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Carmustine

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Definition: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)     
Pharmacological Action Antineoplastic Agents, Alkylating 		Other names BCNU; FIVB; Nitrumon; N,N'-Bis(2-Chloroethyl)-N-Nitrosourea; BiCNU; 1,3-Bis(2-Chloroethyl)-1-NitrosoureaDrugs* : BICNU
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-chloroethyl-N-nitrosourea hydrochloride  0   Carmustine/*analogs & derivatives. Acta Crystallogr C. 2012 Mar;68(Pt 3):o144-8
MBVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Methotrexate Methylprednisolone Teniposide. Neurology 2004 Feb 24;62(4):544-7
ICBV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide Idarubicin. Int J Hematol 2004 Jan;79(1):85-91
carmustine with prolifeprosan 20  0   *Carmustine. Curr Neurol Neurosci Rep 2001 May;1(3):210-6
FBM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Melphalan Vidarabine/analogs & derivatives. Bone Marrow Transplant. 2000 Aug;26(3):243-50
STAMP-I protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Cyclophosphamide. Bone Marrow Transplant 2000 May;25(10):1047-52
DBPT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Jun;82(11):1759-63
BEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Etoposide Melphalan. Bone Marrow Transplant 2000 Feb;25(3):309-13
DBCT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Mar;82(6):1158-62
BMPD protocol  0   Carmustine Dexamethasone *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine. Leukemia Lymphoma 1998 Aug;30(5-6):609-17
BOMES protocol  0   Carmustine Methotrexate *Antineoplastic Combined Chemotherapy Protocols Etoposide Methylprednisolone Hemisuccinate Vincristine. Oncology 1995 Nov-Dec;52(6):501-4
BCHE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide Hydroxyurea. J Clin Oncol 1995 May;13(5):1089-95
PECC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisone Vindesine. J Clin Oncol 1994 Dec;12(12):2706-13
Dexa-BEAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Dexamethasone Etoposide Melphalan. J Clin Oncol 1994 Mar;12(3):580-6
FMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Floxuridine Mitomycins. J Clin Oncol 1993 Feb;11(2):330-5
VBAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Dexamethasone Doxorubicin Vincristine. Eur J Cancer 1992;29A(1):57-60
VDBCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Doxorubicin Prednisone Vincristine. Acta Haematol 1991;22(1):6-20
FIB-P protocol  0   *Antineoplastic Combined Chemotherapy Protocols Aminoimidazole Carboxamide Carmustine Fluorouracil Prednisolone Salvage Therapy. Tumori 1992 Feb 29;78(1):26-31
BBVDD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Carmustine Cisplatin Dexamethasone Teniposide. Am J Clin Omcol 1991;14(6):519
BVAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Methotrexate Vincristine. Clin Oncol (R Coll Radiol) 1991;3(4):193
DBPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Oncology (Williston Park) 1991;5(5):95
MBCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Fluorouracil Mitomycin. Korean J Intern Med 1987;2(1):48
BOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Procarbazine Vincristine. J Chemother 1990;2(1):67
BCPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisolone Procarbazine. Gan To Kagaku Ryoho 1989;16(6):2269
FIVB+P protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Dacarbazine Fluorouracil Prednisone Vincristine. Dtsch Med Wochenschr 1989;114(24):935
BMVC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Etoposide Mitoxantrone. Haematologica (Pavia) 1989;74(1):67
BEAM regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Etoposide Melphalan. Cancer Chemother Pharmacol 1988;22(3):256
ABCM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Doxorubicin Melphalan. Hematol Oncol 1988;6(2):145
VBAMDex protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Dexamethasone Doxorubicin Melphalan Vincristine. Eur J Haematol 1988;40(3):245
BAVC protocol  0   Amsacrine *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Etoposide. Ann NY Acad Sci 1987;511:483
BAEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Etoposide. Scand J Haematol 1986;37(4):347
BFHM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Fluorouracil Hydroxyurea 6-Mercaptopurine. Cancer Treat Rep 1986;70(11):1271
BAFMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Doxorubicin Fluorouracil Mitomycins. Cancer Treat Rep 1986;70(4):481
UCH II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Methotrexate. Cancer Chemother Pharmacol 1986;16(2):170
UCH I protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine. Cancer Chemother Pharmacol 1986;16(2):170
BEAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Melphalan Podophyllotoxin. Cancer Chemother Pharmacol 1986;16(2):170
DEMOB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Dexamethasone Methotrexate Vincristine. Cancer 1986;57(1):6
VP-BBML protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Carmustine Leucovorin Etoposide Methotrexate. Cancer Treat Rep 1985;69(7-8):783
N-chloroethylnitrosourea asparaginamide  81965-31-3   Carmustine/*analogs & derivatives. Cancer Chemother Pharmacol 1985;14(2):156
2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide  92891-93-5   Carmustine/*analogs & derivatives.
Pharma Action Antineoplastic Agents 		Cancer Chemother Pharmacol 1985;14(2):156
BMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Melphalan Prednisone. Cancer Treat Rep 1984;68(12):1439
EBAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Doxorubicin Prednisone Vindesine. Cancer Treat Rep 1984;68(7-8):963
FAB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Doxorubicin Fluorouracil. Cancer Chemother Pharmacol 1984;12(3):194
BACT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Thioguanine. Eur J Cancer Clin Oncol 1983;19(10):1371
BVCPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisone Procarbazine Vinblastine. Cancer 1983;52(12):2209
CBV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide. Eur J Cancer Clin Oncol 1983;19(8):1091
ABC protocol  0   Carmustine *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin. Med Pediatr Oncol 1983;11(3):151
BCVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisone Vincristine. Cancer 1983;51(9):1581
L-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Daunorubicin Hydroxyurea Methotrexate Thioguanine Vincristine. Cancer 1982;50(8):1462
BCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisone. Cancer Treat Rep 1982;66(6):1273
VBAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Doxorubicin Prednisone Vincristine. Cancer Treat Rep 1982;66(6):1267
M-2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Melphalan Prednisone Vincristine. Blood 1982;59(5):934
BCOMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Methotrexate Mitoguazone Vincristine. Cancer Chemother Pharmacol 1982;8(1):73
1,3-bis(3-chloro-2-butyl)-1-nitrosourea  63548-66-3 Urea, N,N'-bis(2-chloro-1-methylpropyl)-N-nitroso  Carmustine/*analogs & derivatives. J Org Chem 42(22):3538;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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