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Camptothecin

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Definition: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.     
Pharmacological Action Antineoplastic Agents, Phytogenic; Topoisomerase I Inhibitors
Examples Topotecan 		Other names Camptothecine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ONCOFID-S  0   Camptothecin/*analogs & derivatives Hyaluronic Acid/*analogs & derivatives. Curr Cancer Drug Targets 2011 Jun;11(5):572-85
7-ethyl-14-aminocamptothecin  0   Camptothecin/*analogs & derivatives. J Med Chem 2011 Mar 24;54(6):1715-23
7-butyl-10-amino-camptothecin-beta-alanine-lysine  0   *Dipeptides Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I. Cancer Chemother Pharmacol 2011 Apr;67(4):855-65
7-butyl-10-amino-camptothecin  0   Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I. Cancer Chemother Pharmacol 2011 Apr;67(4):855-65
TLC 388  0   Camptothecin/*analogs & derivatives. Anticancer Res 2010 Mar;30(3):937-44
7-tert-butyldimethylsilyl-10-hydroxyhomocamptothecin  0   Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I/antagonists & inhibitors. Pharmacol Res 2010 Feb;61(2):108-15
XMT 1001  0   *Polymers Camptothecin/*analogs & derivatives Acetals. Adv Drug Deliv Rev 2009 Nov 12;61(13):1193-202
ST 1698  0   Camptothecin/*analogs & derivatives. J Pharm Biomed Anal 2009 Oct 15;50(3):507-14
IT-101  0   *Camptothecin *Cyclodextrins. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11394-9
CH 0793076  0   Camptothecin/*analogs & derivatives. Bioorg Med Chem Lett 2009 Apr 1;19(7):2018-21
7-((3-piperidyl)-1-propynyl)camptothecin  0   Camptothecin/*analogs & derivatives. Invest New Drugs 2008 Dec;26(6):517-24
10-(2-pyrazolylethoxy)camptothecin  0   Camptothecin/*analogs & derivatives. Chem Biol Interact 2008 Nov 25;176(2-3):165-72
camptothecin, C20-propionate ester  0   Camptothecin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2008 May 1;867(1):84-9
ST 1968  0   Camptothecin/*analogs & derivatives. Biochem Pharmacol 2007 Mar 1;73(5):656-64
pumiloside  0   Camptothecin/*analogs & derivatives. Phytochemistry 1995 May;39(2):383-5
isocamptothecin B  0   Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I/antagonists & inhibitors. Exp Dermatol 2008 Jun;17(6):530-6
isocamptothecin A  0   Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I/antagonists & inhibitors. Exp Dermatol 2008 Jun;17(6):530-6
16a-thiocamptothecin  0   *Thiones Camptothecin/*analogs & derivatives. J Med Chem 2008 May 22;51(10):3040-4
DTS-108  0   *Peptides Camptothecin/*analogs & derivatives Prodrugs. Clin Cancer Res 2008 Apr 1;14(7):2145-53
EZN-2208  0   *Polyethylene Glycols Camptothecin/*analogs & derivatives. Clin Cancer Res 2008 Mar 15;14(6):1888-96
4-deshydroxy-4-(N-methyl-(2-(((5-nitrofur-2-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin  0   *Furans Camptothecin/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2007;(51):229-30
4-deshydroxy-4-(N-methyl-(2-(((5-methoxy-1,2-dimethyl-4,7-dioxoindol-3-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin  0   *Quinones Camptothecin/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2007;(51):229-30
hydroxycamptothecinum  0   Camptothecin/*analogs & derivatives. J Clin Lab Anal 2007;21(6):356-62
CPT-10-B  0   Camptothecin/*analogs & derivatives. Bioorg Med Chem. 2007 Dec 15;15(24):7590-8
polyglutamate camptothecin  0   Camptothecin/*analogs & derivatives Polyglutamic Acid/*analogs & derivatives. Clin Cancer Res 2007 Oct 1;13(19):5855-61
CPT417  0   Camptothecin/*analogs & derivatives. Anticancer Res. 2007 Sep-Oct;27(5A):3173-8
S 38809  0   *Dioxoles Camptothecin/*analogs & derivatives DNA Topoisomerases, Type I/antagonists & inhibitors. Mol Pharmacol 2007 Aug;72(2):311-9
maleimidohexyl-arginyl-arginyl-alanyl-leucyl-alanyl-leucyl-alanyl-camptothecin  0   *Oligopeptides Camptothecin/*analogs & derivatives. Bioconjug Chem 2007 May-Jun;18(3):702-16
