encyclopedia of medical concepts
ψ 
ψ 

Cardiac Glycosides

More information in Books or onNLM PubMed
Definition: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.     
Pharmacological Action Anti-Arrhythmia Agents; Cardiotonic Agents; Enzyme Inhibitors
Examples Bufanolides; Cardenolides 		Other names Cardiotonic Steroids; Steroids, Cardiotonic; Glycosides, Cardiac
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
oleandrigenin-beta-D-glucosyl (1-4)-beta-D-digitalose  0   *Cardenolides *Cardiac Glycosides *Methylgalactosides Influenza A Virus, H1N1 Subtype/drug effects. Phytomedicine. 2012 Jan 15;19(2):111-4
3beta-O-(alpha-L-rhamnopyranosyl)-14beta-hydroperoxy-5beta-hydroxy-19-oxo-17beta-card-20(22)-enolide  0   *Cardiac Glycosides. Planta Med. 2010 Oct;76(15):1717-23
toxicarioside G  0   *Cardiac Glycosides. J Asian Nat Prod Res. 2009 Sep;11(9):832-7
toxicarioside F  0   *Cardiac Glycosides. J Asian Nat Prod Res. 2009 Sep;11(9):832-7
toxicarioside H  0   *Cardiac Glycosides. Molecules 2009;14(9):3694-9
2'-epi-2'-O-acetylthevetin B  0   *Cardiac Glycosides. Cell Biol Int. 2009 Sep;33(9):918-25
erysimin G  0   *Cardiac Glycosides. Acta Pharmacol Sin 2001 May;22(5):411-4
Anvirzel  0   *Cardenolides Cardiac Glycosides. Biochem Pharmacol 2001 Aug 15;62(4):469-72
cannogenin thevetoside  1182-87-2   *Cardenolides Cardiac Glycosides.
evomonoside  508-93-0   Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Planta Med 1995 Jun;61(3):294-5
deglucohyrcanoside  14614-16-5   *Cardiac Glycosides Plant Extracts. Ceska Slov Farm 1994 Nov;43(6):298-302
hyrcanoside  15001-93-1   *Cardiac Glycosides Plant Extracts. Ceska Slov Farm 1994 Nov;43(6):298-302
thevetin B  27127-79-3   *Cardenolides Cardiac Glycosides. J Pharm Biomed Anal 1992 Jun;10(6):413-9
acetyltanghinin  4988-26-5   *Cardiac Glycosides. Arch Int Pharmacodyn Ther 1990;307:83
tanghinin  25390-16-3   *Cardiac Glycosides. Arch Int Pharmacodyn Ther 1990;307:83
22,23-dihydrobufalin  123623-38-1 Buf-20-enolide, 3,14-dihydroxy-, (3beta,5beta)  *Bufanolides Cardiac Glycosides. Naunyn Schmiedebergs Arch Pharmacol 1990;342(5):598
17-(3'-thiophenyl)androstane-3,14-diol 3-glucopyranoside  131073-99-9   *Androstanols Cardiac Glycosides. Steroids 1990 Feb;55(2):65-8
ghalakinoside  119459-76-6 Card-20(22)-enolide, 12,14,19-trihydroxy-2,3-((tetrahydro-3,4-dihydroxy-6-(hydroxymethyl)-2H-pyran-3,2-diyl)bis(oxy))-, (3beta(2S,3S,4S,6S),5alpha,12beta)  *Cardiac Glycosides. J Ethnopharmacol 1989;27(1-2):235
bryotoxin B  105608-31-9   *Bufanolides Cardiac Glycosides. Aust Vet J 1989;66(11):374
bryotoxin A  101329-50-4   *Bufanolides Cardiac Glycosides. Aust Vet J 1989;66(11):374
