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Proguanil

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Definition: A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.     
Pharmacological Action Antimalarials; Antimetabolites 		Other names Chloroguanide; Chlorguanid; Hydrochloride, Proguanil; Hydrochloride, Chloroguanide; Zeneca Brand of Chloroguanide Hydrochloride; Proguanil Hydrochloride; Paludrine; Chloroguanide Hydrochloride; Chloriguane; Paludrin; Bigumal; AstraZeneca Brand of Chloroguanide Hydrochloride; Astra Brand of Chloroguanide Hydrochloride
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
atovaquone-proguanil  0   *Proguanil *Atovaquone Drug Therapy, Combination. Clin Infect Dis 2007 Dec 15;45(12):1588-90
chloroguanil, dapsone drug combination  0   *Dapsone Proguanil/*analogs & derivatives Drug Combinations. JAMA. 2007 May 23;297(20):2201-9
malarone  0   *Proguanil *Atovaquone Drug Combinations.
Pharma Action Antimalarials 		Lancet 1997 Nov 29;350(9091):1624-5ATOVAQUONE AND PROGUANIL HYDROCHLORIDE; MALARONE PEDIATRIC; MALARONE
PS 15  150374-62-2   Proguanil/*analogs & derivatives. Am J Trop Med Hyg 1993 Jul;49(1):121-6
cycloguanil  516-21-2   *Proguanil *Triazines.
Pharma Action Antimalarials ; Folic Acid Antagonists 		Biochem J 1980;187(2):533
Preparation ABP  78393-40-5 Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, mixt. with N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride and N,N-diethyl-N'-(6-methoxy-8-quinolinyl)-1,3-propanediamine  *Aminoquinolines *Proguanil *Quinacrine Drug Combinations. Veterinariia 3:64;1975
chlorproguanil  537-21-3 1-(3,4-dichlorophenyl)-5-isopropylbiguanide  Proguanil/*analogs & derivatives.
Pharma Action Antimalarials

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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