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Chloroquine

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Definition: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.     
Pharmacological Action Amebicides; Antimalarials; Antirheumatic Agents
Examples Hydroxychloroquine 		Other names Sulphate, Chloroquine; Sulfate, Chloroquine; Nivaquine; Khingamin; Chloroquine Sulphate; Chloroquine Sulfate; Chlorochin; Chingamin; Arequin; Arechine; AralenDrugs* : ARALEN HYDROCHLORIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-chloro-N-(3-(4-(dipyridin-2-ylmethylamino)piperidin-1-yl)propyl)quinolin-4-amine  0   *Pyridines Chloroquine/*analogs & derivatives. J Med Chem 2010 Sep 9;53(17):6477-89
N-(2-(7-chloroquinolin-4-ylamino)ethyl)-N'-isopropyl-2-(4-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylmethyl)phenyl)acetamide  0   Chloroquine/*analogs & derivatives. J Med Chem 2008 Mar 13;51(5):1260-77
6-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexanoic acid (2-(7-chloroquinolin-4-ylamino)ethyl)-N-isopropylamide  0   Chloroquine/*analogs & derivatives. J Med Chem 2008 Mar 13;51(5):1260-77
N'-(7-chloroquinolin-4-yl)-N-(3-(10,11-dihydrodibenzo(b,f)azepin-5-yl)propyl)-N-methylpropane-1,3-diamine  0   *Dibenzazepines Chloroquine/*analogs & derivatives. J Med Chem 2006 Sep 7;49(18):5623-5
palladium-chloroquine  0   *Organometallic Compounds Chloroquine/*analogs & derivatives Palladium. J Inorg Biochem. 2006 Jan;100(1):152-7
4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine  0   *Pyrazoles Chloroquine/*analogs & derivatives. Bioorg Med Chem Lett. 2006 Feb1;16(3):649-53
ferrochloroquine  0   Chloroquine/*analogs & derivatives. Ann Trop Med Parasitol 2004 Jun;98(4):419-24
PfCRT protein, Plasmodium falciparum  0   *Protozoan Proteins *Membrane Transport Proteins Chloroquine. Mol Cell 2000 Oct;6(4):861-71
7-chloro-4-((2-(N,N-dimethylaminomethyl))-N-methylferrocenylamino)quinoline  0   *Ferric Compounds Chloroquine/*analogs & derivatives. Antimicrob Agents Chemother 1998 Mar;42(3):540-4
chloroquine(triphenylphosphine)gold(I)  0   *Organogold Compounds Chloroquine/*analogs & derivatives. J Med Chem 1997 Jun 6;40(12):1937-9
N-acetyldesethylchloroquine  0   Chloroquine/*analogs & derivatives. J Pharm Sci 1994 Jul;83(7):1040-2
Ro 11  0   *Chloroquine *Propylamines Drug Combinations. Ann Trop Med Parasitol 1992 Oct;86(5):467-73
ferriprotoporphyrin IX-chloroquine complex  0   *Hemin *Chloroquine. Biochim Biophys Acta 1991;1074(1):19
aminobenzoic acid, calcium pantothenate, chloroquine, quinacrine, pyridoxine drug combination  0   *Chloroquine *4-Aminobenzoic Acid *Pantothenic Acid *Pyridoxine *Quinacrine Drug Combinations. Presse Med 1986;15(39):1974
3-methylchloroquine  85-10-9   Chloroquine/*analogs & derivatives. Ann Trop Med Parasitol 1986;80(3):285
cloroquine, iodoquinol, tetracycline drug combination  0   *Chloroquine *Iodoquinol *Tetracycline Drug Combinations. Maroc Med 1980;2(4):427
N,N-dideethylchloroquine  4298-14-0   Chloroquine/*analogs & derivatives. Pharm Weekbl 1981;3 (6):263
chloroquine receptor  0   *Receptors, Drug Chloroquine. Antimicrob Agents Chemother 1981;19(4):589
fluoroquine  442-96-6   Chloroquine/*analogs & derivatives. Biopolymers 1981;20(3):435
chloroquine diphosphate  50-63-5 N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, phosphate (1:2)  Chloroquine/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Antimalarials ; Filaricides 		Fysiatr Reumatol Vestn 1980;58(1):23CHLOROQUINE PHOSPHATE; ARALEN; ARALEN PHOSPHATE W/ PRIMAQUINE PHOSPHATE
presocyl  78456-99-2 Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, mixt. with 2-(acetyloxy)benzoic acid and N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine  *Aspirin *Chloroquine *Prednisolone Drug Combinations. Pediatriia (11):70;1978; Vestn Dermatol Venerol 1:74;1978; Vestn Dermatol Venerol 2:54;1977
desethylchloroquine  1476-52-4   Chloroquine/*analogs & derivatives. Invest Ophthalmol 13(2):107;1974
chloroquine diorotate  16301-30-7   Chloroquine/*analogs & derivatives. Med Biol(Jap) 84(1):33;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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