7,8-epoxysinogenin 3-methylglycosides  118004-72-1   *Cardiac Glycosides. Acta Crystallogr C 1988;44(Pt 6):1066
cryptosin  111420-57-6 Card-20(22)-enolide, 3-((2-deoxy-beta-D-arabino-hexopyranosyl)oxy)-7,8-epoxy-11,14-dihydroxy-12-oxo-, (3beta,5beta,7beta,11beta)  *Cardiac Glycosides. Biochem Pharmacol 1989;38(12):2039
bryophyllin A  105608-32-0   *Bufanolides Cardiac Glycosides. Chem Pharm Bull (Tokyo) 1988;36(4):1615
methylepoxyproscillaridin  116387-44-1   Proscillaridin/*analogs & derivatives Cardiac Glycosides. Int J Clin Pharmacol Ther-Toxicol 1988;26(5):243
3-(4-azido-3-iodophenyl)propionamide-4-(4,6-dideoxyglucosyl)digitoxigenin  112761-66-7   *Azides Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Anal Biochem 1988;168(1):39
maquiroside A  110187-24-1 Card-20(22)-enolide, 3-((2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-14,19-dihydroxy-, (3beta,5beta)  Cardiac Glycosides. J Nat Prod 1987;50(2):211
gomphoside  36597-51-0   *Cardenolides Cardiac Glycosides. J Steroid Biochem 1987;28(1):65
Miroton  8060-30-8   *Cardiac Glycosides *Plant Extracts Liliaceae Nerium. Methods Find Exp Clin Pharmacol 1986;8(10):643
uzarigenin-glucoside-canaroside  100857-42-9   Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Planta Med 1985;(6):498
cardiodigin  83452-92-0 Cardiodigin  *Cardiac Glycosides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. FEBS Lett 1985;184(1):150
Linctus Codeine, AFP  0   *Cardiac Glycosides *Codeine Drug Combinations. Med J Aust 1984;140(1):54
24-azido-3-((2,6-dideoxy-beta-hexapyranosyl)oxy)-14-hydroxy-21-norchol-20(22)-en-23-one  87830-63-5   *Azides *Cardiac Glycosides. Biochemistry 1983;22(26):6303
acrihellin  67696-82-6 Bufa-20,22-dienolide, 5,14-dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-oxo-, (3beta,5beta)  *Bufanolides Cardiac Glycosides. Arzneimittelforsch 1983;33(8):1106
cotyledoside  57364-74-6   *Bufanolides Cardiac Glycosides. Onderstepoort J Vet Res 1982;49(4):247
digitoxigenin arabinoside  78614-49-0 Card-20(22)-enolide, 3-(alpha-L-arabinofuranosyloxy)-14-hydroxy-, (3beta,5beta)  Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Pharmazie 1982;37(12):827
digitoxigenin-galactose  33275-60-4   Digitoxigenin/*analogs & derivatives Cardiac Glycosides. J Pharmacol Exp Ther 1982;223(3):761
pennogenin tetraglycoside  55916-45-5   *Spirostans Cardiac Glycosides. Yakugaku Zasshi 1982;102(5):495
cardiac glycoside receptors  0   *Sodium-Potassium-Exchanging ATPase Cardiac Glycosides Digoxin Ouabain. Biochem Pharmacol 1980;29(24):3219
rohdealine  0   *Cardiac Glycosides. Chung Hua Hsin Hsueh Kuan Ping Tsa Chih 1979;7(4):249
scillaren  11003-70-6   *Cardiac Glycosides.