chimmitecan  0   Camptothecin/*analogs & derivatives. Clin Cancer Res 2007 Feb 15;13(4):1298-307
capecitabine-irinotecan combination  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Deoxycytidine/analogs & derivatives Fluorouracil/analogs & derivatives. Br J Cancer 2007 May 21;96(10):1514-9
10,11-methylenedioxy-14-azacamptothecin  0   Camptothecin/*analogs & derivatives. Org Lett 2006 Aug 3;8(16):3513-6
JF-10-81  0   *Camptothecin *Somatostatin. Cancer Lett 2007 Feb 8;246(1-2):157-66
ST 1976  0   Camptothecin/*analogs & derivatives. Biochem Pharmacol 2007 Mar 1;73(5):656-64
poly(ethylene glycol)-camptothecin conjugate  0   *Polyethylene Glycols Camptothecin/*analogs & derivatives. J Control Release 2005 Dec 10;110(1):90-102
5-aminocamptothecin  0   Camptothecin/*analogs & derivatives. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6082-5
IDN5174  0   Camptothecin/*analogs & derivatives. Cancer Res 2006 Nov 15;66(22):10976-82
NSC606985  0   Camptothecin/*analogs & derivatives. Leukemia 2006 Jun;20(6):987-93
10-methoxy-9-nitrocamptothecin  0   Camptothecin/*analogs & derivatives. Mol Cancer Ther 2006 Apr;5(4):962-8
BMS 422461  0   Camptothecin/*analogs & derivatives. Cancer Chemother Pharmacol 2006 Jul;58(1):73-85
BMS 286309  0   Camptothecin/*analogs & derivatives. Cancer Chemother Pharmacol 2006 Jul;58(1):73-85
FOLFOXIRI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Camptothecin/analogs & derivatives Leucovorin Organoplatinum Compounds. Br J Cancer 2006 Mar 27;94(6):798-805
DHA-HCPT conjugate  0   *Docosahexaenoic Acids Camptothecin/*analogs & derivatives. Bioorg Med Chem 2005 Oct 1;13(19):5592-9
20-fluorocamptothecin  0   Camptothecin/*analogs & derivatives. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4736-40
glycyl-DX-8951  0   Camptothecin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25;818(2):249-56
14-azacamptothecin  0   Camptothecin/*analogs & derivatives. J Am Chem Soc 2005 Jan 26;127(3):838-9
camptothecin-20-glycinate ester  0   Camptothecin/*analogs & derivatives Glycine/*analogs & derivatives. J Pharm Biomed Anal 2004 Sep 3;35(5):1113-25
DRF-1042  0   Camptothecin/*analogs & derivatives. Biomed Chromatogr 2003 Sep;17(6):385-90
monomethoxypolyethylene glycol-carbonyl-glycyl-leucyl-phenylalanyl-glycyl-10-amino-7-ethylcamptothecin  0   *Oligopeptides Camptothecin/*analogs & derivatives. J Med Chem 2004 Feb 26;47(5):1280-9
10-amino-7-ethylcamptothecin  0   Camptothecin/*analogs & derivatives. J Med Chem 2004 Feb 26;47(5):1280-9
IROX protocol  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Organoplatinum Compounds. J Clin Oncol 2004 Jan 1;22(1):23-30
IFL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Leucovorin Fluorouracil. J Clin Oncol 2004 Jan 1;22(1):23-30
7-ethyl-10-hydroxycamptothecin acetic acid  0   Camptothecin/*analogs & derivatives. Nucleic Acids Res 2003 Jul 15;31(14):4031-40
9-aminocamptothecin glucuronide  0   *Glucuronides Camptothecin/*analogs & derivatives. Br J Cancer 2002 May 20;86(10):1634-8
7-methyl-10,11-ethylenedioxy-20-camptothecin  0   Camptothecin/*analogs & derivatives Alkaloids. Clin Cancer Res 2002 Mar;8(3):856-62
DE-310 cpd  0   Camptothecin/*analogs & derivatives. Nippon Geka Gakkai Zasshi 2002 Feb;103(2):224-8
7-ethyl-10-hydroxycamptothecin glucuronide  0   *Glucuronides Camptothecin/*analogs & derivatives. Biochem Biophys Res Commun 2001 Nov 9;288(4):827-32
20-O-(Nalpha-(4-(3-O-methylfucopyranosyloxy)phenylaminothiocarbonyl)histidylvalyl)camptothecin  0   *Dipeptides Camptothecin/*analogs & derivatives. J Med Chem 2001 Nov 22;44(24):4186-95
7-tert-butoxyiminomethylcamptothecin  0   Camptothecin/*analogs & derivatives. J Med Chem 2001 Sep 27;44(20):3264-74
ST 1481  0   Camptothecin/*analogs & derivatives. Cancer Res 2001 Aug 15;61(16):6034-7
Karenitecin  0   Camptothecin/*analogs & derivatives. Cancer Chemother Pharmacol 2001 Jul;48(1):83-7
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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