Calpain (definition)

encyclopedia of medical concepts

ψ
ψ

Calpain

More information in Books or on

Definition: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.

/biosyn /physiol permitted

Other names Calcium-Dependent Neutral Proteinase; Calcium-Activated Neutral Protease; Proteinase, Calcium-Dependent Neutral; Proteinase, Calcium-Activated Neutral; Protease, Calcium-Dependent Neutral; Protease, Calcium-Activated Neutral; Protease, Calcium-Activated; Protease, Ca2+-Activated; Neutral Proteinase, Calcium-Dependent; Neutral Proteinase, Calcium-Activated; Neutral Protease, Calcium-Dependent; Neutral Protease, Calcium-Activated; II, Calpain; I, Calpain; Calcium Dependent Neutral Proteinase; Calcium Dependent Neutral Protease; Calcium Activated Protease; Calcium Activated Neutral Proteinase; Calcium Activated Neutral Protease; Ca2+ Activated Protease

Substance	CAS Registry & name	Categories	Source
Capn2 protein, mouse	0	*Calpain.	Am J Physiol Lung Cell Mol Physiol. 2012 Feb;302(4):L370-9
CAPN2 protein, human	EC 3.4.22.-	*Calpain.	Przegl Lek. 2011;68(5):258-62
calpain A, Drosophila	EC 3.4.22.-	Calpain Drosophila Proteins.	Mol Cell Biol. 1995 Feb;15(2):824-34.
calpain 8 protein, xenopus	EC 3.4.22.-	Calpain Xenopus Proteins.	Dev Cell. 2011 Feb 15;20(2):256-63
3-(benzyloxycarbonylleucylamino)-N-(3-(6-amino-9H-purin-9-yl)propyl)-2-oxopentanamide	0	Dipeptides Adenine/analogs & derivatives Calpain/antagonists & inhibitors.	J Med Chem 2010 Sep 9;53(17):6326-36
3-(benzyloxycarbonylleucylamino)-N-(3-(4-methylpiperazin-1-yl)propyl)-2-oxopentanamide	0	Dipeptides Piperazines Calpain/antagonists & inhibitors.	J Med Chem 2008 Sep 11;51(17):5264-70
CEP-3453	0	*Dipeptides Calpain/antagonists & inhibitors.	Crit Care Med. 2008 Nov;36(11 Suppl):S481-5
benzyloxycarbonyl-leucyl-glucyl-tyrosine fluoromethyl ketone	0	*Oligopeptides Calpain/antagonists & inhibitors.	Dig Dis Sci 2009 Nov;54(11):2357-61
B27-HYD peptide	0	Calpain Peptide Fragments.	Biochem Biophys Res Commun 2009 Jul 17;385(1):94-9
5-formyl-pyrrole-2-carboxylic acid (1-(1-formyl-3-methyl-butylcarbamoyl)-2-methyl-propyl)amide	0	Dipeptides Pyrroles Calpain/antagonists & inhibitors.	Clin Experiment Ophthalmol 2008 Dec;36(9):852-60
CALPx11 protein, Trypanosoma cruzi	EC 3.4.22.-	Calpain Protozoan Proteins.	Mem Inst Oswaldo Cruz 2008 Sep;103(6):598-601
epicatechin 5-gallate	0	Catechin/*analogs & derivatives Calpain/antagonists & inhibitors.	Fitoterapia 2009 Jan;80(1):73-6
CAPNS1 protein, human	EC 3.4.22.52	*Calpain.	Cell Cycle 2007 Oct 15;6(20):2579-80
CAPN9 protein, human	EC 3.4.22.4	*Calpain.	J Mol Biol 2007 Feb 9;366(1):216-29
calpain 2, human	EC 3.4.22.4	*Calpain.	Oncogene 2006 Oct 21;25(42):5726-40
SNJ 1715	0	Thiourea/*analogs & derivatives Calpain/antagonists & inhibitors.	J Med Chem 2006 Jun 29;49(13):3926-32
DEK1 protein, Arabidopsis	EC 3.4.22.4	Calpain Arabidopsis Proteins.	Planta 2005 Jun;221(3):339-51
calpastat	0	*Recombinant Fusion Proteins Calpain/antagonists & inhibitors.	J Biol Chem 1999 Dec 17;274(51):36321-7
Capn12 protein, mouse	EC 3.4.22.-	*Calpain.
A-705253	0	*Benzamides Calpain/antagonists & inhibitors.	Biol Chem 2004 Nov;385(11):1077-82
Capn5 protein, human	EC 3.4.22.17	*Calpain.	Biochem Biophys Res Commun 2004 Nov 5;324(1):46-51
calpain 5, rat	EC 3.4.22.17	*Calpain.	Biochem Biophys Res Commun 2004 Nov 5;324(1):46-51
Capn3 protein, mouse	EC 3.4.22.-	Calpain Muscle Proteins.
Capn3 protein, rat	EC 3.4.22.-	Calpain Isoenzymes *Muscle Proteins.