cannogenol-3-O-alpha-L-rhamnoside  6869-58-5 Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-14,19-dihydroxy-, (3beta,5beta)  Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Planta Med 1980;40(1):1
cannogenol-3-O-beta-D-allomethyloside  546-02-1 card-20(22)-enolide, 3-((6-deoxy-D-allopyranosyl)oxy)-14,19-dihydroxy-, (3 beta,5 alpha)  Digitoxigenin/*analogs & derivatives Cardiac Glycosides. Planta Med 1980;40(1):1
scilliroside  507-60-8 6 beta-(acetyloxy)-3-beta-(beta-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolide  *Bufanolides Cardiac Glycosides. Lloydia 42(5):522;1979
scillaren A  124-99-2 3 beta-((6-deoxy-4-O-beta-D-glucopyranosyl- alpha-L-mannopyranosyl)oxy)-14-hydroxy-bufa-4, 20,22-trienolide  *Bufanolides Cardiac Glycosides. Lloydia 42(5):522;1979
oleandrin  465-16-7 (3 beta,16 beta)-16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxy card-20(22)-enolide  *Cardenolides Cardiac Glycosides. Arch Int Pharmacodyn Ther 239(2):283;1979
helveticosol 3',4'-dinitrate  51943-33-0 (3 beta,5 beta)-3-((2,6-dideoxy-3,4-di-O- nitro-beta-D-ribo-hexopyranosyl)oxy)-5,14,19- trihydroxycard-20(22)-enolide  *Strophanthins Cardiac Glycosides Digitalis Glycosides. Arch Int Pharmacodyn Ther 239(2):270;1979
SC 4453  59712-21-9 beta-D-ribo-Hexopyranoside, (3beta,5beta,12beta,14beta,17beta)-12,14-dihydroxy-17-(4-pyridazinyl)androstan-3-yl O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy  Digoxin/*analogs & derivatives Cardiac Glycosides. Arch Int Pharmacodyn Ther 239(1):171;1979
asclepin  36573-63-4 (2 alpha,3 beta,5 alpha)-3-((3-O-acetyl-4,6-dideoxy-D-erythro-hexopyranos-2-ulos-1-yl)oxy) card-20(22)-enolide  *Cardenolides Cardiac Glycosides. Arzneim Forsch 28(8):1368;1979
cuspidoside  11050-23-0   *Cardiac Glycosides. Ter Arkh 50(1):69;1978
thevetoside  0   *Cardiac Glycosides. Chin Med J 3(5):315;1977
olitoriside  13289-20-8   *Cardenolides Cardiac Glycosides. Farm Zh (3):41;1979; Farm Zh (5):89;1978; Pharmazie 31(8):565;1976
glucoolitoriside  39028-64-3 Card- 20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-2,6-dideoxy-beta-D-xylo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)  *Cardenolides Cardiac Glycosides Glycosides. Pharmazie 31(8):565;1976
erysimoside  7082-34-0   *Cardenolides Cardiac Glycosides Glycosides. Pharmazie 31(8):565;1976
corchoroside A  508-76-9   *Cardenolides Cardiac Glycosides. Acta Pharm Sinica 1979;14(3):267; Farmatsiia 27(3):28;1978; Pharmazie 31(8):565;1976
adonitoxin  17651-61-5   *Cardenolides Cardiac Glycosides. Pharmazie 31(8):565;1976
bovoside  11028-14-1   *Cardiac Glycosides. Vrach Delo 9:39;1976
ASI-222  59006-00-7 (3 beta,5 beta)-3-((4-amino-4,6-dideoxy-beta-D-galactopyranosyl)oxy)-14-hydroxycard-20(22)-enolide  Digitoxigenin/*analogs & derivatives Cardiac Glycosides Digitalis Glycosides. Arch Int Pharmacodyn Ther 227:220;1977; Circ Res 43(6):847;1978; J Pharmacol Exp Ther 197(1):19;1976
Venocuran  78920-42-0 Venocuran  *Cardiac Glycosides *Plant Extracts *Pyrazoles Drug Combinations. Lancet 2(7926):144;1975; Nouv Presse Med 6(32):2873;1977
scillicyanoside  11005-49-5   *Bufanolides Cardiac Glycosides. Helv Chim Acta 56(7):2117;1973
hellebrin  13289-18-4   *Bufanolides Cardiac Glycosides Ranunculaceae. Acta Pharm Hung 47(4):162;1977; Planta Medica 26(3):250;1974
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy