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Chelating Agents

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Definition: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.  coordinate with specific chelating agent + metal being chelated   
See Also Antidotes; Iron Chelating Agents
Examples Iron Chelating Agents 		Other names Complexons; Metal Antagonists; Antagonists, Metal; Agents, Chelating; Chelators
Substances having this pharmacologic action: chelex; sodium thiosulfate; (ethylenedinitrilo)-tetramethylenephosphonic acid; tetrathiomolybdate; pyridoxal isonicotinoyl hydrazone; 1,10-phenanthroline; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; EDDA; triethylenetetraminehexaacetic acid; N-(hydroxyethyl)ethylenediaminetriacetic acid; cobalt-ethylenediamine tetraacetic acid chelate; bathocuproine sulfonate; Quin2-acetoxymethyl ester; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; dihydroxyethyldithiocarbamate; 5,5'-difluoro-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; iminodiacetic acid; dipicolinic acid; CDTA; Chitosan; neocuproine; Phytochelatins; alanosine; Fura-2; Technetium Tc 99m Pentetate; Ditiocarb; Razoxane; Thenoyltrifluoroacetone; Nitrilotriacetic Acid; Unithiol; 2,2'-Dipyridyl; Trientine; Citric Acid; Penicillamine; Dimercaprol; Succimer; Dithizone; Cuprizone; Pentetic Acid; Edetic Acid; Egtazic Acid; Humic Substances; Caseins; disalicylaldehyde ethylenediamine; benphothiamine; bathophenanthroline disulfonic acid; calcium acetate; sevelamer; zinquin; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; Indo-1 pentaacetoxymethyl ester; diazo-2; theaflavin; 1-(2-nitro-4,5-dimethoxyphenyl)-N,N,N',N'-tetrakis((oxycarbonyl)methyl)-1,2-ethanediamine; 5,5'-dimethyl-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate; acteoside; N-benzylglucamine dithiocarbamate; indo-1; gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; nitr 5; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
triazacyclononane-phosphinic acid  0   *Aza Compounds *Phosphinic Acids Chelating Agents. Chemistry. 2011 Dec 23;17(52):14718-22
cysteinyl-phenyl-triaminohexaacetate  0   *Acetic Acids Cysteine/*analogs & derivatives Chelating Agents. J Biomol NMR. 2011 Nov;51(3):329-37.
ethylenediaminetetraacetic acid bis-(ethyl phenylalaninate)  0   Edetic Acid/*analogs & derivatives Chelating Agents. Bioorg Med Chem Lett 2001 Oct 8;11(19):2573-5
Phen Green SK  0   Organic Chemicals Chelating Agents Fluorescent Dyes. Toxicol Appl Pharmacol 2001 Jul 1;174(1):27-34
(1,4,7-trimethyl-1,4,7-triazacyclononane)iron(III)  0   *Ferric Compounds Chelating Agents. Nucleic Acids Res 1998 May1;26(9):2086-91
1,4,7-triazacyclononane  4730-54-5 1H-1,4,7-Triazonine, octahydro  *Heterocyclic Compounds Chelating Agents. Int J Rad Appl Instrum (B) 1992 Apr;19(3):269-74
Trialon B  128523-75-1   Organic Chemicals Chelating Agents. Zh Mikrobiol Epidemiol Immunobiol 1989;8:5
Benz2  0   Organic Chemicals Calcium Chelating Agents. Biochim Biophys Acta 1984;773(1):143
Chelex 100  11139-85-8   *Resins, Synthetic Cation Exchange Resins Chelating Agents. Biochem Biophys Res Commun 1980;93(2):558

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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