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Cantharidin

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Definition: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.     
Pharmacological Action Enzyme Inhibitors; Irritants 		Other names Cantharides; Cantharidine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CAN 032  0   *Thiazoles Cantharidin/*analogs & derivatives. Int J Mol Med 2006 May;17(5):945-9
demethylcantharidin  0   Cantharidin/*analogs & derivatives. J Chromatogr A 2002 Feb 22;947(2):319-26
cantharidin methylimide  76970-78-0   *Isoindoles Cantharidin/*analogs & derivatives. J Pharm Sci 1989;78(1):66
hexahydro-3a,7a-dimethyl-4,7-epoxy-1H-isoindole-1,3(2H)-dione  76970-77-9   *Isoindoles Cantharidin/*analogs & derivatives. J Pharm Sci 1989;78(1):66
N-hydroxycantharidinimide  76057-97-1 4,7-Epoxy-1H-isoindole-1,3(2H)-dione, hexahydro-2-hydroxy-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)  Cantharidin/*analogs & derivatives. Yao Hsueh Hsueh Pao 1981;16(5):328
disodium cantharidin  1465-77-6   Cantharidin/*analogs & derivatives Phosphoprotein Phosphatases/antagonists & inhibitors. Chung Hua Chung Liu Tsa Chih 1980;2(2):96

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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