Pdcd6 protein, mouse	0	Calcium-Binding Proteins Apoptosis Regulatory Proteins Calpain Apoptosis.
A 705239	0	*Benzamides Calpain/antagonists & inhibitors.	J Med Chem 2003 Jun 5;46(12):2404-12
Capn11 protein, mouse	EC 3.4.22.-	*Calpain.
Capn7 protein, mouse	EC 3.4.22.-	*Calpain.
CalpB protein, Drosophila	EC 3.4.22.17	Calpain Drosophila Proteins.	Biochem J 2004 Mar 1;378(Pt 2):299-305
CAPN1 protein, Bos taurus	0	*Calpain.
CAPN1 protein, human	0	*Calpain.
calpain C, Drosophila	EC 3.4.22.17	Calpain Drosophila Proteins.	Biochem Biophys Res Commun 2003 Mar 28;303(1):343-9
mu-calpain	EC 3.4.22.-	*Calpain.	Biol Chem 2001 May;382(5):767-76
m-calpain proenzyme	EC 3.4.22.-	Calpain Protein Precursors.	Biol Chem 2001 May;382(5):767-76
m-calpain	EC 3.4.22.-	*Calpain.	Biol Chem 2001 May;382(5):753-66
XCL-2 calpain	EC 3.4.22.-	*Calpain.	Dev Growth Differ 2001 Oct;43(5):563-71
CAP5.5 protein, Trypanosoma brucei	EC 3.4.22.-	Calpain Protozoan Proteins.	Mol Biochem Parasitol 2001 Aug;116(1):25-34
1-(2-benzothienylcarbonyl)piperidin-4-ylcarbonyl-phenylalaninamide	0	*Oligopeptides Calpain/antagonists & inhibitors.	Bioorg Med Chem Lett 2000 Oct 2;10(19):2187-91
1-(2-naphthylcarbonyl)piperidin-4-ylcarbonyl-phenylalaninamide	0	*Oligopeptides Calpain/antagonists & inhibitors.	Bioorg Med Chem Lett 2000 Oct 2;10(19):2187-91
CAPN12 protein, human	EC 3.4.22.-	*Calpain.	Genomics. 2000 Sep 1;68(2):152-60
calpain 10	EC 3.4.22.-	*Calpain.	Nat Genet 2000 Oct;26(2):163-75
Capns1 protein, mouse	EC 3.4.22.-	*Calpain.	Mol Cell Biol 2000 Jun;20(12):4474-81
acetyl-leucyl-leucyl-normethional	0	*Oligopeptides Calpain/antagonists & inhibitors.	J Biochem (Tokyo) 2000 Feb;127(2):297-305
Capn5 protein, mouse	EC 3.4.22.-	*Calpain.	Mech Dev 1999 Dec;89(1-2):201-9
Capn6 protein, mouse	EC 3.4.22.-	*Calpain.	Mech Dev 1999 Dec;89(1-2):201-9
MDL 104903	0	Oxazoles Carbamates Calpain.	Bioorg Med Chem Lett 1999 Aug 16;9(16):2365-70
CAPN11 protein, human	EC 3.4.22.-	*Calpain.	Genomics 1999 Jul 15;59(2):243-7
Capn8 protein, mouse	EC 3.4.22.-	*Calpain.	Biochem Biophys Res Commun 1999 Jul 14;260(3):671-5
calpain Lp82	EC 3.4.22.-	*Calpain.	Exp Eye Res 1999 Apr;68(4):447-56
Capn7 protein, human	EC 3.4.22.-	*Calpain.	Mamm Genome 1999 Mar;10(3):318-21
PD 151746	0	*Acrylates Calpain/antagonists & inhibitors.	J Cell Physiol 1999 Mar;178(3):311-9
SOLH protein, human	0	*Calpain Zinc Fingers.	Genomics 1998 Jul 15;51(2):197-206
Capn1 protein, mouse	0	*Calpain.	Mamm Genome 1998 May;9(5):388-9
N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal	0	*Dipeptides Calpain/antagonists & inhibitors.	Biochim Biophys Acta 1997 Oct 24;1361(3):304-12
CAPN3 protein, human	EC 3.4.22.-	Calpain Muscle Proteins.	J Anim Sci 1998 Mar;76(3):918-9; Mamm Genome 1996 May;7(5):377-9; Neurology 2001 Mar 13;56(5)
TRA-3 protein, C elegans	0	*Caenorhabditis elegans Proteins Calpain.	EMBO J 1996 Sep 2;15(17):4477-84
mu-calpain proenzyme	EC 3.4.22.-	Calpain Enzyme Precursors.	Brain Res 1995 Oct 30;697(1-2):179-86
PDCD6 protein, human	0	Calcium-Binding Proteins Apoptosis Regulatory Proteins Calpain Apoptosis.	Science 1996 Jan 26;271(5248):521-5
phevalin	0	*Pyrazines Calpain/antagonists & inhibitors.	J Antibiot (Tokyo) 1995 Oct;48(10):1165-7
3,6-bis(4-hydroxyphenylmethyl)-1,4-dimethyl-2,5-diketopiperazine	0	Piperazines Tyrosine/analogs & derivatives Calpain/antagonists & inhibitors.	J Antibiot (Tokyo) 1994 Nov;47(11):1195-201

more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link

Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy