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Chloramphenicol

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Definition: An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)  an antibiotic   
Pharmacological Action Anti-Bacterial Agents; Protein Synthesis Inhibitors
Examples Thiamphenicol 		Other names Levomycetin; Kloramfenikol; Cloranfenicol; Syntomycin; Ophthochlor; Detreomycin; Chloromycetin; Chlorocid; ChlornitromycinDrugs* : CHLOROMYXIN; ELASE-CHLOROMYCETIN; CHLORAMPHENICOL; OPHTHOCHLOR; CHLOROMYCETIN HYDROCORTISONE; OPTOMYCIN; CHLOROPTIC; OPHTHOCORT; CHLOROPTIC-P S.O.P.; AMPHICOL; MYCHEL; CHLOROPTIC S.O.P.; CHLOROFAIR; CHLOROMYCETIN; ECONOCHLOR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chloramphenicol, dexamethasone, neomycin drug combination  0   *Chloramphenicol *Dexamethasone *Neomycin Drug Combinations. SADJ 2006 May;61(4):154-9
Cervugid  0   *Chloramphenicol *Metronidazole *Nystatin Drug Combinations. Rev Med Chir Soc Med Nat Iasi 2004 Jul-Sep;108(3):628-34
chloramphenicol, colistimethate sodium, rolitetracycline drug combination  0   *Chloramphenicol *Colistin *Rolitetracycline Drug Combinations. Vestn Oftalmol 1998 Mar-Apr;114(2):32-4
chloramphenicol oxamylethanolamine  0   Chloramphenicol/*analogs & derivatives. Chem Res Toxicol 1995 Jul-Aug;8(5):642-8
2-chloro-2-fluoro-N-(2-(4-nitrophenyl)ethyl)acetamide  135248-51-0   Chloramphenicol/*analogs & derivatives. Toxicol Appl Pharmacol 1994 May;126(1):26-32
Eubetal  0   *Betamethasone *Chloramphenicol *Colistin *Tetracycline Drug Combinations. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publi 1991;68:83-7
lincophenicol  148077-13-8 2-Pyrrolidinecarboxamide, N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-1-methyl-4-propyl-, (2S-(2alpha(1S*,2S*),4beta))  Chloramphenicol/*analogs & derivatives. J Med Chem 1993 Apr 30;36(9):1239-44
fast cat  147211-28-7   *Boron Compounds Chloramphenicol/*analogs & derivatives. Methods Enzymol 1992;216:369-76
1,3-diacetylchloramphenicol  10318-17-9   Chloramphenicol/*analogs & derivatives. Biochemistry 1992 Sep 8;31(35):8191-5
1-deoxychloramphenicol  133191-51-2   Chloramphenicol/*analogs & derivatives. Nucleic Acids Res1991;19(23):6648
aminodehydrochloramphenicol  129085-22-9   Chloramphenicol/*analogs & derivatives. J Chromatogr Sci 1990;28(5):236
dehydrochloramphenicol  26367-75-9   Chloramphenicol/*analogs & derivatives. Pharmacology 1988;36(4):272
1-(4-nitrophenyl)-2-amino-1,3-propandedione  90417-68-8   Chloramphenicol/*analogs & derivatives. Pharmacology 1988;36(4):272
levomecol  118573-58-3   *Chloramphenicol Drug Combinations Uracil/*analogs & derivatives. Stomatologiia (Mosk) 1987;66(5):42
fokalmin  126663-41-0   *Chloramphenicol *Neomycin *Phenylmercuric Acetate *Prednisolone Drug Combinations. Vojnosanit Pregl 1986;43(2):137
1-(4-nitrophenyl)-2-dichloroacetamidoethane  102904-25-6   Chloramphenicol/*analogs & derivatives. Mol Pharmacol 1986;29(4):391
3-(bromoacetyl)chloramphenicol  95610-68-7   Chloramphenicol/*analogs & derivatives. Biochemistry 1985;24(20):5307
diflucortolone - josamycin drug combination  0   *Chloramphenicol *Josamycin Drug Combinations. Minerva Stomatol 1984;33(5):875
2-(phenylalanylglycyl)amino-3-(4-nitrophenyl)-1,3-propanediol  93359-23-0 Glycinamide, L-phenylalanyl-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))  Chloramphenicol/*analogs & derivatives. Biochem Biophys Res Commun 1984;122(2):748
perchlorylchloramphenicol  70487-35-3 Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-perchlorylphenyl)ethyl)-, (R*,R*)-(+-)  Chloramphenicol/*analogs & derivatives. Pharmazie 1983;38(9):587
sparsophenicol  82647-22-1 2-Propenamide, N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,R*-(E)))  Chloramphenicol/*analogs & derivatives. J Med Chem 1982;25(10):1123
3-fluorochloramphenicol  73212-55-2   Chloramphenicol/*analogs & derivatives. Antimicrob Agents Chemother 1982;19(2):294
azidamfenicol, clotrimazole drug combination  0   *Clotrimazole Chloramphenicol/*analogs & derivatives Drug Combinations. Med Welt 1982;33(14):525
chloramphenicol, dexamethasone isonicotinate, oxytetracycline drug combination  81391-23-3   *Chloramphenicol *Dexamethasone Isonicotinate *Oxytetracycline Drug Combinations. Tijdschr Diergeneeskd 1981;106(22):1166
chloramphenicol stearate  16255-48-4   Chloramphenicol/*analogs & derivatives. Farmaco (Prat) 1981;36(6):294
chloramphenicol palmitate  530-43-8   Chloramphenicol/*analogs & derivatives. J Assoc Off Anal Chem 1981;64(3):557CHLOROMYCETIN PALMITATE
1-(2-benzofuranyl)-2-(dichloroacetamido)propane-1,3-diol  74599-88-5 Acetamide, N-(2-(2-benzofuranyl)-2-hydroxy-1-(hydroxymethyl)ethyl)-2,2-dichloro-, (R*,S*)-(+-)  Chloramphenicol/*analogs & derivatives. Arch Pharm (Weinheim) 1981;314(2):162
chloramphenicol aldehyde  73981-53-0   Chloramphenicol/*analogs & derivatives. Drug Metab Dispos 1980;8(6):371
chloramphenicol glucuronide  39751-33-2   Chloramphenicol/*analogs & derivatives. Cesk Gastroenterol Vyz 1980;34(7):451
chloramphenicol oxamic acid  76567-25-4 Acetic acid, ((2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)amino)oxo-, methyl ester, (R-(R*,R*))  Chloramphenicol/*analogs & derivatives. FEBS Lett 1980;119(1):38
chloramphenicol 3-acetate  10318-16-8   Chloramphenicol/*analogs & derivatives. Biochem Biophys Acta 1980;614(2):339
chloramphenicol 1-acetate  23214-93-9   Chloramphenicol/*analogs & derivatives. Biochim Biophys Acta 1980;614(2):339
nitrosochloramphenicol  67058-47-3   Chloramphenicol/*analogs & derivatives. J Lab Clin Med 1980;96(1):36
chloramphenicol succinate  3544-94-3   Chloramphenicol/*analogs & derivatives.
Pharma Action Anti-Bacterial Agents 		Clin Pharmacol Ther 1980;28(1):69CHLORAMPHENICOL; MYCHEL-S; CHLORAMPHENICOL SODIUM SUCCINATE
1-(4'-nitrophenyl)-2-aminopropane-1,3-diol  119-62-0 2-amino-1-(4-nitrophenyl)-1,3-propanediol  Chloramphenicol/*analogs & derivatives. J Pharm Sci 66(9):1239;1977; J Pharm Sci 67(4):480;1978; J Pharm Sci 68(12):1565;1979
legrazol  78065-44-8 Gramicidin, mixt. with 2-butoxy-N-(2-(diethylamino)ethyl)-4-quinolinecarboxamide and (R-(R*,R*))-2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)acetamide  *Balsams *Chloramphenicol *Dibucaine *Gramicidin Drug Combinations. Vrach Delo (3):92;1979
azidoamphenicol, clotrimazole, dexamethasone drug combination  0   *Clotrimazole *Dexamethasone Chloramphenicol/*analogs & derivatives Drug Combinations. Med Welt 29:1013;1978
fastins  0   *Benzocaine *Chloramphenicol *Nitrofurazone Drug Combinations. Vestn Dermatol Venerol 10:74;1976
4-denitro-4-azidochloramphenicol  0 4-desnitro-4-azidochloramphenicol  *Azides Chloramphenicol/*analogs & derivatives. Hoppe-Seyler Z Physiol Chem 356:1185;1975
allantoin, chloramphenicol, hydrocortisone, nicoboxil, sulfur drug combination  76270-08-1 Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-, mixt. with 2-butoxyethyl 3-pyridinecarboxylate, (R-(R*,R*))-2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)acetamide, (2,5-dioxo-4-imidazolidinyl)urea and sulfur  *Allantoin *Chloramphenicol *Hydrocortisone Drug Combinations. Tropical Doct 5(2):93;1975
dextramycine  134-90-7 Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (S-(R*,R*))  *Chloramphenicol Stereoisomerism. Biull Eksp Biol Med 1979;88(11):590; Z Krebsforsch 82(1):13;1974
monoiodoamphenicol  40027-73-4   Chloramphenicol/*analogs & derivatives. Proc Natl Acad Sci 70(8):2229;1973
iruxol  77648-56-7 Collagenase, mixt. with (R-(R*,R*))-2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)acetamide  *Chloramphenicol *Microbial Collagenase Drug Combinations. Khirurgiia 4:113;1978; ZFA (Stuttgart) 49(17):856;1973
azidoamphenicol  13838-08-9 threo-2-azido-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide  Chloramphenicol/*analogs & derivatives. Arzneim Forsch 28(2):232;1978; Contact Dermatol 1(4):271;1975; Med Welt 29:1013;1978
bromamphenicol  40027-72-3 threo-N-(beta hydroxy-alpha hydroxymethyl-p-nitrophenethyl)dibromoacetamide  Chloramphenicol/*analogs & derivatives. Proc Nat Acad Sci 70(5):1423;1973
tevenel  4302-95-8   Chloramphenicol/*analogs & derivatives. Can J Biochem 50(2):200;1972
Predni-opthiole  0   *Chloramphenicol *Prednisone Drug Combinations Ophthalmic Solutions.

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