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Catechol O-Methyltransferase

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Definition: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine. EC 2.1.1.6.      Other names O-Methyltransferase, Catechol; Methyltransferase, Catechol; Catechol O Methyltransferase; Catechol-O-Methyltransferase; Catechol Methyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide  0   *Oxadiazoles Catechol O-Methyltransferase/antagonists & inhibitors. J Med Chem 2010 Apr 22;53(8):3396-411
quinalizarin  0   *Anthraquinones Catechol O-Methyltransferase/antagonists & inhibitors. Biochem J 2009 Aug 1;421(3):387-95
3,4-dihydroxy-2-nitrobenzophenone  0   *Benzophenones *Nitrophenols Catechol O-Methyltransferase/antagonists & inhibitors. Mol Pharmacol 2006 Jul;70(1):143-53
3,4-dihydroxy-5-nitrobenzophenone  0   *Benzophenones *Nitrophenols Catechol O-Methyltransferase/antagonists & inhibitors. Mol Pharmacol 2006 Jul;70(1):143-53
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone  0   *Acetophenones Catechol O-Methyltransferase/antagonists & inhibitors Parkinson Disease/drug therapy. Eur J Pharmacol 2001 May 18;420(1):27-32
3-(3-hydroxy-4-methoxy-5-nitrobenzylidene)-2,4-pentanedione  118724-88-2   *Benzylidene Compounds *Nitro Compounds Catechol O-Methyltransferase/antagonists & inhibitors. Biochem Pharmacol 1993 May 25;45(10):1973-81
entacapone  116314-67-1 (E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide  *Catechols *Nitriles Catechol O-Methyltransferase/antagonists & inhibitors.
Pharma Action Antiparkinson Agents ; Enzyme Inhibitors 		Clin Neuropharmacol 1991;14(4):330COMTAN; STALEVO 100
N-(3,4-dihydroxyphenyl)maleimide  71573-09-6   *Catechols *Maleimides Catechol O-Methyltransferase/antagonists & inhibitors. J Enzym Inhib 1990;4(1):43
tolcapone  134308-13-7   *Benzophenones *Nitrophenols Catechol O-Methyltransferase/antagonists & inhibitors.
Pharma Action Antiparkinson Agents ; Enzyme Inhibitors 		Adv Neurol 1990;53:497TASMAR
1-carboxysalsoline  88598-26-9   *Salsoline Alkaloids Catechol O-Methyltransferase/antagonists & inhibitors. Z Naturforsch (C) 1989;44(1-2):173
salsolidine  5784-74-7   *Salsoline Alkaloids Catechol O-Methyltransferase/antagonists & inhibitors. Z Naturforsch (C) 1989;44(1-2):173
OR486  7659-29-2   *Catechols Catechol O-Methyltransferase/antagonists & inhibitors. Eur J Pharmacol 1988;153(2-3):263
nitecapone  116313-94-1   *Catechols *Pentanones Catechol O-Methyltransferase/antagonists & inhibitors.
Pharma Action Anti-Ulcer Agents ; Antioxidants ; Enzyme Inhibitors 		J Pharmacol Exp Ther 1988;247(1):289
5-hydroxy-3-mercapto-4-methoxybenzoic acid  80547-87-1 Benzoic acid, 3-hydroxy-5-mercapto-4-methoxy  *Hydroxybenzoic Acids *Sulfhydryl Compounds Catechol O-Methyltransferase/antagonists & inhibitors. J Med Chem 1982;25(3):321
5,6-dihydroxyindole  3131-52-0   *Indoles Catechol O-Methyltransferase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Med Chem 1982;25(3):263
methylspinazarin  41768-12-1 1,4-Naphthalenedione, 2,3,5,8-tetrahydroxy-6-methyl  *Naphthoquinones Catechol O-Methyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 26(2):112;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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