & derivatives Calcitriol/*analogs & derivatives Drug Combinations. Dermatology 2006;213(4):319-26
1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)-23-yne-26,27-hexafluorocholecalciferol  0   Calcitriol/*analogs & derivatives. Biochem Pharmacol 2006 Jul 28;72(3):332-43
Ro43 83582  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Biol Chem 2006 Apr 14;281(15):10516-26
DLAM-1P compound  0   *Lactams Calcitriol/*analogs & derivatives Calcitriol/antagonists & inhibitors. Bioorg Med Chem Lett 2004 May 17;14(10):2579-83
20(17-12)-abeo-1,25-dihydroxy-24-dihomo-21-norvitamin D3  0   Calcitriol/*analogs & derivatives. J Med Chem 2006 Mar 9;49(5):1509-16
BXL628  0   Calcitriol/*analogs & derivatives. Eur J Endocrinol 2004 Apr;150(4);591-603
2,2-dimethyl-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. Org Biomol Chem. 2003 Jun 7;1(11):1863-9
ZK 191784  0   Calcitriol/*analogs & derivatives. J Invest Dermatol 2002 Dec;119(6):1434-42
2-methylene-1,25-dihydroxy-19-norvitamin D3  0   Calcitriol/*analogs & derivatives. Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13487-91
1,25-dihydroxy-5,6-16-ene-vitamin D3  0   Calcitriol/*analogs & derivatives. J Cell Physiol 2002 May;191(2):198-207
JK 1626-2  0   Calcitriol/*analogs & derivatives. J Biol Chem 2001 Aug 3;276(31):29148-56
2-fluoro-19-nor-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives Stereoisomerism. Chirality 2001 Jul;13(7):366-71
21-(3-methyl-3-hydroxybutyl)-19-norvitamin D3  0   Calcitriol/*analogs & derivatives. Blood 2001 Apr 15;97(8):2427-33
ZK 168281  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. Chem Biol 2000 Nov;7(11):885-94
1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)  0   Calcitriol/*analogs & derivatives Ligands. J Med Chem 2000 Jul 13;43(14):2719-30
ZK159222  0   Calcitriol/*analogs & derivatives. J Biol Chem 2000 Jun 2;275(22):16506-12
1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3  0   Cholecalciferol/*analogs & derivatives Calcitriol. Biochem Biophys Res Commun 2000 Apr 21;270(3):701-8
TEI 9647  0   Calcitriol/*analogs & derivatives Stereoisomerism. FEBS Lett 1999 Oct 29;460(2):297-302
CB 1267  0   Calcitriol. Prostate 1999 Aug 1;40(3):141-9
GS 1500  0   Calcitriol. Br J Pharmacol 1999 Apr;126(8):1815-23
MC 1627  0   Calcitriol/*analogs & derivatives. J Biol Chem 1999 Jun 11;274(24):16838-45
1,24-dihydroxy-25-nitrovitamin D3  0   *Nitro Compounds Calcitriol/*analogs & derivatives. Bioorg Med Chem Lett 1999 Feb 8;9(3):381-4
24,24-difluoro-1,23,25-trihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1998 Dec;46(12):1932-5
1-hydroxy-19-norvitamin D3  0   Calcitriol/*analogs & derivatives. Br Poult Sci 1998 Jul;39(3):408-12
JK 1624F2-1  0   Calcitriol/*analogs & derivatives Stereoisomerism. J Med Chem 1998 Jul 30;41(16):3008-14
QW 1624F2-1  0   Calcitriol/*analogs & derivatives Stereoisomerism. J Med Chem 1998 Jul 30;41(16):3008-14
2-chloro-1-epicalcitriol  0   Calcitriol/*analogs & derivatives Stereoisomerism. Steroids 1998 Jan;63(1):28-36
PRI 1901  0   Calcitriol/*analogs & derivatives. Steroids 1997 Jul;62(7):546-53
PRI 2168  0   Calcitriol/*analogs & derivatives. Steroids 1997 Jul;62(7):546-53
ZXY 1106  0   Calcitriol/*analogs & derivatives. Transplant Proc 1997 Jun;29(4):2156-7
11-hemiglutaryloxy-1,15-dihydroxyvitamin D3  0   *Glutarates Calcitriol/*analogs & derivatives. Anal Biochem 1997 Jan 15;244(2):374-83
1,25-dihydroxyvitamin D3-3-bromoacetate  0   Calcitriol/*analogs & derivatives. J Cell Biochem 1996 Dec 1;63(3):302-10
ZK 157202  0   Calcitriol/*analogs & derivatives. J Cell Biochem 1996 Nov 1;63(2):199-206
ZK 161422  0   Calcitriol/*analogs & derivatives. J Cell Biochem 1996 Nov 1;63(2):199-206
KH 1266  0   Calcitriol/*analogs & derivatives. J Clin Invest 1997 Jan 15;99(2):349-60
GS 1725  0   Calcitriol/*analogs & derivatives. Nephrol Dial Transplant 1996 Sep;11(9):1781-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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