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Chlorambucil

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Definition: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)     
Pharmacological Action Antineoplastic Agents, Alkylating
Examples Prednimustine 		Other names NSC3088; NSC 3088; CB1348; Wellcome Brand of Chlorambucil; NSC-3088; N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid; CB 1348; Lympholysin; Leukeran; GlaxoSmithKline Brand of Chlorambucil; Glaxo Wellcome Brand of Chlorambucil; Chlorbutin; Chloraminophene; CB-1348; Amboclorin; 4-(Bis(2-chloroethyl)amino)benzenebutanoic AcidDrugs* : LEUKERAN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chlorambucil-N-(2-(4-(4-bis(2-chloroethyl)aminophenyl)butyryl)aminoethyl)-5-(4-amidinophenyl)-2-furancarboxamide hydrochloride  0   Chlorambucil/*analogs & derivatives. Eur J Pharmacol. 2004 May 25;492(2-3):95-101
ChlVPP-EVA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisolone Procarbazine Vinblastine Vincristine. J Clin Oncol 2002 Jul 1;20(13):2988-94
LBCMVD-56 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Dexamethasone Lomustine Methotrexate Vincristine. Ann Oncol. 2000 Jul;11(7):857-60
MCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Mitoxantrone Prednisolone. Clin Oncol (R Coll Radiol)1999;11(3):184-6
chlorambucil half mustard  0   *Chlorambucil Mutagens. Mutat Res 1998 Jun 5;401(1-2):153-64
chlorambucil-taurocholate  0   Chlorambucil/*analogs & derivatives Taurocholic Acid/*analogs & derivatives Drug Carriers. Gastroenterology 1997 Oct;113(4):1295-305
COA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Cytarabine Vincristine. Leuk Lymphoma 1995 Mar;17(1-2):147-53
PEEC-M protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Etoposide Methotrexate Methylprednisolone Vindesine. Br J Cancer 1994 Sep;70(3):501-5
chlorambucil N-oxide  35915-68-5   *Cyclic N-Oxides Chlorambucil/*analogs & derivatives. J Chromatogr 1994 Feb 11;652(2):195-202
MVLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Mitoxantrone Prednisone Teniposide. Neth J Med 1993 Apr;42(3-4):122-7
chlorambucil-spermidine conjugate  143984-22-9   Chlorambucil/*analogs & derivatives Spermidine/*analogs & derivatives. Cancer Res 1992 Aug 1;52(15):4190-5
LOPP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisolone Procarbazine Vincristine. Br J Cancer 1991;63(4):579
CHLOROPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Procarbazine. Br J Radiol 1991;64(757):55
CMPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Mitoxantrone Prednisolone Procarbazine. Acta Oncol 1990;29(6):733
chlorambucil-docosahexaenoic acid conjugate  130388-13-5   *Docosahexaenoic Acids Chlorambucil/*analogs & derivatives. Biochem Pharmacol 1990;40(6):1193
chlorambucil-oleic acid conjugate  130676-88-9   *Oleic Acids Chlorambucil/*analogs & derivatives. Biochem Pharmacol 1990;40(6):1193
chlorambucil-arachidonic acid conjugate  130676-89-0   *Arachidonic Acids Chlorambucil/*analogs & derivatives. Biochem Pharmacol 1990;40(6):1193
chlorambucil-tertiary butyl ester  119054-09-0   Chlorambucil/*analogs & derivatives. Cancer Chemother Pharmacol 1990;25(5):320
LMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Fluorouracil Methotrexate. Recent Results Cancer Res 1989;115:175
PEEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Etoposide Methylprednisolone Vindesine. Scott Med J 1988;33(6):360
OPEC protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Etoposide Prednisolone Vincristine. Hematol Oncol 1987;5(2):79
17-hydroxy-4-aza-A-nor-5-androsten-3-one (4-N,N-bis(2-chloroethylamino)phenyl)butyrate  107534-94-1   *Azasteroids Chlorambucil/*analogs & derivatives. Oncology 1986;43(6):390
3-hydroxy-13,17-seco-5-androsten-17-oic-13,17-lactam (4-(bis(2-chloroethyl)amino)phenyl)butyrate  107480-21-7   *Azasteroids Chlorambucil/*analogs & derivatives. Oncology 1986;43(6):344
3-hydroxy-13,17-secoandrostan-17-oic-13,17-lactam (4-(bis(2-chloroethyl)amino)phenyl)butyrate  68426-41-5   *Azasteroids Chlorambucil/*analogs & derivatives. Oncology 1986;43(6):344
17-hydroxy-3-aza-A-homo-4-androsten-4-one (4-(bis(2-chloroethyl)amino)phenyl)butyrate  99876-94-5   *Azasteroids Chlorambucil/*analogs & derivatives. Oncology 1986;43(6):344
CHIVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisone Procarbazine Vinblastine. Ir J Med Sci 1986;155(9):300
3,3-difluorochlorambucil  103638-41-1   Chlorambucil/*analogs & derivatives. Cancer Chemother Pharmacol l986;17(1):21
VCCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Cyclophosphamide Prednisone Vincristine. Tumori 1983;69(6):589
MDC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Dactinomycin Methotrexate. Ginekol Pol 1983;54(10):641
LMFP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Fluorouracil Methotrexate Prednisone. Dtsch Med Wochenschr 1983;108(48):1827
1,3-dipalmitoyl-2-(4-(bis(2-chloroethyl)amino)benzenebutanoyl)glycerol  85763-07-1   Chlorambucil/*analogs & derivatives. J Med Chem 1983;26(8):1200
bestrabucil  75219-46-4 Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate 17-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate)  Chlorambucil/*analogs & derivatives Estradiol/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Immunosuppressive Agents 		Rinsho Ketsueki 1982;23(9):1415
ChlVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisolone Procarbazine Vinblastine. Br J Cancer 1982;45(6):851
APC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Aminoacridines Chlorambucil Prednisone. Cancer Treat Rep 1982;66(5):1235
VAB-IV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Vinblastine. Can J Surg 1982;25(3):265
VAB-III protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Cisplatin Cyclophosphamide Dactinomycin Vinblastine. Cancer Treat Rep 1982;66(6):1405
chlorambucyl-proline  81050-71-7 L-Proline, 1-(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutyl)  Chlorambucil/*analogs & derivatives Proline/*analogs & derivatives. J Biol Chem 1982;257(2):811
3,4-dehydrochlorambucil  73027-06-2 3-butenoic acid, 4-(4-(bis(2-chloroethyl)amino)phenyl)-, (E)  Chlorambucil/*analogs & derivatives. Chem Biol Interact 1979;28(2-3):211
aminochlorambucil  3688-35-5 Benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)  Chlorambucil/*analogs & derivatives. C R Soc Biol 286(11):905;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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